Fatty Acids from Marine Organisms, 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 17539

Special Issue Editors


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Guest Editor
National Research Council-Institute of Biomolecular Chemistry, 80078 Pozzuoli, NA, Italy
Interests: marine natural products; fatty acids; quorum sensing; biological activities
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
National Research Council-Institute of Biomolecular Chemistry, 80078 Pozzuoli, NA, Italy
Interests: marine natural products; antioxidants; fatty acids; enzymes; biotechnology; glycosylation; biotransformation; enzyme activity; polysaccharide; microorganisms; glycobiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of this Special Issue, “Fatty Acids from Marine Organisms, https://www.mdpi.com/journal/marinedrugs/special_issues/D0V374PLCE”, we are delighted to edit a second edition on this topical area.

The biological roles of marine lipids and, in particular, fatty acids are extensively described. They are compounds universally present in all organisms and play very important biological roles, such as being building blocks in biological membranes, concentrated sources of energy, and molecules involved in many physiological functions as well as signaling activities. In addition, in ecological investigations fatty acids and, in particular, some polyunsaturated fatty acids are considered to be very important biomolecules as trophic biomarkers in the marine food chain analyses of several ecological niches. Fatty acids from marine organisms are a precious source of molecules of high nutritional significance, like polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids.

For this second edition of our Special Issue, we invite academic and industry scientists to submit reviews and original research articles focusing on the chemistry, biological roles, and bioactivities of fatty acids from marine organisms.

Dr. Giuseppina Tommonaro
Dr. Annabella Tramice
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • marine microorganisms
  • marine invertebrates
  • fishes
  • biological properties
  • nutritional value
  • lipids
  • fatty acids

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Related Special Issue

Published Papers (8 papers)

