Metabolic Biochemistry During Exercise: Contemporary Understandings and New Approaches to Improved Models, Methodologies and Data Interpretations
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 206
Special Issue Editor
Interests: systems physiology during exercise; muscle metabolism, biochemistry of metabolic acidosis; indirect calorimetry during exercise; VO2 kinetics to steady state in addition to incremental and non-steady state exercise
Special Issue Information
Dear Colleagues,
This Special Issue is centered around the need to challenge convention in the understanding of the biochemistry of the energetics of skeletal muscle contraction during exercise, in addition to the systemic acidosis responses to numerous disease processes. The underlying model of most prior studies of muscle metabolism has been based on whole-body (wb) gas exchange, limb gas exchange, and whole muscle samples (human muscle biopsy, human magnetic resonance imaging and spectroscopy, animal limb models and biopsy, etc.), with limited recognition of the limitations imposed by these methods due to the All Or None Law of muscle contraction combined with the Size Principle of motor unit recruitment.
Core topics that challenge the conventions of important wb oxygen consumption (wb-VO2) measures (maximal VO2 (VO2max); VO2 gain; VO2 kinetics; and the economy and efficiency of muscle contractions during exercise), the biochemistry of skeletal muscle metabolic acidosis, and skeletal-muscle-fiber-type-specific biochemistry of energy metabolism will be presented with the overarching purpose of (1) stimulating the further understanding, interest, and research into these topics, and (2) improving the understanding of how the realities of the All Or None Law of muscle contraction combined with the Size Principle of motor unit recruitment influence skeletal muscle metabolism.
Dr. Robert Andrew Robergs
Guest Editor
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Keywords
- skeletal muscle
- energy catabolism
- oxygen consumption (VO2)
- acidosis
- VO2 kinetics
- efficiency
- economy
- glycolysis
- lactate
- glycogen
- fatigue
- disease
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