Gastrointestinal Cancer and Other Gastrointestinal Disease: Molecular Biology, Targeted Therapy and Prognostic Value

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Molecular Targeted Therapy".

Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 449

Special Issue Editor


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Guest Editor
University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Interests: cytopathology; anatomic pathology; clinical pathology

Special Issue Information

Dear Colleagues,

Gastrointestinal diseases refer to diseases of the digestive tract consisting of the esophagus, stomach, small intestine, large intestine and rectum, liver, pancreas, and gallbladder. Gastrointestinal diseases such as eosinophilic esophagitis, Barrett’s esophagus, gastroesophageal reflux disease, gallstones, inflammatory bowel syndrome, irritable bowel syndrome and gastrointestinal tumors are common gastrointestinal diseases and they pose a significant threat to human health. Among gastrointestinal tumors, colorectal cancer and gastric cancer are the third and fifth most common cancer types, respectively, and one of the fifth leading causes of cancer-related deaths worldwide. Therefore, early diagnosis provides patients with the best chance of treatment and greatly improves their prognosis.

Recent advances in current cellular and molecular biology have greatly elucidated the pathophysiology of the gastrointestinal tract from injury and repair to reperfusion injury to chronic inflammatory states. New techniques and work are helping us identify novel mechanisms of gastrointestinal disease pathophysiology, thereby providing potential new targets for therapeutic intervention.

We invite you to contribute to the Special Issue entitled “Gastrointestinal Cancer and Other Gastrointestinal Disease: Molecular Biology, Targeted Therapy and Prognostic Value”. This Special Issue will showcase the exciting new work in this field that may herald future treatments. We hope you will consider contributing a manuscript to this Special Issue.

Dr. Stanley Lightfoot
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal disease
  • gastrointestinal cancer
  • targeted therapy
  • prognostic value
  • personalized medicine
  • functional disorders
  • inflammation

Published Papers (1 paper)

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Review

14 pages, 1004 KiB  
Review
The cGAS/STING Pathway—A New Potential Biotherapeutic Target for Gastric Cancer?
by Mengxiang Tian, Shuai Zhang and Fengbo Tan
J. Pers. Med. 2024, 14(7), 736; https://doi.org/10.3390/jpm14070736 - 9 Jul 2024
Viewed by 289
Abstract
Gastric cancer ranks among the top five deadliest tumors worldwide, both in terms of prevalence and mortality rates. Despite mainstream treatments, the efficacy in treating gastric cancer remains suboptimal, underscoring the urgency for novel therapeutic approaches. The elucidation of tumor immunosuppressive microenvironments has [...] Read more.
Gastric cancer ranks among the top five deadliest tumors worldwide, both in terms of prevalence and mortality rates. Despite mainstream treatments, the efficacy in treating gastric cancer remains suboptimal, underscoring the urgency for novel therapeutic approaches. The elucidation of tumor immunosuppressive microenvironments has shifted focus towards cancer biotherapeutics, which leverage the patient’s immune system or biologics to target tumor cells. Biotherapy has emerged as a promising alternative for tumors resistant to traditional chemotherapy, radiation, and immunotherapy. Central to this paradigm is the cGAS-STING pathway, a pivotal component of the innate immune system. This pathway recognizes aberrant DNA, such as that from viral infections or tumor cells, and triggers an immune response, thereby reshaping the immunosuppressive tumor microenvironment into an immune-stimulating milieu. In the context of gastric cancer, harnessing the cGAS-STING pathway holds significant potential for biotherapeutic interventions. This review provides a comprehensive overview of the latest research on cGAS-STING in gastric cancer, including insights from clinical trials involving STING agonists. Furthermore, it assesses the prospects of targeting the cGAS-STING pathway as a novel biotherapeutic strategy for gastric cancer. Full article
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