Special Issue "Morphological Development of Candida"

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".

Deadline for manuscript submissions: 31 March 2023 | Viewed by 392

Special Issue Editor

Dr. Jia-Ching Shieh
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Guest Editor
1. Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 40201, Taiwan
2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
3. Immunology Research Center, Chung Shan Medical University, Taichung City 40201, Taiwan
Interests: Candida albicans; morphological plasticity; microbial molecular biology; epigenetics
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Special Issue Information

Dear Colleagues,

Candida albicans is an opportunistic human fungal pathogen. It usually inhabits a human host as a commensal organism but can cause life-threatening infections. The molecular mechanism underlying C. albicans morphological development is vital as it ties with virulence. Notably, an eminent number of virulence genes is co-regulated with morphogenesis, highlighting that C. albicans commensalism and pathogenesis lie in the development programs of multimorphism. While genetics and epigenetics play a role in C. albicans morphogenesis, switching among diverse morphological forms is influenced by many environmental factors, which trigger various signaling pathways and lead to alteration of many cellular functions. Other Candida species present morphogenesis traits common or unique to C. albicans. Understanding the morphological development in Candida is essential to fight against Candida infection.

This SI intends to present new data on morphological development of Candida albicans and other Candida species. Original articles and reviews are welcome.

Dr. Jia-Ching Shieh
Guest Editor

Manuscript Submission Information

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Keywords

  • Candida
  • morphological development
  • morphogenesis
  • genetics
  • epigenetics
  • environmental factors
  • signaling pathways

Published Papers (1 paper)

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Research

Article
The Cdc25 and Ras1 Proteins of Candida albicans Influence Epithelial Toxicity in a Niche-Specific Way
J. Fungi 2023, 9(2), 201; https://doi.org/10.3390/jof9020201 - 04 Feb 2023
Viewed by 255
Abstract
The PKA pathway is a signaling pathway involved in virulence in Candida albicans. This mechanism can be activated via addition of glucose and activation involves at least two proteins, namely Cdc25 and Ras1. Both proteins are involved in specific virulence traits. However, [...] Read more.
The PKA pathway is a signaling pathway involved in virulence in Candida albicans. This mechanism can be activated via addition of glucose and activation involves at least two proteins, namely Cdc25 and Ras1. Both proteins are involved in specific virulence traits. However, it is not clear if Cdc25 and Ras1 also affect virulence independently of PKA. C. albicans holds a second, atypical, Ras protein, Ras2, but its function in PKA activation is still unclear. We investigated the role of Cdc25, Ras1, and Ras2 for different in vitro and ex vivo virulence characteristics. We show that deletion of CDC25 and RAS1 result in less toxicity towards oral epithelial cells, while deletion of RAS2 has no effect. However, toxicity towards cervical cells increases in both the ras2 and the cdc25 mutants while it decreases in a ras1 mutant compared to the WT. Toxicity assays using mutants of the transcription factors downstream of the PKA pathway (Efg1) or the MAPK pathway (Cph1) show that the ras1 mutant shows similar phenotypes as the efg1 mutant, whereas the ras2 mutant shows similar phenotypes as the cph1 mutant. These data show niche-specific roles for different upstream components in regulating virulence through both signal transduction pathways. Full article
(This article belongs to the Special Issue Morphological Development of Candida)
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