Molecular Mechanisms of Kidney Diseases
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 81
Special Issue Editors
Interests: kidney; genetics; gene expression; molecular mechanisms; nephropathy, diabetic nephropathy; apoptosis and fibrosis in renal tissue
Interests: kidney; CAKUT; molecular mechanisms; renal
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advancements have greatly enhanced our knowledge of the molecular basis of kidney diseases. These developments have elucidated the cellular and biochemical mechanisms involved in both acute and chronic forms of kidney damage.
Molecular disturbances affecting podocytes, tubular epithelial cells, and the glomerular basement membrane are central to many renal conditions. These disruptions are often driven by abnormal signaling pathways, oxidative stress, and immune-mediated inflammation. Also, dysfunctions in mitochondria, stress in the endoplasmic reticulum, and metabolic imbalances are increasingly recognized as key factors in promoting tissue fibrosis and declining kidney function.
Both genetic mutations and epigenetic modifications are now understood to play critical roles in inherited and acquired kidney disorders. Variants in genes encoding essential structural or regulatory proteins can increase susceptibility to specific nephropathies, while epigenetic factors can influence how these diseases develop and progress.
Progress in molecular and systems biology has made it possible to identify promising therapeutic targets, creating opportunities for early intervention with more precise treatments. Advanced techniques such as single-cell transcriptomics and proteomics are improving our ability to characterize the kidney's complex cell populations and how molecular changes differ by disease stage and individual patient.
We invite researchers to contribute original research articles and comprehensive reviews that explore the molecular basis of kidney diseases.
Relevant topics may include, but are not limited to, the following:
- Molecular signaling pathways in kidney injury and repair;
- Podocyte biology and glomerular barrier dysfunction;
- Mitochondrial and metabolic dysregulation in renal disease;
- Inflammatory and fibrotic mechanisms;
- Genetic and epigenetic contributors to kidney pathology;
- Novel molecular targets for therapy;
- Omics approaches and systems biology in nephrology.
We look forward to your contributions to this important and rapidly evolving field, which holds promise for more effective and personalized interventions in the future management of kidney diseases.
Dr. Sandra Kostic
Dr. Nela Kelam
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- kidney diseases
- kidney injury and repair
- genetics and epigenetics
- molecular targets
- personalized medicine
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