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Research

Jump to: Review

21 pages, 2672 KiB  
Article
A Comparative Study of the Fatty Acid Profile of Non-Edible and Edible Tissues of Raw and Processed Common Octopus (Octopus vulgaris)
by Luis Freiría-Martínez, Marcos Trigo, Ricardo Prego and Santiago P. Aubourg
Mar. Drugs 2025, 23(5), 182; https://doi.org/10.3390/md23050182 - 24 Apr 2025
Viewed by 295
Abstract
A comparative study of the fatty acid (FA) composition of non-edible (viscera) and edible (mantle and arm) tissues of octopus (Octopus vulgaris) was carried out. According to the specimen size, three different groups (1–2 kg, 2–3 kg, and 3–4 kg, respectively) [...] Read more.
A comparative study of the fatty acid (FA) composition of non-edible (viscera) and edible (mantle and arm) tissues of octopus (Octopus vulgaris) was carried out. According to the specimen size, three different groups (1–2 kg, 2–3 kg, and 3–4 kg, respectively) were taken into account. The effect of the cooking process (40 min at 90 °C) and frozen storage (4 months at −18 °C) was analyzed. In all kinds of samples, the polyunsaturated FA (PUFA) group was the most abundant (p < 0.05) and monounsaturated FAs were the least abundant (p < 0.05). Lower (p < 0.05) ω3-PUFA, ω3/ω6 ratio and docosahexaenoic acid values were detected in viscera (35.4–41.9%, 3.0–4.5%, and 12.7–17.5%, respectively) than in edible tissues (44.4–52.5%, 4.1–6.1%, and 24.3–30.1%, respectively). Conversely, higher (p < 0.05) eicosapentaenoic acid content was detected in viscera (19.6–21.9%) than in the edible tissues (17.2–19.3%). In most cases, the cooking process and frozen storage led to an average decrease in the PUFA and ω3-PUFA content and to an increase in the saturated FA presence. In agreement with current nutritional recommendations, all tissues showed great levels of highly valuable indices regarding the lipid fraction. The study proves that viscera, a waste substrate, can be considered a relevant source for food and pharmaceutical industrial requirements. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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14 pages, 268 KiB  
Article
Polyunsaturated Fatty Acids Improved Long Term Prognosis by Reducing Oxidative Stress, Inflammation, and Endothelial Dysfunction in Acute Coronary Syndromes
by Alexandru Covaciu, Theodora Benedek, Elena Bobescu, Horatiu Rus, Valentina Benza, Luigi Geo Marceanu, Simona Grigorescu and Christian Gabriel Strempel
Mar. Drugs 2025, 23(4), 154; https://doi.org/10.3390/md23040154 - 1 Apr 2025
Viewed by 566
Abstract
Background: Oxidative stress, inflammation, and endothelial dysfunction are important processes in the progression of atherosclerosis and the occurrence of acute coronary syndromes (ACSs). Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are present in marine organisms and have the capacity to reduce all these processes [...] Read more.
Background: Oxidative stress, inflammation, and endothelial dysfunction are important processes in the progression of atherosclerosis and the occurrence of acute coronary syndromes (ACSs). Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are present in marine organisms and have the capacity to reduce all these processes and, at the same time, the progression of atherosclerosis and the emergence of ACSs. Aim: To evaluate the role of Omega-3 PUFAs therapy on parameters of oxidative stress, inflammatory syndrome, endothelial dysfunction, and long-term prognosis in acute coronary syndromes. Methods: One thousand one hundred forty patients were admitted to Clinic County Emergency Hospital Brasov with ACS and were enrolled in a prospective study. The study was divided into four groups related to the type of ACS and treatment with Omega-3 PUFAs added to the optimal medical therapy (OMT). The effect of Omega-3 PUFAs therapy associated with the OMT was determined by measuring the dynamics of the following parameters: (a) oxidative stress—total antioxidant status (TAS), oxidated low density lipoprotein cholesterol antibodies (Ab anti-ox-LDL), IgG anti-Myeloperoxidase antibodies (IgG type Ab anti-MPO); (b) inflammatory syndrome—C-reactive protein and fibrinogen; (c) endothelial dysfunction—flow mediated dilation (FMD) and von Willebrand factor (vWf) activity, from baseline to 6 months of follow-up. Clinical events followed at 5 years were cardiovascular and sudden death, Non-ST and ST segment elevation ACS, in stent thrombosis and restenosis, stroke, readmission in hospital for ACS and for heart failure. Results: In ACS groups, treatment with Omega-3 PUFAs added to the OMT significantly decreased the parameters of oxidative stress, inflammatory syndrome, and endothelial dysfunction at 6 months of follow-up. Regarding the clinical events, a significant reduction in the risk of cardiovascular and sudden death and a decreased incidence of Non-ST and ST segment elevation ACS, in-stent restenosis, readmission for ACS and heart failure, was observed in Omega-3 PUFA-treated groups in comparison to control groups. Conclusions: In acute coronary syndromes, therapy with Omega-3 PUFAs added to the OMT resulted in a significant decrease of parameters of oxidative stress, inflammation, and endothelial dysfunction at 6 months and also a significant improvement in the long-term prognosis. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
