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Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored...
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Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 760

Special Issue Editors

Dr. Nikolaos Kathopoulis

E-Mail Website
Guest Editor
Endoscopic Surgery Unit, 1(st) Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, "Alexandra" General Hospital, Vasilissis Sofias Avenue 80, 11528 Athens, Greece
Interests: obstetrics and gynecology; endoscopic surgery; gynecological endoscopy; hysteroscopy
Dr. Dimitrios Zacharakis

E-Mail Website
Guest Editor
Urogynecology Unit, 1st Department of Obstetrics & Gynecology, “Alexandra” General Hospital, National and Kapodistrian University of Athens, Lourou 2, 11528 Athens, Greece
Interests: pelvic organ prolapse; urinary incontinence; gynecologic surgery; minimally invasive gynecology
Special Issues, Collections and Topics in MDPI journals
Dr. Athanasios Douligeris

E-Mail Website
Guest Editor
Minimally Invasive Gynecologic Surgery Unit, 1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, “Alexandra” General Hospital, Vasilissis Sofias Avenue 80, 11528 Athens, Greece
Interests: gynecological surgery; urogynecology; laparoscopic surgery; pelvic reconstructive surgery; female urology; reproductive medicine; endometriosis; minimally invasive surgery; robotic surgery

Special Issue Information

Dear Colleagues,

We are pleased to invite your contributions to a Special Issue titled “Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions”, aimed at advancing the application of precision medicine within gynecological practices. This issue will serve as a platform for showcasing groundbreaking research and innovations that personalize diagnostic and therapeutic approaches in gynecological endoscopy.

Submissions should focus on the integration of cutting-edge technologies and data-driven insights that enhance patient-specific care. We encourage papers that detail the use of genomic profiling, real-time imaging, and AI algorithms to refine diagnostic accuracy and surgical precision, thereby improving treatment outcomes and patient quality of life.

We welcome original research and reviews on topics including, but not limited to, the following:

  • Personalized diagnostic tools: innovations in imaging and biomarker identification;
  • Tailored surgical techniques: advances in minimally invasive and robotic surgeries tailored to individual patient profiles;
  • Post-operative care and monitoring: personalized approaches to enhance recovery and reduce recurrence;
  • Ethical, legal, and social implications: considerations of privacy, consent, and equity in personalized gynecological care.

This Special Issue aims to foster a comprehensive understanding of how precision medicine can be effectively incorporated into gynecological endoscopy to offer tailored, effective, and less invasive treatment options.

We look forward to receiving your contributions that explore these themes and help shape the future of gynecological healthcare through precision medicine.

Dr. Nikolaos Kathopoulis
Dr. Dimitrios Zacharakis
Dr. Athanasios Douligeris
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological endoscopy
  • minimally invasive and robotic surgeries
  • personalized gynecological care
  • gynecological healthcare
  • personalized diagnosis
  • genomic profiling
  • real-time imaging
  • AI algorithms
  • biomarker identification
 

