Novel Advances in Personalized Hepatobiliary Surgery

Dear Colleagues,

We are currently experiencing an era where the treatment of hepatobiliary malignancies, both primary and secondary, is becoming increasingly complex and integrated. The rise of target therapies, the increasing use of loco-regional therapies (e.g., thermoablation, radiofrequency, chemo- and radio-embolization, and intra-arterial therapies), and finally the advent of liver transplantation as a viable treatment option in secondary malignancies. Surgery remains the cornerstone of treatment, and we are observing its rapid and progressive evolution. In addition, the integration of these therapies with molecular information is revolutionizing therapeutic indications, which are becoming more and more tailored. All of this markedly improves patient prognosis but, at the same time, complicates treatment decisions for patients with hepatobiliary malignancies. In this Special Issue, we invite all researchers to contribute relevant clinical or basic studies regarding hepatobiliary primitive or secondary tumors (hepatocarcinoma, cholangiocarcinoma, colorectal liver metastasis, neuroendocrine liver metastasis, and non-colorectal, non-neuroendocrine liver metastasis) focused on integrated therapy of these malignancies, the use of prognostic molecular biomarkers, new therapeutic indications, new treatment frontiers, borderline therapeutic choices in complex cases, treatment of complex recurrences, and modern application of molecular biomarkers. Original and review articles (systematic and narrative approaches) are also welcome. Papers that meet the criteria of the peer review process will be accepted for publication. We hope that this Special Issue will enrich our knowledge of hepatobiliary tumors and further select the right patients to receive optimal management to improve the quality and outcomes of cancer patient care in surgery.

Finally, I would like to thank all our distinguished authors for their excellent contributions.

Dr. Edoardo Maria Muttillo
Prof. Dr. Fabrizio Panaro
Dr. Fabio Giannone
Guest Editors

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