22 pages, 1491 KiB  
Article
Unveiling the Lipid Features and Valorization Potential of Atlantic Salmon (Salmo salar) Heads
by João Pedro Monteiro, Tiago Sousa, Tânia Melo, Carla Pires, António Marques, Maria Leonor Nunes, Ricardo Calado and M. Rosário Domingues
Mar. Drugs 2024, 22(11), 518; https://doi.org/10.3390/md22110518 - 15 Nov 2024
Cited by 2 | Viewed by 2252
Abstract
The sustainable utilization of co-products derived from the salmon processing industry is crucial for enhancing the viability and decreasing the environmental footprint of both capture and aquaculture operations. Salmon (Salmo salar) is one of the most consumed fish worldwide and a [...] Read more.
The sustainable utilization of co-products derived from the salmon processing industry is crucial for enhancing the viability and decreasing the environmental footprint of both capture and aquaculture operations. Salmon (Salmo salar) is one of the most consumed fish worldwide and a major species produced in aquaculture. As such, significant quantities of salmon co-products are produced in pre-commercialization processing/steaking procedures. The present study characterized a specific co-product derived from the processing of salmon: minced salmon heads. More specifically, this work aimed to reveal the nutritional profile of this co-product, with a special focus on its lipid content, including thoroughly profiling fatty acids and fully appraising the composition in complex lipids (polar lipids and triglycerides) for the first time. The antioxidant potential of lipid extracts from this salmon co-product was also studied in order to bioprospect lipid functional properties and possibly unveil new pathways for added-value applications. Our analysis indicated that these minced salmon heads are exceptionally rich in lipids. Oleic acid is the most prevalent fatty acid in this co-product, followed by palmitic acid, stearic acid, and linoleic acid. Moreover, relevant lipid indexes inferred from the fatty acid composition of this co-product revealed good nutritional traits. Lipidome analysis revealed that triglycerides were clearly the predominant lipid class present in this co-product while phospholipids, as well as ceramides, were also present, although in minimal quantities. The bioprospecting of antioxidant activity in the lipid extracts of the minced salmon heads revealed limited results. Given the high concentration of triglycerides, minced salmon heads can constitute a valuable resource for industrial applications from the production of fish oil to biodiesel (as triglycerides can be easily converted into fatty acid methyl esters), as well as possible ingredients for cosmetics, capitalizing on their alluring emollient properties. Overall, the valorization of minced salmon heads, major co-products derived from the processing of one of the most intensively farmed fish in the world, not only offers economic benefits but also contributes to the sustainability of the salmon processing industry by reducing waste and promoting a more efficient use of marine bioresources. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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19 pages, 9456 KiB  
Article
Reversed-Phase Medium-Pressure Liquid Chromatography Purification of Omega-3 Fatty Acid Ethyl Esters Using AQ-C18
by Mingxin Sang, Nan Pan, Jingna Wu, Xiaoting Chen, Shuilin Cai, Huan Fang, Meitian Xiao, Xiaoming Jiang and Zhiyu Liu
Mar. Drugs 2024, 22(6), 285; https://doi.org/10.3390/md22060285 - 19 Jun 2024
Viewed by 4658
Abstract
Omega-3 fatty acids are in high demand due to their efficacy in treating hypertriglyceridemia and preventing cardiovascular diseases. However, the growth of the industry is hampered by low purity and insufficient productivity. This study aims to develop an efficient RP-MPLC purification method for [...] Read more.
Omega-3 fatty acids are in high demand due to their efficacy in treating hypertriglyceridemia and preventing cardiovascular diseases. However, the growth of the industry is hampered by low purity and insufficient productivity. This study aims to develop an efficient RP-MPLC purification method for omega-3 fatty acid ethyl esters with high purity and capacity. The results indicate that the AQ-C18 featuring polar end-capped silanol groups outperformed C18 and others in retention time and impurity separation. By injecting pure fish oil esters with a volume equivalent to a 1.25% bed volume on an AQ-C18 MPLC column using a binary isocratic methanol–water (90:10, v:v) mobile phase at 30 mL/min, optimal omega-3 fatty acid ethyl esters were obtained, with the notable purity of 90.34% and a recovery rate of 74.30%. The total content of EPA and DHA produced increased from 67.91% to 85.27%, meeting the acceptance criteria of no less than 84% set by the 2020 edition of the Pharmacopoeia of the People’s Republic of China. In contrast, RP-MPLC significantly enhanced the production efficiency per unit output compared to RP-HPLC. This study demonstrates a pioneering approach to producing omega-3 fatty acid ethyl esters with high purity and of greater quantity using AQ-C18 RP-MPLC, showing this method’s significant potential for use in industrial-scale manufacturing. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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13 pages, 2079 KiB  
