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Marine Drugs
Special Issues
Exploring of Microalgae for Biotechnology Applications
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Exploring of Microalgae for Biotechnology Applications

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 12169

Special Issue Editor

Dr. Xuemei Mao

E-Mail Website
Guest Editor
Department of Civil Engineering, The University of Hong Kong, Hong Kong, China
Interests: microalgal biotechnology; metabolic engineering; natural products; metagenomics

Special Issue Information

Dear Colleagues,

Microalgae are widely used in various biotechnological industries including food, nutraceutical, biomedical, agriculture, and environmental processes. To promote the application of microalgae in these areas, better knowledge of their characteristics, and technological advancements in cultivation and downstream processing, are needed. Furthermore, new possibilities for biotechnological applications should be explored. This Special Issue is seeking high-quality research articles and reviews to discuss recent achievements in the biotechnology applications of microalgae for bioactive compound and bio-product production, or their other potentials in pharmaceutical, nutraceutical, or biomedical industries. As the Guest Editor, it's my pleasure to invite researchers in this field to contribute their latest research advances to this Special Issue.

Dr. Xuemei Mao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microalgae
  • biotechnology
  • bioactive natural products
  • microalgal cultivation
  • nutraceutical
  • biomedical
  • industrial application

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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12 pages, 2153 KiB  
Article
Alkaline Phosphatase PhoD Mutation Induces Fatty Acid and Long-Chain Polyunsaturated Fatty Acid (LC-PUFA)-Bound Phospholipid Production in the Model Diatom Phaeodactylum tricornutum
by Kaidian Zhang, Jiashun Li, Jie Cheng and Senjie Lin
Mar. Drugs 2023, 21(11), 560; https://doi.org/10.3390/md21110560 - 26 Oct 2023
Cited by 2 | Viewed by 2438
Abstract
With rapid growth and high lipid contents, microalgae have become promising environmentally friendly candidates for renewable biodiesel and health supplements in our era of global warming and energy depletion. Various pathways have been explored to enhance algal lipid production, especially gene editing. Previously, [...] Read more.
With rapid growth and high lipid contents, microalgae have become promising environmentally friendly candidates for renewable biodiesel and health supplements in our era of global warming and energy depletion. Various pathways have been explored to enhance algal lipid production, especially gene editing. Previously, we found that the functional loss of PhoD-type alkaline phosphatase (AP), a phosphorus-stress indicator in phytoplankton, could lead to increased lipid contents in the model diatom Phaeodactylum tricornutum, but how the AP mutation may change lipid composition remains unexplored. This study addresses the gap in the research and investigates the effects of PhoD-type AP mutation on the lipid composition and metabolic regulation in P. tricornutum using transcriptomic and lipidomic analyses. We observed significantly modified lipid composition and elevated production of fatty acids, lysophosphatidylcholine, lysophosphatidylethanolamine, ceramide, phosphatidylinositol bisphosphate, and monogalactosylmonoacylglycerol after PhoD_45757 mutation. Meanwhile, genes involved in fatty acid biosynthesis were upregulated in mutant cells. Moreover, the mutant exhibited increased contents of ω-3 long-chain polyunsaturated fatty acid (LC-PUFA)-bound phospholipids, indicating that PhoD_45757 mutation could improve the potential bioavailability of PUFAs. Our findings indicate that AP mutation could influence cellular lipid synthesis and probably redirect carbon toward lipid production and further demonstrate that AP mutation is a promising approach for the development of high-value microalgal strains for biomedical and other applications. Full article
(This article belongs to the Special Issue Exploring of Microalgae for Biotechnology Applications)
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Review

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19 pages, 1281 KiB  
Review
Nannochloropsis as an Emerging Algal Chassis for Light-Driven Synthesis of Lipids and High-Value Products
by Ying Ye, Meijing Liu, Lihua Yu, Han Sun and Jin Liu
Mar. Drugs 2024, 22(2), 54; https://doi.org/10.3390/md22020054 - 24 Jan 2024
Cited by 19 | Viewed by 5924
Abstract
In light of the escalating global energy crisis, microalgae have emerged as highly promising producers of biofuel and high-value products. Among these microalgae, Nannochloropsis has received significant attention due to its capacity to generate not only triacylglycerol (TAG) but also eicosapentaenoic acid (EPA) [...] Read more.
In light of the escalating global energy crisis, microalgae have emerged as highly promising producers of biofuel and high-value products. Among these microalgae, Nannochloropsis has received significant attention due to its capacity to generate not only triacylglycerol (TAG) but also eicosapentaenoic acid (EPA) and valuable carotenoids. Recent advancements in genetic tools and the field of synthetic biology have revolutionized Nannochloropsis into a powerful biofactory. This comprehensive review provides an initial overview of the current state of cultivation and utilization of the Nannochloropsis genus. Subsequently, our review examines the metabolic pathways governing lipids and carotenoids, emphasizing strategies to enhance oil production and optimize carbon flux redirection toward target products. Additionally, we summarize the utilization of advanced genetic manipulation techniques in Nannochloropsis. Together, the insights presented in this review highlight the immense potential of Nannochloropsis as a valuable model for biofuels and synthetic biology. By effectively integrating genetic tools and metabolic engineering, the realization of this potential becomes increasingly feasible. Full article
(This article belongs to the Special Issue Exploring of Microalgae for Biotechnology Applications)
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22 pages, 2138 KiB  
Review
Research Progress in Heterologous Crocin Production
by Junjie Zhou, Danqiong Huang, Chenglong Liu, Zhangli Hu, Hui Li and Sulin Lou
Mar. Drugs 2024, 22(1), 22; https://doi.org/10.3390/md22010022 - 28 Dec 2023
Cited by 3 | Viewed by 3357
Abstract
Crocin is one of the most valuable components of the Chinese medicinal plant Crocus sativus and is widely used in the food, cosmetics, and pharmaceutical industries. Traditional planting of C. sativus is unable to fulfill the increasing demand for crocin in the global [...] Read more.
Crocin is one of the most valuable components of the Chinese medicinal plant Crocus sativus and is widely used in the food, cosmetics, and pharmaceutical industries. Traditional planting of C. sativus is unable to fulfill the increasing demand for crocin in the global market, however, such that researchers have turned their attention to the heterologous production of crocin in a variety of hosts. At present, there are reports of successful heterologous production of crocin in Escherichia coli, Saccharomyces cerevisiae, microalgae, and plants that do not naturally produce crocin. Of these, the microalga Dunaliella salina, which produces high levels of β-carotene, the substrate for crocin biosynthesis, is worthy of attention. This article describes the biosynthesis of crocin, compares the features of each heterologous host, and clarifies the requirements for efficient production of crocin in microalgae. Full article
(This article belongs to the Special Issue Exploring of Microalgae for Biotechnology Applications)
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