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Kidney Disease: From Basic Research to Clinical Practice
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Kidney Disease: From Basic Research to Clinical Practice

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 3111

Special Issue Editor

Dr. Rafael Fernández Castillo

E-Mail Website
Guest Editor
Faculty of Health Sciences, University of Granada, 18071 Granada, Spain
Interests: renal failure; BMD; klotho; polycystic kidney disease; human study

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD), with a reported global prevalence of 11–13%, is a great challenge for health systems due to its economic and social implications. As it is a chronic and irreversible disease, treatment is aimed at slowing its progression. Serum creatinine quantification is the method of choice for diagnosis and classification; however, this test has limited clinical sensitivity, which has led to the search for new markers for timely diagnosis and monitoring. From this perspective, the use of metabolomics and animal models has allowed the identification and study of new metabolites, which are future biomarker candidates in clinical practice. The objective of this Special Issue is to collect articles that analyze the metabolomic profile of CKD, both in experimental and in vivo models. Those currently being investigated and new candidate markers are used to further improve the determination of kidney function. All studies that analyze markers in CKD are welcome, including clinical trials on metabolomics, as well as studies on genetics, biochemical markers in polycystic kidney disease and novel therapeutic approaches.

Dr. Rafael Fernández Castillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney biomarkers
  • dialysis
  • CKD treatment
  • chronic kidney disease
  • polycystic kidney disease
  • inflammation
  • bone mineral disorders
  • CKD anemia
  • kidney physiopathology
  • diabetic nephropathy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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14 pages, 4897 KiB  
Article
Determinants of Disease Progression in Autosomal Dominant Polycystic Kidney Disease
by Molla Asnake Kebede, Yewondwosen Tadesse Mengistu, Biruk Yacob Loge, Misikr Alemu Eshetu, Erkihun Pawlos Shash, Amenu Tolera Wirtu and Jickssa Mulissa Gemechu
J. Pers. Med. 2024, 14(9), 936; https://doi.org/10.3390/jpm14090936 - 2 Sep 2024
Cited by 1 | Viewed by 2229
Abstract
Background: Despite its severity, there has been a lack of adequate study on autosomal dominant polycystic kidney disease (ADPKD) in Ethiopia. This study assessed the clinical profile and determinant factors contributing to renal disease progression. Methods: A retrospective study was conducted on 114 [...] Read more.
Background: Despite its severity, there has been a lack of adequate study on autosomal dominant polycystic kidney disease (ADPKD) in Ethiopia. This study assessed the clinical profile and determinant factors contributing to renal disease progression. Methods: A retrospective study was conducted on 114 patients for 6 years in Addis Ababa. Patients with ADPKD who had follow-up visits at two health centers were included. Results: The mean age at diagnosis was 42.7 ± 12.7 years, with 43% reporting a positive family history of ADPKD. Approximately 22 patients (20%) developed end-stage renal disease, and 12 patients died. The mean estimated glomerular filtration rate at the initial visit was 72.4 mL/min/1.73 m2. The key risk factors associated with disease progression included younger age at diagnosis [adjusted Odds Ratio (aOR): 0.92, 95% CI: 0.87–0.98; p = 0.007], male gender (aOR: 4.5, 95% CI: 1.3–15.95, p = 0.017), higher baseline systolic blood pressure (aOR: 1.05, 95% CI: 1.01–1.10, p = 0.026), and the presence of comorbidities (aOR: 3.95, 95% CI: 1.10–14.33, p = 0.037). The progression of renal disease in ADPKD patients significantly correlates with age at diagnosis, gender, presence of comorbidities, and higher baseline systolic blood pressure. Conclusions: These findings underscore the importance of early detection and management of hypertension and comorbidities in ADPKD patients to mitigate disease progression and improve treatment outcomes. Full article
(This article belongs to the Special Issue Kidney Disease: From Basic Research to Clinical Practice)
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24 pages, 2869 KiB  
Systematic Review
Comparison of Depression in Hemodialysis, Peritoneal Dialysis, and Kidney Transplant Patients: A Systematic Review with Meta-Analysis
by Gloria M. Zaragoza-Fernández, José C. De La Flor, Verónica Fernández Abreu, Elisa Iglesias Castellano, Laura Rodríguez-Barbero Requena and Rafael Fernández Castillo
J. Pers. Med. 2025, 15(5), 179; https://doi.org/10.3390/jpm15050179 - 28 Apr 2025
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Abstract
Background: Depression is a common comorbidity in patients with chronic kidney disease undergoing renal replacement therapy. This meta-analysis compares depression prevalence across hemodialysis, peritoneal dialysis, and kidney transplantation, considering mean age, treatment duration, comorbidities (diabetes and hypertension), and measurement instruments. Methods: A systematic [...] Read more.
Background: Depression is a common comorbidity in patients with chronic kidney disease undergoing renal replacement therapy. This meta-analysis compares depression prevalence across hemodialysis, peritoneal dialysis, and kidney transplantation, considering mean age, treatment duration, comorbidities (diabetes and hypertension), and measurement instruments. Methods: A systematic review and meta-analysis of 16 studies involving 26,301 participants was conducted in accordance with PRISMA guidelines and registered in PROSPERO. It analyzed observational studies (2000–2024) on depression in patients receiving hemodialysis, peritoneal dialysis, or kidney transplantation. Data extraction included sample size, mean age, treatment duration, comorbidities, and measurement instruments. Random-effects models calculated the standardized mean differences and pooled prevalence estimates. Heterogeneity (Cochran’s Q, I2) and publication bias (Egger’s test) were assessed. Results: Depression prevalence was 35.56% (95% CI: 34.2–37.0%) in hemodialysis, 35.09% (95% CI: 33.5–36.7%) in peritoneal dialysis, and 25.33% (95% CI: 24.0–26.6%) in kidney transplant recipients. No significant differences were found between hemodialysis and peritoneal dialysis. Mean age, treatment duration, comorbidities, and measurement instruments were not significantly associated with depression prevalence. Conclusions: Kidney transplantation is linked to a lower depression prevalence than dialysis, while no significant differences exist between hemodialysis and peritoneal dialysis. These findings highlight the need to ensure timely transplantation access and enhance psychological support for dialysis patients. Further research should explore psychosocial factors and targeted interventions to improve mental health in this population. Full article
(This article belongs to the Special Issue Kidney Disease: From Basic Research to Clinical Practice)
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