Article
Integrated Process for Schizochytrium Oil Extraction, Enzymatic Modification of Lipids and Concentration of DHA Fatty Acid Esters Using Alternative Methodologies
by Gonzalo Berzal, Paz García-García and Francisco Javier Señoráns
Mar. Drugs 2024, 22(4), 146; https://doi.org/10.3390/md22040146 - 26 Mar 2024
Cited by 4 | Viewed by 2901
Abstract
Marine microalgae Schizochytrium sp. have a high content of docosahexaenoic acid (DHA), an omega-3 fatty acid that is attracting interest since it prevents certain neurodegenerative diseases. The obtention of a bioactive and purified DHA fatty acid ester using a whole-integrated process in which [...] Read more.
Marine microalgae Schizochytrium sp. have a high content of docosahexaenoic acid (DHA), an omega-3 fatty acid that is attracting interest since it prevents certain neurodegenerative diseases. The obtention of a bioactive and purified DHA fatty acid ester using a whole-integrated process in which renewable sources and alternative methodologies are employed is the aim of this study. For this reason, lyophilized Schizochytrium biomass was used as an alternative to fish oil, and advanced extraction techniques as well as enzymatic modification were studied. Microalgal oil extraction was optimized via a surface-response method using pressurized liquid extraction (PLE) obtaining high oil yields (29.06 ± 0.12%) with a high concentration of DHA (51.15 ± 0.72%). Then, the enzymatic modification of Schizochytrium oil was developed by ethanolysis using immobilized Candida antarctica B lipase (Novozym® 435) at two reaction temperatures and different enzymatic loads. The best condition (40 °C and 200 mg of lipase) produced the highest yield of fatty acid ethyl ester (FAEE) (100%) after 8 h of a reaction attaining a cost-effective and alternative process. Finally, an enriched and purified fraction containing DHA-FAEE was obtained using open-column chromatography with a remarkably high concentration of 93.2 ± 1.3% DHA. The purified and bioactive molecules obtained in this study can be used as nutraceutical and active pharmaceutical intermediates of marine origin. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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13 pages, 1440 KiB  
Article
The Presence of Bioactive Compounds in European Eel (Anguilla anguilla) Skin: A Comparative Study with Edible Tissue
by Antía Bote, Marcos Trigo, Sidonia Martínez and Santiago P. Aubourg
Mar. Drugs 2024, 22(3), 105; https://doi.org/10.3390/md22030105 - 24 Feb 2024
Cited by 2 | Viewed by 2487
Abstract
The presence of bioactive compounds in European eel (Anguilla anguilla) skin was studied. Proximate and lipid class compositions and analysis of the fatty acid (FA) profile (individual FAs; FA groups, i.e., saturated, monounsaturated, and polyunsaturated; FA ratios, i.e., polyunsaturated/saturated, ω3/ω6) were [...] Read more.
The presence of bioactive compounds in European eel (Anguilla anguilla) skin was studied. Proximate and lipid class compositions and analysis of the fatty acid (FA) profile (individual FAs; FA groups, i.e., saturated, monounsaturated, and polyunsaturated; FA ratios, i.e., polyunsaturated/saturated, ω3/ω6) were determined and compared to the composition of the eel muscle. As a result, higher (p < 0.05) levels of proteins (271.6 g·kg−1), lipids (38.0 g·kg−1), ash (27.7 g·kg−1), and ω6 FAs were observed in the skin tissue. Contrary, the muscle tissue showed higher (p < 0.05) moisture, ω3 FA, and ω3/ω6 ratio values. Regarding lipid classes, a higher (p < 0.05) proportion of phospholipids (111.1 g·kg−1 lipids), free sterols (104.7 g·kg−1 lipids), α-tocopherol (274.0 mg·kg−1 lipids), and free FAs (43.6 g·kg−1 lipids) was observed in the skin tissue. No differences (p > 0.05) between both tissues could be detected for triacylglycerol and FA group (saturated, monounsaturated, and polyunsaturated) values and for the polyunsaturated/saturated FA ratio. It is concluded that European eel skin, a by-product resulting from commercial processing, can be considered a valuable source for the food and pharmaceutical industries by providing value-added constituents such as proteins, lipids, ω3 FAs, phospholipids, and α-tocopherol. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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Review

