Personalized Management of Heart Failure: From Biomarkers to Clinical Practice

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 25 August 2026 | Viewed by 364

Special Issue Editor


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Guest Editor
Postgraduate Program in Medicine and Health, Universidade Federal da Bahia (UFBA), Salvador 40170-110, Brazil
Interests: heart failure; arterial hypertension; intensive care; critical care

Special Issue Information

Dear Colleagues,

Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, representing one of the most pressing challenges in cardiovascular medicine. Despite significant advances in pharmacological and device-based therapies, the global burden of HF continues to rise, fueled by population aging, multimorbidity, and widening disparities in healthcare delivery. This Special Issue aims to address the rapidly evolving landscape of HF research and clinical practice, providing a platform for the generation of novel insights, critical discussions, and future perspectives.

This Special Issue aims to cover a wide range of contemporary topics in heart failure, including, but not limited to, the following:

  • Advances in guideline-directed medical therapy (GDMT), including SGLT2 inhibitors, ARNIs, MRAs, and novel potassium binders.
  • Precision medicine approaches and the role of genetics, biomarkers, and imaging in risk stratification.
  • New perspectives on HF phenotypes, particularly HFpEF, HFmrEF, and their overlap with metabolic and renal syndromes.
  • Digital health and artificial intelligence applications for remote monitoring, prognosis, and treatment optimization.
  • Device therapy and interventional strategies, such as LV assist devices, percutaneous valve interventions, and remote hemodynamic monitoring.
  • Global challenges in HF management, including implementation science, health policy, and equity of care.

The primary aim of this Special Issue is to stimulate the dissemination of cutting-edge research and promote interdisciplinary dialogue. Specifically, we seek to

  • Bridge translational science with bedside application;
  • Encourage the adoption of precision and personalized approaches to HF management;
  • Highlight innovations in technology and pharmacology that are reshaping treatment paradigms;
  • Foster international collaboration to address the unmet needs of HF patients worldwide.

For this Special Issue, original research, systematic reviews, clinical trials, and expert perspectives that explore the most relevant and timely topics in HF care are welcome to be submitted. Contributions will examine the effectiveness of novel therapeutics, the role of emerging biomarkers, strategies for optimizing care delivery, and the integration of AI-driven solutions into daily practice. By gathering insights from leaders across cardiology, nephrology, endocrinology, and digital health, this Special Issue aims to provide a multidisciplinary and future-oriented roadmap for improving outcomes in patients with HF.

Dr. Andre Rodrigues Durães
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure (HF)
  • cardiac biomarkers
  • guideline-directed medical therapy (GDMT)
  • risk stratification
  • HF phenotypes
  • HF management
  • digital health

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Published Papers (1 paper)

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Review

20 pages, 743 KB  
Review
Heart Failure and Cognitive Impairment Through the Lens of the Gut Microbiome: A Narrative Review
by Ali Reza Rahmani, Seyed Avid Madani, Ethan Aminov, Lasha Gogokhia, Travis Bench and Andreas Kalogeropoulos
J. Pers. Med. 2025, 15(12), 595; https://doi.org/10.3390/jpm15120595 - 3 Dec 2025
Viewed by 284
Abstract
Heart failure (HF) affects over 55 million individuals globally, with prevalence projected to exceed 11 million in the United States by 2050 and is increasingly recognized as a systemic disorder extending beyond hemodynamic dysfunction to encompass profound alterations in neural and gut physiology. [...] Read more.
Heart failure (HF) affects over 55 million individuals globally, with prevalence projected to exceed 11 million in the United States by 2050 and is increasingly recognized as a systemic disorder extending beyond hemodynamic dysfunction to encompass profound alterations in neural and gut physiology. Cognitive impairment affects nearly half of HF patients and represents a major determinant of morbidity, self-care capacity, and mortality. Recent advances suggest that the gut microbiome serves as a pivotal intermediary in the heart–brain crosstalk, influencing neurocognitive outcomes through inflammatory, metabolic, and neurohumoral pathways. Dysbiosis in HF disrupts intestinal barrier integrity, facilitating translocation of endotoxins and microbial metabolites such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids, which in turn modulate neuroinflammation, cerebral perfusion, and neuronal signaling. The gut–heart–brain axis provides an integrative framework linking HF and cognitive impairment pathophysiology through dysbiosis-driven systemic inflammation and metabolite dysregulation. Gut-derived biomarkers and microbiome-targeted interventions represent promising strategies for detection of early alterations and precision treatment, highlighting the urge for prospective, multi-omics studies to establish causality and therapeutic efficacy. This review synthesizes current evidence connecting gut microbiome dysbiosis and metabolite alterations to both HF and cognitive impairment pathophysiology and proposes translational strategies for integrating microbiome-targeted therapies in HF patients with cognitive dysfunction. Full article
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