Molecular Links Between Mitochondrial Dynamics and Neurodegenerative Diseases

Dear Colleagues,

Mitochondria play an important role in many cellular activities and are highly dynamic organelles that constantly undergo fusion and fission. Mitochondrial morphology results from the delicate balance of the processes of fission and fusion. A large number of studies reported that an imbalance of mitochondrial dynamics plays a critical role in various major neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). In addition, fragmented mitochondrial morphology has been observed in patients with sporadic Amyotrophic lateral sclerosis (ALS) and other ALS experimental models.

Mitochondrial dysfunction and abnormal mitochondrial dynamics in neurons is one of the key pathogenic mechanisms in several neurodegenerative diseases. Furthermore, various evidences suggest that the imbalanced mitochondrial dynamics in neurons are linked to human neurodegenerative diseases. However, the effects and molecular mechanisms of imbalanced mitochondrial dynamics on pathogenesis of neurodegenerative disease have not yet been fully established, and due to multifaceted roles of mitochondria in neurons, many unsolved questions remain in this research field.

This Special Issue focuses on the pathological role of mitochondrial dynamics in neurodegenerative disorders including AD, PD, HD, and ALS. Moreover, contributions to this Special Issue may cover all research aspects related to the mitochondrial redox biology, mitochondrial activity, as well as molecular mechanisms of mitochondrial biogenesis in neurodegenerative diseases. Original articles, reviews, protocols and opinions covering the below key words are considered.

Dr. Kiyoung Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Mitochondrial dynamics
• Mitochondrial metabolism
• Organelle interaction with mitochondria
• Mitochondrial redox signaling
• Neurodegenerative diseases