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Personalized Medicine in Orthopedics and Traumatology: Updates and Challenges
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Personalized Medicine in Orthopedics and Traumatology: Updates and Challenges

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 962

Special Issue Editors

Dr. Jan Reinhard

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Guest Editor
Department of Orthopaedics, Regensburg University, Kaiser-Karl V. Allee 3, 93077 Bad Abbach, Germany
Interests: shoulder surgery; total joint arthroplasty
Dr. Melanie Ardelt

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Guest Editor Assistant
1. Division of Orthopedics and Traumatology, University Hospital Krems, Mitterweg 10, 3500 Krems, Austria
2. Department of Orthopedics and Traumatology, Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria
Interests: spine surgery; periprosthetic joint infection; septic arthritis

Special Issue Information

Dear Colleagues,

There is ongoing discussion about optimizing treatment concepts in lumbar spine surgery and endoprosthetics to address the needs of both elderly patients and highly active individuals. It is increasingly clear that the traditional “one treatment fits all” approach is being replaced by individualized strategies tailored to each patient’s anatomical, functional, and clinical situation.

In the field of lumbar spine disorders, personalized surgical planning, implant selection, and rehabilitation protocols are gaining importance to improve outcomes in degenerative conditions, instability, and trauma. Similarly, in endoprosthetics, patient-specific implant positioning, risk-adjusted perioperative management, and individualized rehabilitation are becoming key components of modern treatment strategies.

This Special Issue aims to promote research and clinical applications that integrate patient-specific factors into decision-making and treatment workflows in lumbar spine surgery and joint replacement.

We welcome scholars to submit review articles and original research articles related to orthopedics and traumatology, and personalized medicine.

Dr. Jan Reinhard
Guest Editor

Dr. Melanie Ardelt
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized lumbar spine surgery
  • patient-specific implants in endoprosthetics
  • targeted drug delivery in spine and joint surgery
  • precision medicine in degenerative lumbar disorders
  • computer-assisted surgical planning
  • risk-adapted strategies in endoprosthetics
  • individualized rehabilitation after joint replacement
  • functional optimization in lumbar fusion and arthroplasty

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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17 pages, 2489 KB  
Review
Extracellular Vesicles in Osteonecrosis of the Femoral Head: An Integrated Review of Experimental and Bioinformatic Evidence
by Elvira Immacolata Parrotta, Giorgia Lucia Benedetto, Giovanni Cuda, Umile Giuseppe Longo, Arianna Carnevale, Olimpio Galasso, Giorgio Gasparini and Michele Mercurio
J. Pers. Med. 2026, 16(4), 208; https://doi.org/10.3390/jpm16040208 - 7 Apr 2026
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Abstract
Background/Objectives: Osteonecrosis of the femoral head (ONFH) is a progressive condition characterized by bone necrosis, impaired vascularization, and immune dysregulation, often resulting in femoral head collapse. Effective strategies to halt disease progression are limited. Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular [...] Read more.
Background/Objectives: Osteonecrosis of the femoral head (ONFH) is a progressive condition characterized by bone necrosis, impaired vascularization, and immune dysregulation, often resulting in femoral head collapse. Effective strategies to halt disease progression are limited. Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication and influence osteogenesis, angiogenesis, and immune responses. This review summarizes current evidence on EVs in ONFH and their translational potential. Methods: A structured narrative review of PubMed, Scopus, Web of Science, and Cochrane Central databases was conducted, including in vitro, preclinical, and clinical studies on EVs in ONFH. Data on EV sources, molecular cargo, signaling pathways, functional effects, and translational implications were qualitatively synthesized. No pooled statistical analysis was performed because the extracted data were heterogeneous. Bioinformatic analyses such as Gene Ontology, KEGG enrichment, and protein–protein interaction networks were also summarized. Results: In vitro, EVs from bone marrow mesenchymal stem cells, endothelial cells, and M2 macrophages modulate osteogenic differentiation, angiogenesis, and inflammation. Preclinical studies demonstrate that EV administration reduces femoral head necrosis, improves trabecular structure, and enhances neovascularization. Clinical studies have identified EV-associated molecules (SAA1, C4A, RPS8) linked to disease stage and the risk of femoral head collapse. Bioinformatic analyses connect EV cargo to pathways regulating bone formation, vascularization, immunity, and metabolism. Conclusions: EVs appear to play key roles in ONFH pathogenesis and may represent promising candidates for diagnostic and therapeutic applications. However, current clinical evidence remains limited and requires validation in larger studies. Nonetheless, heterogeneity and limited clinical data require standardized, longitudinal studies to validate their translational relevance. Full article
(This article belongs to the Special Issue Personalized Medicine in Orthopedics and Traumatology: Updates and Challenges)
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Other

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8 pages, 1603 KB  
Technical Note
Osteochondral Allograft Transplantation of the Knee Using a Low-Cost Custom Hybrid Workstation Instrumentation: Technical Note with an Illustrative Case
by Danijel Jurković, Stjepan Ivandić, Tomislav Čengić and Stipe Ćorluka
J. Pers. Med. 2026, 16(4), 187; https://doi.org/10.3390/jpm16040187 - 30 Mar 2026
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Abstract
Osteochondral allograft transplantation is a safe and effective surgical option for the treatment of large, focal, full-thickness chondral and osteochondral defects, particularly in young patients. We describe a low-cost new hybrid workstation for osteochondral allograft transplantation based on modified Ilizarov components and its [...] Read more.
Osteochondral allograft transplantation is a safe and effective surgical option for the treatment of large, focal, full-thickness chondral and osteochondral defects, particularly in young patients. We describe a low-cost new hybrid workstation for osteochondral allograft transplantation based on modified Ilizarov components and its clinical application in a patient with a large osteochondral femoral defect. The technique was applied in a 28-year-old male with chronic knee pain following two prior failed arthroscopic surgeries. Osteochondral allograft transplantation was performed using our modified workstation instrumentation. At the 8-month follow-up, MRI revealed excellent incorporation of the graft, and the patient reported ambulation without pain with return to physical activity. Our hybrid workstation presents a cost-effective alternative for graft preparation while maintaining a high standard of surgical care. Full article
(This article belongs to the Special Issue Personalized Medicine in Orthopedics and Traumatology: Updates and Challenges)
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