Cardiovascular Control Mechanisms: From Physiology to the Bedside
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 181
Special Issue Editors
Interests: heart failure; atrial fibrillation; cardiovascular medicine; myocardial infarction
Interests: hypertension; blood pressure; heart failure; cardiac function; atrial fibrillation; echocardiography; cardio-vascular medicine; myocardial infarction; atherosclerosis ; clinical cardiology
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Special Issue Information
Dear Colleagues,
Systems that control cardiovascular activity are involved in both the onset and the progression of cardiovascular diseases. It is therefore more and more evident how important it is to study the different mechanisms that modulate cardiovascular activity, such as the neural regulatory system and the mechanisms activating the inflammatory cascade or the immune response.
In this regard, recent advances in neuroscience, molecular biology, monitoring technologies, and neuromodulatory therapies are focusing contemporary research on particularly promising areas. These include the study of the dynamic interaction between different systems like the autonomic nervous system, respiratory and thermoregulatory systems, the immune system or inflammation, in order to understand how cardiovascular control derangements due to autonomic dysfunction influence the progression of cardiovascular diseases, such as heart failure, hypertension, and arrhythmias. These studies could lead to new therapies and identify more sensitive biomarkers, for instance, indices of cardiovascular variability and cardiorespiratory coupling, electrophysiological markers, and levels of neuropeptides and inflammatory cytokines. Technological developments in smart wearables and biosensors enable long-term, uninterrupted monitoring, without interfering with daytime activities or nighttime sleep; assisted with artificial intelligence algorithms, they might allow the early identification of an altered cardiovascular control. The rapid development of neuromodulatory techniques, such as vagus nerve or spinal cord stimulation, renal denervation, and baroreflex activation, may allow to directly intervene on neural circuits and restore the functionality of the cardiovascular regulation, especially in patients refractory to conventional therapies. These approaches represent an emerging frontier towards increasingly personalized interventions aimed at restoring the mechanisms of cardiovascular regulation.
Therefore, a better knowledge of the interaction of the different systems and their molecular background is mandatory to improve the diagnostic power and therapeutic tools in this area, which still presents a high burden of disability and mortality.
On these premises, we are launching the present Special Issue, aimed at collecting contributions that may improve our knowledge of the mechanisms of cardiovascular regulation in physiological studies or clinical settings. Manuscripts reviewing the state of the art of these topics are also welcome.
Dr. Alberto Radaelli
Dr. Paolo Castiglioni
Guest Editors
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Keywords
- heart failure
- coronary disease
- autonomic control
- intrinsic cardiac nervous system
- heart rate variability
- Holter
- sleep study
- vagal nerve stimulation
- inflammatory markers
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