Personalized Management and Treatment in Geriatrics

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 20 December 2026 | Viewed by 689

Special Issue Editors


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Guest Editor
Faculty of Health Sciences, Pontifical University of Salamanca, 37002 Salamanca, Castille and León, Spain
Interests: biochemistry; molecular biology; human genetics; clinical genetics; public Health
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Orthopaedic Surgery and Traumatology (Lead), University Hospital of Salamanca, Salamanca, Spain
2. Orthopaedic Surgery and Traumatology, Surgery Department, University of Salamanca (USAL), Salamanca, Spain
3. Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
Interests: orthogeriatrics; surgery; orthopedics; spine surgery; hip; knee
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aging population presents an unprecedented challenge for healthcare systems worldwide, demanding innovative approaches tailored to the unique needs of older adults. Personalised medicine in geriatrics leverages advancements in genetic profiling, biomarkers, and digital health technologies and seeks to tailor treatments and management strategies to the unique characteristics of each older person, integrating genetic data, biomarkers, environmental factors, and clinical conditions to optimise outcomes.

In recent decades, geriatric care has transitioned from standardized treatment models to more patient-centric approaches. Advances in precision medicine, pharmacogenomics, and artificial intelligence have accelerated this shift, allowing clinicians to move beyond generalized protocols and embrace therapies designed for the biological and environmental nuances of each individual.

This Special Issue aims at exploring the latest developments in personalized management and therapy for older adults. We seek to highlight novel methodologies in patient assessment, diagnostics, treatment customization, and holistic care models, ensuring that geriatric medicine evolves to meet the demands of an aging population. Our focus spans pharmaceutical adaptations, non-pharmacological interventions, predictive analytics, and policy implications for personalized healthcare. In addition, patient-centred models of care and prevention strategies designed to improve quality of life and promote autonomy are explored.

This collection will showcase pioneering research in geriatrics, from discovering biomarkers in ageing, modelling diagnostic tools to individualized drug regimens (including AI-driven) and integrated care frameworks. We welcome contributions detailing real-world applications, clinical trials, and interdisciplinary collaborations that push the boundaries of geriatric treatment paradigms.

We invite original research articles, meta-analyses, comprehensive reviews, and other types that advance the understanding and implementation of personalized approaches in geriatric care. Submissions should offer evidence-based insights, innovative methodologies, and practical recommendations for tailoring healthcare solutions to older adults.

We look forward to receiving your contributions and to advancing the conversation on personalized management and therapy in geriatrics.

Dr. Carmen da Casa
Prof. Dr. Juan F. Blanco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • geriatrics
  • personalized health care
  • artificial intelligence
  • comprehensive geriatric assessment
  • ageing
  • biomedical technology
  • health promotion
  • chronic disease management
  • rehabilitation
  • pharmacogenetics
  • neurodegenerative diseases

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Published Papers (1 paper)

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Review

25 pages, 798 KB  
Review
Personalised Approach to the Management of Older People with Type 2 Diabetes Mellitus—A Comprehensive Narrative Review
by Alan Sinclair, Mohammed Al-Banna, Roxana Tutunariu and Ahmed H. Abdelhafiz
J. Pers. Med. 2026, 16(4), 213; https://doi.org/10.3390/jpm16040213 - 13 Apr 2026
Viewed by 288
Abstract
The global population is ageing due to increased life expectancy, and the prevalence of diabetes is proportionally increasing. With advancing age, diabetes in older people is a complex condition due to associated morbidities and geriatric syndromes. As a result, the management of diabetes [...] Read more.
The global population is ageing due to increased life expectancy, and the prevalence of diabetes is proportionally increasing. With advancing age, diabetes in older people is a complex condition due to associated morbidities and geriatric syndromes. As a result, the management of diabetes in old age is challenging. Due to the wide heterogeneity of older people, diabetes management in this age group should be personalised. While strict targets are accepted in fit individuals, relaxed targets should be considered in patients with multiple morbidities and a high risk of hypoglycaemia. The development of frailty changes the metabolic profile of older people, and their insulin resistance and diabetes trajectory, which will have an impact on the choice of glucose-lowering agents and the goals of therapy. For example, intensive therapy, the use of SGLT-2 inhibitors and GLP-1RA, and tight targets should be continued in frail, sarcopenic, obese individuals due to their increased insulin resistance and cardiovascular risk. On the other hand, relaxed targets and deintensification of therapy should be considered in anorexic, malnourished, frail individuals with significant weight loss due to their low insulin resistance, low prevalence of cardiovascular risk factors, and high risk of hypoglycaemia. Annual reviews of older people with diabetes should include screening for frailty, depression and dementia for early diagnosis, and appropriate interventions. The introduction of continuous glucose monitoring is increasingly used in older people with diabetes and has the potential to reduce the incidence of hypoglycaemia. With the expectation of a continued increase in the prevalence of older people with diabetes, the use of mobile health may allow care delivery on a wider scale without the need for face-to-face appointments. In addition, there is a promising scope for artificial intelligence to achieve better diabetes outcomes. Future research is still required to expand the use of these technologies in older age groups. Full article
(This article belongs to the Special Issue Personalized Management and Treatment in Geriatrics)
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