Explore Innovative Exercise-Based Interventions for Chronic Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 1680
Special Issue Editor
Interests: environmental exercise physiology; physiological responses to acute exercise; exercise training; exercise metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress (OS) results from an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defense capacity. OS contributes to cellular and DNA damage and plays a key role in the pathogenesis of various diseases, including cancer, metabolic syndrome, cardiovascular disease (CVD), and neurodegenerative disorders. Likewise, inflammation—while essential for immune defense—can have harmful effects when chronically elevated, as seen in many lifestyle-related and chronic diseases. Obesity is a well-known example, characterized by persistent low-grade inflammation.
Emerging evidence suggests that regular physical activity and structured exercise training can help restore redox balance and attenuate systemic inflammation by enhancing antioxidant defense and modulating immune function. In contrast, acute bouts of intense exercise may temporarily increase OS, leading to muscle damage, inflammation, and atrophy. Interestingly, exercise-induced OS also appears to support muscle regeneration following injury, reflecting the dual and context-dependent nature of exercise responses. However, the mechanisms behind these paradoxical effects are not yet completely understood.
Following the positive reception of the previous edition, we are pleased to continue this scientific dialog by inviting contributions that explore the complex interactions between physical activity, oxidative stress, and inflammation. We welcome submissions based on human and animal models, as well as studies examining how environmental stressors—such as particulate matter exposure or hypoxic conditions—interact with exercise-related physiological responses.
Through this Special Issue, we hope to foster deeper insight into the therapeutic potential of exercise in managing OS- and inflammation-related conditions, and to encourage the continued exploration of the complex underlying biological mechanisms.
Dr. Hee-Tae Roh
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- physical activity
- acute exercise
- exercise training
- inflammation
- oxidative stress
- antioxidant
- chronic disease
- environmental stress
- brain health
- aging
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