Personalized Medicine in Oncology
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: closed (10 May 2021) | Viewed by 48148
Special Issue Editor
Interests: clinical trials; drug development; immune therapy; molecular targeted therapy; melanoma; biomedical ethics; medical oncology; outcomes research; healthcare management
Special Issue Information
Dear colleagues,
Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.
The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
Dr. Ari VanderWalde
Guest Editor
Manuscript Submission Information
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Keywords
- cancer genomic profiling
- hereditary cancer risk
- cancer biomarkers
- targeted therapy
- treatment decision-making
- next generation sequencing
- whole transcriptome
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