Advances and Challenges in Personalized Medicine for Reproductive Health

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 20 March 2027 | Viewed by 1251

Special Issue Editors


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Guest Editor
Men’s Health Centre in Wroclaw, 53-151 Wroclaw, Poland
Interests: andrology; sexology; obesity treatment; rehabilitation medicine
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Guest Editor Assistant
The Clinical Department of Gynecologic Surgery and Oncology, Wroclaw Medical University, 50-556 Wroclaw, Poland
Interests: gynecology; sexology; obesity treatment; andrology

Special Issue Information

Dear Colleagues,

Personalized medicine for reproductive health is a new method of patient care based on using genetic, environmental, and lifestyle factors. Progress in technological innovation has significantly contributed to the development of personalized medicine for reproductive health. Those changes have allowed for more precise diagnostics and treatments for reproductive conditions. In obstetrics, personalized medicine offers significant improvements in diagnostics and the management of pregnancy complications such as pre-eclampsia, infections, gestational diabetes, and fetal growth restrictions. In gynecology, personalized medicine is transforming the management of endometriosis, uterine fibroids, infertility, and gynecological cancers. In andrology, the diagnosis of male infertility has been continuously optimized and the management of sexual dysfunction has been strengthened. By integrating genetic data, biomarkers, laboratory tests, and imaging techniques, healthcare providers can identify at-risk pregnancies or reproductive conditions earlier and implement targeted interventions.

We welcome original research articles and reviews that contribute to the development of personalized diagnostic tools, fetal risk assessment techniques, and individualized therapeutic approaches. Submissions exploring innovations in genetic testing, biomarker use, and patient-specific monitoring are especially encouraged, with the goal of improving reproductive health outcomes through customized medicine.

Prof. Dr. Dariusz Kałka
Guest Editor

Dr. Ewa Szuster
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • reproductive health
  • obstetrics
  • gynecology
  • andrology
  • personalized medicine
  • precision diagnosis
  • pregnancy
  • oncology
  • reproductive condition
  • women’s heath
  • men’s health

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Published Papers (2 papers)

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Research

11 pages, 1846 KB  
Article
Indocyanine Green Sentinel Lymph Node Mapping as a Tool for Personalized Surgical Management in Uterine Corpus Cancer: A Single-Center Comparative Study
by Krzysztof Nowak, Wiktor Bek, Maja Mrugała, Zofia Borowiec and Ewa Milnerowicz-Nabzdyk
J. Pers. Med. 2026, 16(3), 168; https://doi.org/10.3390/jpm16030168 - 18 Mar 2026
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Abstract
Objectives: This study aimed to investigate the usefulness and safety of sentinel lymph node (SLN) mapping in comparison to other types of lymph node dissection in patients with uterine corpus cancers. Methods: Retrospective data from 161 patients subjected to uterine corpus [...] Read more.
Objectives: This study aimed to investigate the usefulness and safety of sentinel lymph node (SLN) mapping in comparison to other types of lymph node dissection in patients with uterine corpus cancers. Methods: Retrospective data from 161 patients subjected to uterine corpus cancer staging with SLN mapping with indocyanine green (ICG) dye were collected. Results: SLN procedure was associated with a complication rate of 0%, a median number of dissected lymph nodes of 2 (range 0–13), and a median hospitalization following surgery of 5 (range:2–23) days. Systemic lymphadenectomy and one-sided pelvic lymph node resection were associated with the highest percentage of complications (12% and 25%; p = 0.0030), while the post-surgery course was uneventful for the selective lymphadenectomy group and SLN. Complication rates were the highest in patients with obesity and severe obesity (5.1% and 9.1%, respectively). The number of lymph nodes resected dropped numerically with increasing BMI. Successful ICG injection and SLN mapping were significantly more frequent in SLN procedures. Conclusions: Our study showed that SLN mapping was characterized by a low complication rate and short hospitalization following surgery, and obesity appeared to be related to a higher complication rate. Tailored surgical strategies and individualized patient selection are crucial for the success of SLN mapping; therefore, factors associated with successful SLN mapping with ICG need further exploration. Full article
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20 pages, 535 KB  
Article
Perceived Risk Perception of Future Cardiovascular Disease and Diabetes in the Postpartum Period
by Amin Heidarikakolaki, Siew Lim, Maureen Makama, Mingling Chen, Melinda J. Hutchesson, Cheryce L. Harrison, Helen Skouteris, Helena Teede and Lisa J. Moran
J. Pers. Med. 2026, 16(3), 137; https://doi.org/10.3390/jpm16030137 - 1 Mar 2026
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Abstract
Background/Objectives: Risk perception of future disease may play a role in supporting lifestyle change to prevent diabetes mellitus (DM) and cardiovascular disease (CVD). It is unknown how women in the postpartum period with different cardiometabolic conditions perceive their future risk of DM [...] Read more.
Background/Objectives: Risk perception of future disease may play a role in supporting lifestyle change to prevent diabetes mellitus (DM) and cardiovascular disease (CVD). It is unknown how women in the postpartum period with different cardiometabolic conditions perceive their future risk of DM and CVD, and whether this perception influences engagement in a healthy lifestyle. Methods: Cross-sectional study of women who delivered in the past five years (n = 497) living in Australia. Logistic regression analyses examined associations between history of pregnancy (gestational diabetes mellitus (GDM), gestational hypertension (GHP), pre-eclampsia, spontaneous preterm birth (PTB), small-for-gestational-age (SGA) infants), and non-pregnancy (polycystic ovary syndrome (PCOS), infertility) conditions with perceived risk of DM or CVD, and with lifestyle behaviours (physical activity, sedentary behaviour, and diet). Results: Overall, most participants had a low perceived risk of developing future DM (73.4%) and CVD (75.2%), which varied by condition type. History of GDM and GHP were associated with higher DM risk perception (OR 1.83, 95% CI 1.06, 3.15; OR 2.73, 95% CI 1.28, 5.84), whereas history of pre-eclampsia and DM were associated with higher CVD risk perception (OR 4.48, 95% CI 1.88, 10.62; OR 3.78, 95% CI 1.20, 11.88). History of PTB, SGA infant, PCOS, infertility, and lifestyle behaviours were not consistently associated with perceived risk of DM and CVD. Conclusions: Postpartum risk perception of developing future DM and CVD was low, even in the presence of female-specific cardiometabolic conditions. This highlights the need for greater postpartum support to enhance risk awareness and support a healthy lifestyle. Full article
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