Personalized Diagnosis and Management of Stroke

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 25 July 2026 | Viewed by 783

Special Issue Editor


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Guest Editor
Department of Neurology, Faculty of Medical Sciences of Santa Casa de São Paulo, Dr. Cesário Motta Júnior Street 112, São Paulo 01221-020, Brazil
Interests: stroke; cerebrovascular disease; carotid disease

Special Issue Information

Dear Colleagues,

Cerebrovascular diseases (CVDs) are significant in the medical, social, and political spheres due to their prevalence and severity; they are among the first and third leading causes of death and disability in adults. One positive fact is that these are diseases with a great potential to be prevented through the creation of specific treatments.

In recent decades, significant knowledge about CVDs has been gathered, encompassing the fields of their prevention (primary and secondary), diagnosis (clinical, radiological, laboratory), etiology, treatment (acute and chronic phases), and rehabilitation. Several large, high-quality clinical trials have provided relevant information. This emerging knowledge shows that there is optimism in managing these patients and public health policies.

Up-to-date knowledge about their pathophysiology, clinical practice, and pharmacology allows for rapid and accurate diagnoses and effective treatment.

This Special Issue will address accepted and controversial aspects of the investigation and management of patients in this field of medicine, aiming to improve our knowledge and provide the best possible treatment.

Cerebrovascular diseases (CVDs) are of considerable significance in the medical, social, and political landscapes due to their widespread prevalence and severe implications for individuals and communities alike. These conditions rank among the foremost causes of death and disability in adults, highlighting the need for a proactive approach to both their prevention and treatment.

Over the past several decades, we have witnessed substantial advancements in our understanding of CVDs. Efforts toward their prevention, whether primary or secondary, alongside significant improvements in diagnostic approaches (including clinical, radiological, and laboratory methods), our understanding of their etiology, and treatment strategies for both acute and chronic phases, have all contributed to our growing knowledge. Numerous high-quality clinical trials have offered valuable insights that inform effective public health policies and practices.

With a strong foundation in current pathophysiological, clinical, and pharmacological knowledge, healthcare professionals are increasingly capable of providing timely and precise diagnoses and effective treatment options.

This Special Issue aims to explore today’s accepted and differing perspectives on the investigation and management of patients with CVDs. By enhancing our collective understanding of these critical issues, we strive to promote the best available treatment options, benefiting patients and improving community health outcomes.

We intend to publish articles that address different aspects of CVDs, including the results or design of clinical research and original research and reviews related to the following:

  • Experimental or clinical pathophysiology studies;
  • Epidemiology;
  • Risk factors;
  • Diagnosis;
  • Radiology;
  • Biological markers;
  • Neurointervention;
  • Neurointensive care;
  • Medical and surgical treatment;
  • Prevention;
  • Rehabilitation;
  • Reviews;
  • History.

Prof. Dr. Rubens José Gagliardi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • cerebrovascular disease
  • carotid disease
  • epidemiology

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Published Papers (1 paper)

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Research

13 pages, 2479 KB  
Article
Thrombus Imaging Features for Anterior Circulation Stroke: Their Impact on CTP Parameters and Natural Evolution of Infarct Progression
by Bruna G. Dutra, Heitor C. B. R. Alves, Vivian Gagliardi, Rubens J. Gagliardi, Felipe T. Pacheco, Antonio C. M. Maia, Jr. and Antônio J. da Rocha
J. Pers. Med. 2025, 15(10), 464; https://doi.org/10.3390/jpm15100464 - 1 Oct 2025
Viewed by 464
Abstract
Background/Objectives: The relationship between thrombus imaging features and the natural evolution of stroke remains poorly defined. We aimed to investigate the associations between thrombus characteristics on CT and perfusion parameters, as well as subsequent infarct progression, in untreated patients experiencing an anterior [...] Read more.
Background/Objectives: The relationship between thrombus imaging features and the natural evolution of stroke remains poorly defined. We aimed to investigate the associations between thrombus characteristics on CT and perfusion parameters, as well as subsequent infarct progression, in untreated patients experiencing an anterior circulation acute ischemic stroke (AIS). Methods: This retrospective analysis enrolled 81 untreated patients with AIS who underwent baseline non-contrast CT (NCCT), CT angiography (CTA), CT perfusion (CTP), and a follow-up NCCT. We evaluated the thrombus length, location, and clot burden score (CBS). CTP parameters included the ischemic core, hypoperfused tissue, and penumbra volumes. Infarct growth was the difference between the final infarct volume on a follow-up NCCT and the initial core volume on CTP. Univariate and multivariate regression models were performed. Results: Higher CBS values and shorter thrombi are associated with a reduced ischemic core (coefficients B of −3.9 and 0.88, p < 0.01), diminished hypoperfused tissue (coefficients B of −12.2 and 2.87, p < 0.001), and smaller penumbra volume (coefficients B of −7.9 and 1.99, p < 0.001). More distal occlusions were associated with smaller perfusion deficits. Importantly, a higher CBS and more distal thrombus location were significantly associated with a smaller final infarct volume and infarct growth volume. Conclusions: In untreated AIS patients, a lower thrombus burden (higher CBS, shorter length, distal location) is associated with more favorable baseline perfusion parameters and predicts a slower, less severe natural evolution of AIS. These findings underscore the prognostic value of baseline thrombus characteristics in determining the intrinsic course of a stroke. Full article
(This article belongs to the Special Issue Personalized Diagnosis and Management of Stroke)
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