Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 641

Special Issue Editors


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Guest Editor
Endoscopic Surgery Unit, 1(st) Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, "Alexandra" General Hospital, Vasilissis Sofias Avenue 80, 11528 Athens, Greece
Interests: obstetrics and gynecology; endoscopic surgery; gynecological endoscopy; hysteroscopy

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Guest Editor
Urogynecology Unit, 1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, “Alexandra” General Hospital, Vasilissis Sofias Avenue 80, 11528 Athens, Greece
Interests: gynaecological surgery; urogynecology; hysterectomy; pelvic reconstructive surgery
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Special Issue Information

Dear Colleagues,

We are pleased to invite your contributions to a Special Issue titled “Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions”, aimed at advancing the application of precision medicine within gynecological practices. This issue will serve as a platform for showcasing groundbreaking research and innovations that personalize diagnostic and therapeutic approaches in gynecological endoscopy.

Submissions should focus on the integration of cutting-edge technologies and data-driven insights that enhance patient-specific care. We encourage papers that detail the use of genomic profiling, real-time imaging, and AI algorithms to refine diagnostic accuracy and surgical precision, thereby improving treatment outcomes and patient quality of life.

We welcome original research and reviews on topics including, but not limited to, the following:

  • Personalized diagnostic tools: innovations in imaging and biomarker identification;
  • Tailored surgical techniques: advances in minimally invasive and robotic surgeries tailored to individual patient profiles;
  • Post-operative care and monitoring: personalized approaches to enhance recovery and reduce recurrence;
  • Ethical, legal, and social implications: considerations of privacy, consent, and equity in personalized gynecological care.

This Special Issue aims to foster a comprehensive understanding of how precision medicine can be effectively incorporated into gynecological endoscopy to offer tailored, effective, and less invasive treatment options.

We look forward to receiving your contributions that explore these themes and help shape the future of gynecological healthcare through precision medicine.

Dr. Nikolaos Kathopoulis
Dr. Dimitrios Zacharakis
Guest Editors

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Keywords

  • gynecological endoscopy
  • minimally invasive and robotic surgeries
  • personalized gynecological care
  • gynecological healthcare
  • personalized diagnosis
  • genomic profiling
  • real-time imaging
  • AI algorithms
  • biomarker identification
 

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Published Papers (1 paper)

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14 pages, 2322 KiB  
Systematic Review
Effectiveness of A Levonorgestrel-Releasing Intrauterine System Versus Hysteroscopic Treatment for Abnormal Uterine Bleeding in Women with Cesarean Scar Defects: A Systematic Review and Meta-Analysis
by Athanasios Douligeris, Nikolaos Kathopoulis, Konstantinos Kypriotis, Dimitrios Zacharakis, Anastasia Prodromidou, Anastasia Mortaki, Ioannis Chatzipapas, Themos Grigoriadis and Athanasios Protopapas
J. Pers. Med. 2025, 15(3), 117; https://doi.org/10.3390/jpm15030117 - 18 Mar 2025
Viewed by 390
Abstract
Background/Objectives: To assess the effectiveness of the levonorgestrel-releasing intrauterine device (LNG-IUD) compared to hysteroscopic resection for managing women with symptomatic cesarean scar defects (CSDs). Methods: This systematic review and meta-analysis followed PRISMA guidelines. A comprehensive search of four electronic databases was [...] Read more.
Background/Objectives: To assess the effectiveness of the levonorgestrel-releasing intrauterine device (LNG-IUD) compared to hysteroscopic resection for managing women with symptomatic cesarean scar defects (CSDs). Methods: This systematic review and meta-analysis followed PRISMA guidelines. A comprehensive search of four electronic databases was conducted to identify studies comparing LNG-IUD with hysteroscopic management for symptomatic CSDs. Studies reporting outcomes of bleeding and spotting days and effectiveness rates were included. Quality assessment was performed using the ROBINS-I and RoB-2 tools. Results: Three studies involving 344 patients met the inclusion criteria. At 6 months, LNG-IUD use significantly reduced total bleeding days (MD −4.13; 95% CI: −5.17 to −3.09; p < 0.00001) and spotting days (MD 1.90; 95% CI: 0.43 to 3.37; p = 0.01) compared to hysteroscopic treatment. By 12 months, LNG-IUD demonstrated superior effectiveness (OR 3.46; 95% CI: 1.53 to 7.80; p = 0.003), with fewer total bleeding days (MD −5.69; 95% CI: −6.55 to −4.83; p < 0.00001) and spotting days (MD 3.09; 95% CI: 1.49 to 4.69; p = 0.0002). Approximately 50% of LNG-IUD users experienced amenorrhea within 1 year. Conclusions: LNG-IUD offers a minimally invasive and effective alternative to hysteroscopic resection for women with symptomatic CSD and no desire for future pregnancies. Its role should be considered in clinical practice, but further research is needed to validate these findings and define its long-term benefits and limitations. Full article
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