Prosthetic Joint Infections: A Multidisciplinary Approach

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 1884

Special Issue Editor


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Guest Editor
Orthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
Interests: orthopaedic oncology; bone and joint infections; hip replacement; knee replacement; bone tumours; soft tissue sarcomas
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Special Issue Information

Dear Colleagues,

The treatment of prosthetic infections represents a significant challenge for patients, healthcare providers and the healthcare system due to the high rate of treatment failure and the high economic impact of managing these diseases. Continuous collaboration between orthopedists and infectivologists could optimize the management of all musculoskeletal infections. However, for some very complex pathological scenarios, further multidisciplinary integration is desirable in both clinical and pre-clinical settings. Therefore, various specialists—particularly plastic surgeons, vascular surgeons and general surgeons—are asked to contribute to the clinical assessment and determine the treatment, which is often personalized. Meanwhile, microbiologists, clinical pharmacologists and pathologists can aid in clinical decision-making and contribute to the introduction of novel methods and techniques.

This Special Issue, entitled “Prosthetic Joint Infections: A Multidisciplinary Approach”, aims to collect data related to clinical and pre-clinical activities arising from the management of patients with periprosthetic or hardware-related infections. It will particularly focus on the application of multidisciplinary teamwork in the management of these patients.

We are pleased to invite you to contribute to this Special Issue, as we strongly believe that the dissemination of knowledge can enhance the management of such complex matters. In this Special Issue, original research articles and reviews are welcome. The scope of this Special Issue includes, but is not limited to, the following topics:

  • Orthoplastic approaches;
  • Prosthetic joint infection;
  • Diagnosis and management of PJI;
  • Antibiotic therapy in periprosthetic infections.

We look forward to receiving your contributions.

Dr. Andrea Sambri
Guest Editor

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Keywords

  • orthoplastic approach
  • prosthetic joint infection
  • diagnosis and management of PJI
  • antibiotic therapy in periprosthetic infections

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Published Papers (2 papers)

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Review

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20 pages, 423 KB  
Review
Infection in Joint Arthroplasty: Diagnosis, Prevention, and Treatment Strategies—A Comprehensive Narrative Review
by Jovana Grupkovic, Miroslav Ceculovic, Uros Dabetic, Dejan Aleksandric, Nikola Bogosavljevic, Ranko Lazovic and Slavisa Zagorac
Life 2025, 15(12), 1853; https://doi.org/10.3390/life15121853 - 2 Dec 2025
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Abstract
Background: Periprosthetic joint infection (PJI) remains one of the most severe complications after total joint arthroplasty, causing significant morbidity and healthcare burden. Despite advances in surgical techniques, diagnostics, and antimicrobial therapy, infection rates have not declined substantially, emphasizing the need for comprehensive preventive [...] Read more.
Background: Periprosthetic joint infection (PJI) remains one of the most severe complications after total joint arthroplasty, causing significant morbidity and healthcare burden. Despite advances in surgical techniques, diagnostics, and antimicrobial therapy, infection rates have not declined substantially, emphasizing the need for comprehensive preventive and therapeutic strategies. Methods: This narrative review synthesizes evidence from peer-reviewed clinical studies, consensus statements, and major international guidelines addressing periprosthetic joint infection in hip, knee, and shoulder arthroplasty. Results: Recent evidence highlights advances in diagnostic biomarkers, molecular testing, and standardized consensus criteria that have improved early detection. Surgical strategies such as DAIR, one-stage, and two-stage revisions—combined with biofilm-active antimicrobial therapy—remain the mainstay of management. Preventive measures focusing on perioperative optimization, infection control, and antibiotic stewardship are the most effective means to reduce infection risk. Conclusions: Future progress relies on precision-based prevention, novel biofilm-targeted therapies, and multidisciplinary collaboration to achieve durable, infection-free outcomes following joint arthroplasty. Full article
(This article belongs to the Special Issue Prosthetic Joint Infections: A Multidisciplinary Approach)
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Other

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10 pages, 10007 KB  
Case Report
Periprosthetic Joint Infection by Streptococcus bovis Reveals Hidden Colorectal Cancer: A Case Report
by George Viscopoleanu, Mihai-Sebastian Valeanu, Bogdan-Sorin Capitanu, Serban Dragosloveanu and Cristian Scheau
Life 2025, 15(9), 1385; https://doi.org/10.3390/life15091385 - 1 Sep 2025
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Abstract
Periprosthetic joint infection (PJI) caused by Streptococcus bovis (S. bovis) is rare but clinically significant due to its established association with colorectal neoplasia. Early recognition and interdisciplinary management are essential to ensure favorable outcomes. We report the case of a 68-year-old [...] Read more.
Periprosthetic joint infection (PJI) caused by Streptococcus bovis (S. bovis) is rare but clinically significant due to its established association with colorectal neoplasia. Early recognition and interdisciplinary management are essential to ensure favorable outcomes. We report the case of a 68-year-old woman who presented with a chronic fistula and signs of active infection 20 years after uncemented total hip arthroplasty. Cultures from the wound identified S. bovis, prompting further evaluation. Imaging and laboratory tests supported a diagnosis of chronic PJI. A two-stage revision was performed, beginning with implant removal, debridement, and placement of a vancomycin/gentamicin-loaded spacer. Given the pathogen’s known link to gastrointestinal malignancy, the patient underwent colonoscopy, which revealed a tubulovillous adenoma with carcinoma in situ. Surgical resection was performed with curative intent. Six months later, the patient underwent successful reimplantation. At three-month follow-up, clinical and radiographic assessments showed favorable recovery. This case reinforces the importance of gastrointestinal screening in patients with S. bovis PJI, as early detection of associated colorectal lesions may impact treatment strategies and prognosis. Full article
(This article belongs to the Special Issue Prosthetic Joint Infections: A Multidisciplinary Approach)
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