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21 pages, 717 KiB  
Review
Fatty Acids in Cnidaria: Distribution and Specific Functions
by Vasily I. Svetashev
Mar. Drugs 2025, 23(1), 37; https://doi.org/10.3390/md23010037 - 13 Jan 2025
Viewed by 1028
Abstract
The phylum Cnidaria comprises five main classes—Hydrozoa, Scyphozoa, Hexacorallia, Octocorallia and Cubozoa—that include such widely distributed and well-known animals as hard and soft corals, sea anemones, sea pens, gorgonians, hydroids, and jellyfish. Cnidarians play a very important role in marine ecosystems. The composition [...] Read more.
The phylum Cnidaria comprises five main classes—Hydrozoa, Scyphozoa, Hexacorallia, Octocorallia and Cubozoa—that include such widely distributed and well-known animals as hard and soft corals, sea anemones, sea pens, gorgonians, hydroids, and jellyfish. Cnidarians play a very important role in marine ecosystems. The composition of their fatty acids (FAs) depends on food (plankton and particulate organic matter), symbiotic photosynthetic dinoflagellates and bacteria, and de novo biosynthesis in host tissues. In cnidarian lipids, besides the common FA characteristics of marine organisms, numerous new and rare FAs are also found. All Octocorallia species and some Scyphozoa jellyfish contain polyunsaturated FAs (PUFAs) with 24 and 26 carbon atoms. The coral families can be distinguished by specific FA profiles: the presence of uncommon FAs or high/low levels of common fatty acids. Many of the families have characteristic FAs: Acroporidae are characterized by 18:3n6, eicosapentaenoic acid (EPA) 20:5n3, 22:4n6, and 22:5n3; Pocilloporidae by 20:3n6, 20:4n3, and docosahexaenoic acid 22:6n3 (DHA); and Poritidae by arachidonic acid (AA) and DHA. The species of Faviidae show elevated concentrations of 18:3n6 and 22:5n3 acids. Dendrophylliidae, being azooxanthellate corals, have such dominant acids as EPA and 22:5n3 and a low content of DHA, which is the major PUFA in hermatypic corals. The major and characteristic PUFAs for Milleporidae (class Hydrozoa) are DHA and 22:5n6, though in scleractinian corals, the latter acid is found only in trace amounts. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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15 pages, 1516 KiB  
Review
Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases
by Nova Yurika, Eleonora Montuori and Chiara Lauritano
Mar. Drugs 2024, 22(5), 229; https://doi.org/10.3390/md22050229 - 17 May 2024
Cited by 4 | Viewed by 2507
Abstract
Heart disease is one of the leading causes of death worldwide, and it is estimated that 17.9 million people die of it each year. The risk factors for cardiovascular diseases are attributable to an unhealthy and sedentary lifestyle, poor nutrition, stress, genetic predisposition, [...] Read more.
Heart disease is one of the leading causes of death worldwide, and it is estimated that 17.9 million people die of it each year. The risk factors for cardiovascular diseases are attributable to an unhealthy and sedentary lifestyle, poor nutrition, stress, genetic predisposition, diabetes, obesity, and aging. Marine microalgae have been the subject of numerous studies for their potential activity against several human diseases. They produce a plethora of primary and secondary metabolites such as essential nutrients, vitamins, pigments, and omega-3 fatty acid. Many of these molecules have antioxidant properties and have been shown to play a role in the prevention of heart diseases. The aim of this review is to summarize recent studies on the discovery of marine microalgal compounds and bioactivities for cardiovascular diseases, including in vitro and in vivo studies, showing and discussing recent discoveries and trends. The most promising results were found for microalgal polysaccharides, peptides and carotenoids. In conclusion, the overall data summarized here show that microalgae-based supplementation has the potential to improve age-related cardiovascular diseases and we expect more clinical studies in the future. Full article
(This article belongs to the Special Issue Fatty Acids from Marine Organisms, 2nd Edition)
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