Towards Personalized Medicine in Breast Cancer

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 433

Special Issue Editor


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Guest Editor
Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea
Interests: breast cancer; thyroid cancer

Special Issue Information

Dear Colleagues,

Breast cancer is one of the most prevalent cancers among women and is recognized as a highly heterogeneous disease. Despite significant progress in early detection and treatment, challenges such as recurrence, metastasis, and drug resistance remain major obstacles. Advances in genomics, molecular biology, and bioinformatics have revolutionized the field, enabling personalized approaches to breast cancer management through tailored diagnostic tools and therapies.

This Special Issue of the Journal of Personalized Medicine invites high-quality contributions exploring personalized approaches across the spectrum of breast cancer care, including prevention, early detection, diagnosis, treatment, and survivorship. Topics of interest include innovative immunotherapies, targeted treatments, surgical advancements, resistance mechanisms, and translational research to improve patient outcomes. Studies addressing clinical, molecular, and bioinformatic perspectives are particularly welcome.

Dr. Eun Young Kim
Guest Editor

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Keywords

  • personalized medicine
  • breast cancer
  • targeted therapy
  • immunotherapy
  • pharmacogenomics
  • biomarkers
  • treatment resistance
  • early detection

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Published Papers (1 paper)

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9 pages, 210 KB  
Study Protocol
Identification of Chemotherapy-Induced Peripheral Neuropathy—A Self-Administered Scoring System Tested in Breast Cancer Survivors: Protocol of the NEURO-BREAC Trial
by Dirk Rades, Maria Karolin Streubel, Laura Doehring, Achim Rody and Martin Ballegaard
J. Pers. Med. 2025, 15(11), 554; https://doi.org/10.3390/jpm15110554 - 13 Nov 2025
Viewed by 221
Abstract
Background/Objectives: Many patients with breast cancer are treated with chemotherapy, including taxanes. These regimens bear a significant risk of potentially burdensome peripheral neuropathy. A scoring system supported by a neuropathy tracker, which can be self-administered by the patients, likely facilitates and speeds [...] Read more.
Background/Objectives: Many patients with breast cancer are treated with chemotherapy, including taxanes. These regimens bear a significant risk of potentially burdensome peripheral neuropathy. A scoring system supported by a neuropathy tracker, which can be self-administered by the patients, likely facilitates and speeds up the diagnosis of chemotherapy-induced peripheral neuropathy (CIPN). Before such a scoring system can be used, determination of the optimal cut-off score to discriminate between CIPN and no CIPN is necessary. The prospective NEURO-BREAC trial (NCT07148336) aims to identify the optimal cut-off score in patients treated with chemotherapy and adjuvant irradiation for breast cancer. Methods: The main goal of the NEURO-BREAC trial is to provide the optimal cut-off of a scoring system to discriminate between moderate to severe CIPN and no CIPN in breast cancer survivors previously treated with paclitaxel- or docetaxel-based chemotherapy and irradiation. The scores (0 to 44 points) are obtained by using a neuropathy tracker. This tracker is based on self-evaluation of symptoms and signs of CIPN by study participants. In addition, satisfaction of the patients with the scoring system is assessed. Twenty-four patients (sixteen patients with moderate to severe CIPN and eight patients without CIPN) are required for the Full Analysis Set. Assuming that about 5% of patients will not qualify for this set, 26 patients should be recruited for the NEURO-BREAC trial. The results of this trial are considered an important step for the development of a scoring system contributing to the identification of CIPN in breast cancer patients. Full article
(This article belongs to the Special Issue Towards Personalized Medicine in Breast Cancer)
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