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Marine Drugs
Special Issues
Marine Natural Products with Anti-Inflammatory Effects
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Marine Natural Products with Anti-Inflammatory Effects

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5410

Special Issue Editor

Dr. Ekaterina S. Menchinskaya

E-Mail Website
Guest Editor
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia
Interests: biochemistry; cell biology; mechanism of the biological activity of natural and synthetic biologically active substances; inflammation; new drug discovery; molecular targets; oncology; apoptosis; neurodegenerative disorders; cytoprotection; cells of the immune system
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation is the first reaction of the body's immune system to damage or injury, microbial invasion and immune responses. Acute inflammation is a protective reaction that usually subsides after a few days. However, in some diseases, the immune system mistakenly fights against the body's own cells, causing chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel diseases, COPD, etc. These diseases can last for years or even a lifetime. Natural compounds of organisms of marine origin are known for their structural diversity and wide range of biological activities. Thus, they are a highly promising chemical resource for the discovery of active compounds that may serve as potential anti-inflammatory drugs.

This Special Issue aims to present research articles on the anti-inflammatory properties of marine natural compounds. We particularly welcome works on the isolation and determination of the structure of new compounds of marine origin that have anti-inflammatory activities and are based on the latest in vitro and in vivo models

Dr. Ekaterina S. Menchinskaya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new drug discovery and development
  • inflammation
  • anti-inflammatory agents
  • biologically active marine compounds
  • reactive oxygen species (ROS)
  • immune system
  • non-steroidal anti-inflammatory drugs (NSAIDs)
  • immunomodulation
  • cytokines

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Published Papers (3 papers)

