The Correlation between Gut Microbiota and Cancers

Dear Colleagues,

The gut microbiota (GM) is one of the most complex and dense microbial ecosystems and is recognized for its pivotal role in human health. The GM and the host have a symbiotic relationship, which plays a crucial role in preserving the body's homeostasis. It affects a number of physiological processes, such as metabolism, vitamin synthesis, barrier homeostasis, defense against pathogens, immune system development and maturation, and hematopoiesis through intestinal and extraintestinal actions, thereby making it a vital organ. Disturbances in the dynamic interactions among GM populations, a phenomenon called dysbiosis, have been linked to several human diseases affecting the gut and various other organ systems.

Tumorigenesis is one of the most investigated pathologies associated with the GM. This connection has been observed not only with gastrointestinal cancers but also in tumors affecting different organ systems within the body. Research has highlighted the dual functionality of the GM in preventing cancer, promoting tumorigenesis, and influencing anti-cancer therapy. The GM can play a role either as a suppressor of tumors or as a factor contributing to oncogenesis. Despite prolonged investigation into the connection between cancer and GM, it is only partially characterized at the present.

Therefore, we are pleased to invite you to this Special Issue, which aims to focus on the impact of GM in cancer prevention and tumorigenesis, or examine the development of new anti-cancer therapeutic options, in order to fully understand the role of GM as an effective strategy against cancer that is not limited to the gastrointestinal tract. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

• The role of the GM in cancer prevention, tumorigenesis, and anti-cancer therapy;
• Potential strategies based on the GM for therapeutic or preventive interventions.

We look forward to receiving your contributions.

Dr. Georgia Saxami
Guest Editor

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• gut microbiota
• dysbiosis
• cancer
• cancer therapy
• GM as cancer biomarkers