marinedrugs-logo

Journal Browser

Journal Browser

Marine Natural Products with Anti-Aging Activity, 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 3044

Editors


E-Mail
Guest Editor
Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy
Interests: anti-aging; marine biotoxins; mussels; immune responses; storage lipids
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, Ancona, Italy
Interests: biology of aging; biogerontology; experimenetal gerontology; geroscience; cellular senescence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Building on the success of our first edition (https://www.mdpi.com/journal/marinedrugs/special_issues/87OS9N2S7J), this Special Issue will showcase advances in discovering, characterizing and translating marine-derived molecules and bioproducts that modulate fundamental mechanisms of aging and age-related pathologies.

We welcome original research, reviews, short communications, methods and perspective articles that focus on the following:

  • Elucidate anti-aging mechanisms of marine natural products mapped to established hallmarks (e.g., oxidative stress, mitochondrial dysfunction, loss of proteostasis/autophagy, cellular senescence and inflammaging, and ECM remodeling/skin photoaging).
  • Integrate multi-omics, chemoinformatics/AI, network pharmacology or synthetic biology to accelerate discovery and sustainable production from marine macro- and micro-organisms.
  • Evaluate efficacy across models (cells, invertebrates, fish, rodents, and humans) with standardized readouts of healthspan/lifespan and clinically relevant biomarkers.
  • Advance formulation, delivery, pharmacokinetics and safety, bridging laboratory findings to pharmaceutical, nutraceutical and dermocosmetic applications.
  • Draw mechanistic insights from long-lived marine species to inspire intervention design.

We particularly encourage submissions that connect a defined marine product to a specific aging determinant, and translational studies addressing age-related diseases.

Dr. Maria Elisa Giuliani
Dr. Marco Malavolta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • neuroinflammation
  • hallmarks of aging
  • cellular senescence
  • senolytics
  • senomorphics
  • mitophagy
  • autophagy
  • proteostasis
  • inflammaging
  • NAD+ metabolism
  • extracellular matrix
  • photoaging
  • skin aging
  • healthspan
  • lifespan
  • marine peptides
  • phlorotannins
  • fucoidans
  • carotenoids
  • marine polysaccharides
  • marine microbes/microalgae
  • sustainable bioproduction
  • synthetic biology
  • dereplication
  • network pharmacology
  • chemoinformatics
  • multi-omics
  • drug delivery
  • pharmacokinetics
  • toxicity
  • clinical translation
  • nutraceuticals
  • cosmeceuticals

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

33 pages, 3197 KB  
Article
Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract
by Fabien Havas, Shlomo Krispin, Moshe Cohen and Joan Attia-Vigneau
Mar. Drugs 2026, 24(3), 99; https://doi.org/10.3390/md24030099 - 1 Mar 2026
Viewed by 2567
Abstract
Red microalga Porphyridium cruentum produces a sulfated exopolysaccharide (EPS), which enables its survival in challenging intertidal and spray zones. Extracellular polysaccharide hyaluronic acid (HA) plays important roles in skin hydration, elasticity, and volume. However, with aging, HA decreases and loses effectiveness, reducing skin [...] Read more.
Red microalga Porphyridium cruentum produces a sulfated exopolysaccharide (EPS), which enables its survival in challenging intertidal and spray zones. Extracellular polysaccharide hyaluronic acid (HA) plays important roles in skin hydration, elasticity, and volume. However, with aging, HA decreases and loses effectiveness, reducing skin moisture retention and firmness, and increasing signs of aging. An effective topical alternative to injectable HA replacement remains a largely unmet need. An extract of Porphyridium cultivated in natural sunlight, rich in EPS and polydeoxyribonucleotides (PDRNs), significantly activated the ADORA2A receptor in a CHO model, as well as reduced inflammation and increased collagen and HA production, autophagic flux, and key autophagy gene expression in dermal fibroblast cultures. In a double-blind clinical trial with placebo and HA benchmark controls, the Porphyridium extract delivered significant HA-like skin plumpness, hydration, and radiance benefits, and reduced signs of aging. The extract generally equaled or exceeded the HA benchmark. Its meaningful, swift HA-like activity shows potential for a safe, natural, and arguably more powerful HA-like alternative. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-Aging Activity, 2nd Edition)
Show Figures

Figure 1

Back to TopTop