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Research

17 pages, 1623 KiB  
Article
Pepsin Hydrolysate from Surimi Industry-Related Olive Flounder Head Byproducts Attenuates LPS-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages and In Vivo Zebrafish Model
by H. H. A. C. K. Jayawardhana, N. M. Liyanage, D. P. Nagahawatta, Hyo-Geun Lee, You-Jin Jeon and Sang In Kang
Mar. Drugs 2024, 22(1), 24; https://doi.org/10.3390/md22010024 - 28 Dec 2023
Cited by 1 | Viewed by 1857
Abstract
Fish head byproducts derived from surimi processing contribute about 15% of the total body weight, which are beneficial to health because they contain essential nutrients. In this study, olive flounder (OF) was the target species in order to maximize the byproduct utilization. In [...] Read more.
Fish head byproducts derived from surimi processing contribute about 15% of the total body weight, which are beneficial to health because they contain essential nutrients. In this study, olive flounder (OF) was the target species in order to maximize the byproduct utilization. In RAW 264.7 macrophages, the seven hydrolysates from OF head byproducts were examined for their inhibitory potential against inflammation and the oxidative stress induced by lipopolysaccharides (LPS). The pepsin hydrolysate (OFH–PH) demonstrated strong anti-inflammatory activity via the down-regulation of NO production, with an IC50 value of 299.82 ± 4.18 µg/mL. We evaluated the inhibitory potential of pro-inflammatory cytokines and PGE2 to confirm these findings. Additionally, iNOS and COX-2 protein expressions were confirmed using western blotting. Furthermore, the results from the in vivo zebrafish model demonstrated that OFH–PH decreased the LPS-elevated heart rate, NO production, cell death, and intracellular ROS level, while increasing the survival percentage. Hence, the obtained results of this study serve as a platform for future research and provide insight into the mediation of inflammatory disorders. These results suggest that OFH–PH has the potential to be utilized as a nutraceutical and functional food ingredient. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-Inflammatory Effects)
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12 pages, 2803 KiB  
Article
Streptinone, a New Indanone Derivative from a Marine-Derived Streptomyces massiliensis, Inhibits Particulate Matter-Induced Inflammation
by Hwa-Sun Lee, Dineth Pramuditha Nagahawatta, You-Jin Jeon, Min Ah Lee, Chang-Su Heo, Sun Joo Park and Hee Jae Shin
Mar. Drugs 2023, 21(12), 640; https://doi.org/10.3390/md21120640 - 14 Dec 2023
Viewed by 1815
Abstract
Inflammatory diseases caused by air pollution, especially from particulate matter (PM) exposure, have increased daily. Accordingly, attention to treatment or prevention for these inflammatory diseases has grown. Natural products have been recognized as promising sources of cures and prevention for not only inflammatory [...] Read more.
Inflammatory diseases caused by air pollution, especially from particulate matter (PM) exposure, have increased daily. Accordingly, attention to treatment or prevention for these inflammatory diseases has grown. Natural products have been recognized as promising sources of cures and prevention for not only inflammatory but also diverse illnesses. As part of our ongoing study to discover bioactive compounds from marine microorganisms, we isolated streptinone, a new indanone derivative (1), along with three known diketopiperazines (2–4) and piericidin A (5), from a marine sediment-derived Streptomyces massiliensis by chromatographic methods. The structure of 1 was elucidated based on the spectroscopic data analysis. The relative and absolute configurations of 1 were determined by 1H-1H coupling constants, 1D NOESY, and ECD calculation. The anti-inflammatory activities of 1 were evaluated through enzyme-linked immunosorbent assay (ELISA), Western blot, and qPCR. Compound 1 suppressed the production of nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, by inhibiting the Toll-like receptor (TLR)-mediated nuclear factor kappa B (NF-κB) signaling pathway. Therefore, compound 1 could potentially be used as an agent in the prevention and treatment of diverse inflammatory disorders caused by particulate matter. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-Inflammatory Effects)
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26 pages, 16732 KiB  
Article
New Insight on the Cytoprotective/Antioxidant Pathway Keap1/Nrf2/HO-1 Modulation by Ulva intestinalis Extract and Its Selenium Nanoparticles in Rats with Carrageenan-Induced Paw Edema
by May Almukainzi, Thanaa A. El-Masry, Hend Selim, Asmaa Saleh, Mostafa El-Sheekh, Mofida E. M. Makhlof and Maisra M. El-Bouseary
Mar. Drugs 2023, 21(9), 459; https://doi.org/10.3390/md21090459 - 22 Aug 2023
Cited by 2 | Viewed by 1291
Abstract
Currently, there is growing interest in exploring natural bioactive compounds with anti-inflammatory potential to overcome the side effects associated with the well-known synthetic chemicals. Algae are a rich source of bioactive molecules with numerous applications in medicine. Herein, the anti-inflammatory effect of Ulva [...] Read more.
Currently, there is growing interest in exploring natural bioactive compounds with anti-inflammatory potential to overcome the side effects associated with the well-known synthetic chemicals. Algae are a rich source of bioactive molecules with numerous applications in medicine. Herein, the anti-inflammatory effect of Ulva intestinalis alone or selenium nanoparticles loaded with U. intestinalis (UISeNPs), after being fully characterized analytically, was investigated by a carrageenan-induced inflammation model. The pretreated groups with free U. intestinalis extract (III and IV) and the rats pretreated with UISeNPs (groups V and VI) showed significant increases in the gene expression of Keap1, with fold increases of 1.9, 2.27, 2.4, and 3.32, respectively. Similarly, a remarkable increase in the Nrf2 gene expression, with 2.09-, 2.36-, 2.59-, and 3.7-fold increases, was shown in the same groups, respectively. Additionally, the groups III, IV, V, and VI revealed a significantly increased HO-1 gene expression with a fold increase of 1.48, 1.61, 1.87, and 2.84, respectively. Thus, both U. intestinalis extract and the UISeNPs boost the expression of the cytoprotective/antioxidant pathway Keap1/Nrf2/HO-1, with the UISeNPs having the upper hand over the free extract. In conclusion, U. intestinalis and UISeNPs have proven promising anti-inflammatory activity through mediating different underlying mechanisms. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-Inflammatory Effects)
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