Structure-Activity Relationships of Marine Natural Product
A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".
Deadline for manuscript submissions: 1 September 2026 | Viewed by 790
Editors
Interests: marine invertebrates; NMR; MS; chromatography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The importance of marine natural product biodiscovery in the identification of new therapeutic lead compounds remains high. Within the logical progression from initial discovery—whether through (meta)genomic profiling of biosynthetic gene clusters or bioassay-guided fractionation of a macro-organism—through biological profiling to full total synthesis, Structure–Activity Relationship (SAR) studies represent a critical step to understanding the molecular basis of the observed bioactivity. In addition, improving solubility, stability, distribution, and other pharmacokinetic properties relies upon a deep understanding of motifs within the lead compound that are critical to its efficacy, and others that tolerate modification. SAR, therefore, plays a vital role in the drug discovery process.
This Special Issue of Marine Drugs focuses on the importance SAR studies play in the potential development of natural products from marine environments, be it in structural studies of isolated or (semi)synthetic compounds, or bioactivity profiling of libraries of related compounds based upon marine-derived scaffolds. Submissions from academic and industrial laboratories are all welcome as we seek to better understand the importance of marine natural products as lead compounds in the fight against various disease states. We look forward to receiving your submissions in due course.
Dr. Rob Keyzers
Guest Editor
Dr. Helen Woolner
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- structural diversity
- synthesis
- semisynthesis
- bioactivity
- QSAR
- anticancer
- antibiotic
- anti-inflammatory
- antifungal
- library screening
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