Fish as Model Organism for the Identification of Marine Bioactive Compounds

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 4209

Special Issue Editor


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Guest Editor
Ctr Marine Sci CCMAR, Univ Algarve, 8005-139 Faro, Portugal
Interests: biomedicine; model organism; bone development; extracts from marine organisms; colorectal cancer; biomarker; vitamin
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Special Issue Information

Dear colleagues,                

Zebrafish (Danio rerio) and medaka (Oryzias latipes) are currently used as model organisms for the screening of molecules of interest for biomedical and pharmaceutical applications, and, in particular, for the identification of compounds capable of rescuing fish phenotypes mimicking human diseases. The marine environment, with its large diversity of habitats, hosts a plethora of species with a large diversity of physiological adaptations, which are the source of structurally unique natural products. In recent years, a number of molecules/extracts with specific biomedical applications have been isolated from marine organisms, and these proven to be effective in targeting prevalent and rare diseases or as sources to develop new analgesics, anti-inflammatory or antidiabetic drugs, to name only a few. The present Special Issue aims to bring together articles presenting a comprehensive overview of the use of fish as model organisms to identify marine derived compounds of biomedical interest.

Dr. M. Leonor Cancela
Guest Editor

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Keywords

  • marine drugs
  • in vitro experiment
  • drug discovery
  • bioactive compounds
  • marine organisms

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Published Papers (1 paper)

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Research

10 pages, 8778 KiB  
Article
Aerophobin-1 from the Marine Sponge Aplysina aerophoba Modulates Osteogenesis in Zebrafish Larvae
by Marta Carnovali, Maria Letizia Ciavatta, Ernesto Mollo, Vassilios Roussis, Giuseppe Banfi, Marianna Carbone and Massimo Mariotti
Mar. Drugs 2022, 20(2), 135; https://doi.org/10.3390/md20020135 - 11 Feb 2022
Cited by 5 | Viewed by 3072
Abstract
Longer life expectancy has led to an increase in efforts directed to the discovery of new healing agents for disorders related to aging, such as bone diseases. Harboring an incredible variety of bioactive metabolites, marine organisms are standing out as fruitful sources also [...] Read more.
Longer life expectancy has led to an increase in efforts directed to the discovery of new healing agents for disorders related to aging, such as bone diseases. Harboring an incredible variety of bioactive metabolites, marine organisms are standing out as fruitful sources also in this therapeutic field. On the other hand, the in vivo zebrafish model has proven to be an excellent low-cost screening platform for the fast identification of molecules able to regulate bone development. By using zebrafish larvae as a mineralization model, we have thus evaluated the effects of the crude acetonic extract from the marine sponge Aplysina aerophoba and its bromotyrosine components on bone development. Obtained results led to the selection of aerophobin-1 (1) as a promising candidate for applications in regenerative medicine, paving the way for the development of a novel therapeutic option in osteoporosis treatment. Full article
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