Clinical Research of Precision Neuro-Oncology

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 827

Special Issue Editor

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Guest Editor
Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS and Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: brain and spine tumors; degenerative spine
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Special Issue Information

Dear Colleagues,

In the ever-evolving landscape of medical sciences, precision medicine has become a beacon of hope, offering tailored treatments that consider the unique genetic and molecular makeup of each patient. This paradigm shift has permeated various medical disciplines, with neuro-oncology standing at the forefront. This Special Issue is dedicated to exploring the dual dimensions of precision in neuro-oncology—surgical precision and molecular precision—and their collective impact on advancing patient care.

Surgical intervention plays a pivotal role in the management of brain and spine tumors, demanding unparalleled precision to navigate the intricate neural terrain. Neurooncological surgeries are inherently complex, requiring the utmost accuracy to maximize tumor resection while preserving neurological functions. Advances in imaging technologies, such as intraoperative magnetic resonance imaging, functional neuroimaging, neuro-navigation, and intraoperative neuromonitoring (IONM), along with new operating room tools such as the exoscope and the ultrasound aspirator, have revolutionized the surgical landscape, providing real-time insights into tumor boundaries and adjacent eloquent brain regions, enhancing precision surgery.

On the other hand, the molecular landscape of brain tumors is vast and diverse, demanding a nuanced understanding to pave the way for targeted and effective therapies. Through high-throughput sequencing technologies, researchers can unravel the genetic complexities underlying brain tumors, informing treatment decisions with unprecedented precision.

The synergy between surgical and molecular precision holds immense potential for advancing the field of neuro-oncology. Contributions that bridge these two dimensions—exploring how molecular information can guide surgical decision-making and vice versa—are particularly encouraged. By fostering interdisciplinary collaboration, we can optimize treatment strategies, minimize therapeutic gaps, and ultimately improve patient outcomes.

This Special Issue invites contributions focusing on two crucial aspects of precision in neuro-oncology: advancements in neurosurgical techniques, navigation systems, operating room tools, and intraoperative neuromonitoring, alongside cutting-edge research in molecular profiling and biomarker discovery. Authors are encouraged to share experiences and innovative approaches that enhance surgical precision, minimize invasiveness, and optimize patient outcomes. Discussions regarding challenges, such as technological limitations and the learning curve for novel procedures, are particularly welcomed. We also seek contributions showcasing pioneering research in molecular profiling, addressing the translation of findings into clinical practice and the integration of molecular information into treatment algorithms. This Special Issue provides a dynamic platform for the exchange of ideas, propelling neuro-oncology into the era of precision medicine.

Your insightful contributions will undoubtedly enrich our understanding of neuro-oncology and contribute to the ongoing transformation of patient care through precision medicine.

Dr. Giuseppe La Rocca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neuro-oncology
  • precision surgery
  • tailored treatment
  • innovation

Published Papers (1 paper)

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8 pages, 2759 KiB  
Brief Report
Combination of Tractography, Intraoperative Computed Tomography and 5-Aminolevulinic Acid Fluorescence in Stereotactic Brain Biopsies: A Case Series
by Edoardo Mazzucchi, Gianluca Galieri, Fabrizio Pignotti, Pierluigi Rinaldi, Giovanni Sabatino and Giuseppe La Rocca
J. Pers. Med. 2024, 14(4), 357; - 28 Mar 2024
Viewed by 657
Stereotactic needle biopsy (SNB) may be performed to collect tissue samples from lesions not amenable to open surgery. Integration of tractography, intraoperative imaging and fluorescence has been applied to reduce risk of complications and confirm the adequacy of bioptic specimens. Clinical and radiological [...] Read more.
Stereotactic needle biopsy (SNB) may be performed to collect tissue samples from lesions not amenable to open surgery. Integration of tractography, intraoperative imaging and fluorescence has been applied to reduce risk of complications and confirm the adequacy of bioptic specimens. Clinical and radiological data from patients who underwent stereotactic needle biopsy with the use of intraoperative CT, tractography and 5-aminolevulinic acid (5-ALA) fluorescence in a single Hospital were retrospectively reviewed to evaluate the accuracy and safety of the procedure. Seven patients were included in the study, and all the collected specimens showed red fluorescence. In six of them, the final histopathological diagnosis was grade 4 glioblastoma IDH-wt and in the other case it was Diffuse large B-Cell Lymphoma. The integration of tractography, intraoperative CT and 5-ALA as an intraoperative marker of diagnostic samples may be suggested in biopsies of suspect gliomas and lymphomas. The cost-effectiveness of the procedure should be evaluated in future studies. Full article
(This article belongs to the Special Issue Clinical Research of Precision Neuro-Oncology)
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