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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19 pages, 696 KiB  
Review
PRP Therapy for Stress Urinary Incontinence and Pelvic Organ Prolapse: A New Frontier in Personalized Treatment?
by Anna Pitsillidi, Laura Vona, Stefano Bettocchi, Sven Schiermeier and Günter Karl Noé
J. Pers. Med. 2025, 15(6), 214; https://doi.org/10.3390/jpm15060214 - 22 May 2025
Abstract
Background: Pelvic organ prolapse (POP) and stress incontinence (SUI) are very common medical conditions, affecting women’s quality of life worldwide. Current surgical and conservative therapies often yield variable outcomes and carry risks of complications or recurrence. Platelet-rich plasma (PRP) has emerged as a [...] Read more.
Background: Pelvic organ prolapse (POP) and stress incontinence (SUI) are very common medical conditions, affecting women’s quality of life worldwide. Current surgical and conservative therapies often yield variable outcomes and carry risks of complications or recurrence. Platelet-rich plasma (PRP) has emerged as a promising regenerative approach in various medical disciplines. Its application in urogynecology remains relatively new and emerging. The objective of this study was to review and consolidate existing evidence regarding the application of PRP injections for treating POP and/or SUI. Methods: This scoping review was conducted in accordance with the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR). The search strategy included MEDLINE (PubMed), Web of Science, and Scopus databases, covering articles published up to February 2025, with no restrictions on publication date. Results: We included in our review a total of 13 manuscripts and 320 patients at the end of the screening process. A total of ten SUI studies, comprising 273 patients, and three POP studies, involving 47 patients, satisfied all the review criteria. Both clinical entities reported high subjective improvement following PRP treatment. Moreover, PRP appeared to have no significant adverse effects. Conclusions: Our scoping review suggests that PRP may have potential benefits in the treatment of POP and SUI. Nevertheless, the current evidence on its application in this area remains limited. Therefore, well-designed, large-scale randomized controlled trials (RCTs) with extended follow-up periods are urgently needed, in the era of personalized medicine. Full article
(This article belongs to the Special Issue Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions)
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Other

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14 pages, 2322 KiB  
Systematic Review
Effectiveness of A Levonorgestrel-Releasing Intrauterine System Versus Hysteroscopic Treatment for Abnormal Uterine Bleeding in Women with Cesarean Scar Defects: A Systematic Review and Meta-Analysis
by Athanasios Douligeris, Nikolaos Kathopoulis, Konstantinos Kypriotis, Dimitrios Zacharakis, Anastasia Prodromidou, Anastasia Mortaki, Ioannis Chatzipapas, Themos Grigoriadis and Athanasios Protopapas
J. Pers. Med. 2025, 15(3), 117; https://doi.org/10.3390/jpm15030117 - 18 Mar 2025
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Abstract
Background/Objectives: To assess the effectiveness of the levonorgestrel-releasing intrauterine device (LNG-IUD) compared to hysteroscopic resection for managing women with symptomatic cesarean scar defects (CSDs). Methods: This systematic review and meta-analysis followed PRISMA guidelines. A comprehensive search of four electronic databases was [...] Read more.
Background/Objectives: To assess the effectiveness of the levonorgestrel-releasing intrauterine device (LNG-IUD) compared to hysteroscopic resection for managing women with symptomatic cesarean scar defects (CSDs). Methods: This systematic review and meta-analysis followed PRISMA guidelines. A comprehensive search of four electronic databases was conducted to identify studies comparing LNG-IUD with hysteroscopic management for symptomatic CSDs. Studies reporting outcomes of bleeding and spotting days and effectiveness rates were included. Quality assessment was performed using the ROBINS-I and RoB-2 tools. Results: Three studies involving 344 patients met the inclusion criteria. At 6 months, LNG-IUD use significantly reduced total bleeding days (MD −4.13; 95% CI: −5.17 to −3.09; p < 0.00001) and spotting days (MD 1.90; 95% CI: 0.43 to 3.37; p = 0.01) compared to hysteroscopic treatment. By 12 months, LNG-IUD demonstrated superior effectiveness (OR 3.46; 95% CI: 1.53 to 7.80; p = 0.003), with fewer total bleeding days (MD −5.69; 95% CI: −6.55 to −4.83; p < 0.00001) and spotting days (MD 3.09; 95% CI: 1.49 to 4.69; p = 0.0002). Approximately 50% of LNG-IUD users experienced amenorrhea within 1 year. Conclusions: LNG-IUD offers a minimally invasive and effective alternative to hysteroscopic resection for women with symptomatic CSD and no desire for future pregnancies. Its role should be considered in clinical practice, but further research is needed to validate these findings and define its long-term benefits and limitations. Full article
(This article belongs to the Special Issue Precision Medicine in Gynecological Endoscopy: From Personalized Diagnosis to Tailored Surgical Interventions)
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