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Proteomic Studies of Pathogenic Fungi and Hosts
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Proteomic Studies of Pathogenic Fungi and Hosts

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1495

Special Issue Editor

Dr. Lucélia Santi

E-Mail Website
Guest Editor
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Interests: host-pathogen interaction; Cryptococcus sp.; immune evasion; antimicrobial; biofilm

Special Issue Information

Dear Colleagues,

As you may be aware, the World Health Organization has recently released the Fungal Priority Pathogens List, highlighting fungal pathogens such as Cryptococcus neoformans, Candida auris, and Aspergillus fumigatus as significant global threats. Since proteomics can enhance our understanding of fungal infections and host interactions at the molecular level, Journal of Fungi is launching a Special Issue on “Proteomic Studies of Pathogenic Fungi and Hosts”. We invite submissions of research articles and reviews that focus on proteomic studies of fungal pathogens and their hosts. Studies exploring the role of proteomics in elucidating fungal virulence and host immune responses are also welcome. By examining these interactions at the molecular level, this Special Issue will identify potential biomarkers and therapeutic targets, ultimately advancing our ability to diagnose, treat, and manage fungal infections more effectively and thereby improve patient outcomes.

Dr. Lucélia Santi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogenic fungus
  • proteomics
  • host–pathogen interaction

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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16 pages, 1512 KiB  
Article
Proteomic Approach to Study the Effect of Pneumocystis jirovecii Colonization in Idiopathic Pulmonary Fibrosis
by Jonás Carmona-Pírez, Rocío Salsoso, Eléna Charpentier, Cinta Olmedo, Francisco J. Medrano, Lucas Román, Carmen de la Horra, Yaxsier de Armas, Enrique J. Calderón and Vicente Friaza
J. Fungi 2025, 11(2), 102; https://doi.org/10.3390/jof11020102 - 29 Jan 2025
Viewed by 900
Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and interstitial disease with an unclear cause, believed to involve genetic, environmental, and molecular factors. Recent research suggested that Pneumocystis jirovecii (PJ) could contribute to disease exacerbations and severity. This article explores how PJ colonization [...] Read more.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and interstitial disease with an unclear cause, believed to involve genetic, environmental, and molecular factors. Recent research suggested that Pneumocystis jirovecii (PJ) could contribute to disease exacerbations and severity. This article explores how PJ colonization might influence the pathogenesis of IPF. We performed a proteomic analysis to study the profile of control and IPF patients, with/without PJ. We recruited nine participants from the Virgen del Rocio University Hospital (Seville, Spain). iTRAQ and bioinformatics analyses were performed to identify differentially expressed proteins (DEPs), including a functional analysis of DEPs and of the protein–protein interaction networks built using the STRING database. We identified a total of 92 DEPs highlighting the protein vimentin when comparing groups. Functional differences were observed, with the glycolysis pathway highlighted in PJ-colonized IPF patients; as well as the pentose phosphate pathway and miR-133A in non-colonized IPF patients. We found 11 protein complexes, notably the JAK-STAT signaling complex in non-colonized IPF patients. To our knowledge, this is the first study that analyzed PJ colonization’s effect on IPF patients. However, further research is needed, especially on the complex interactions with the AKT/GSK-3β/snail pathway that could explain some of our results. Full article
(This article belongs to the Special Issue Proteomic Studies of Pathogenic Fungi and Hosts)
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Review

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16 pages, 1645 KiB  
Review
Proteomic Strategies on the Management of Phytopathogenic Fungi
by Aldrey Nathália Ribeiro Corrêa, Ana Carolina Ritter and Adriano Brandelli
J. Fungi 2025, 11(4), 306; https://doi.org/10.3390/jof11040306 - 11 Apr 2025
Viewed by 312
Abstract
Phytopathogenic fungi are important causative agents of many plant diseases, resulting in substantial economic losses in agriculture. Proteomics has become one of the most relevant high-throughput technologies, and current advances in proteomic methodologies have been helpful in obtaining massive biological information about several [...] Read more.
Phytopathogenic fungi are important causative agents of many plant diseases, resulting in substantial economic losses in agriculture. Proteomics has become one of the most relevant high-throughput technologies, and current advances in proteomic methodologies have been helpful in obtaining massive biological information about several organisms. This review outlines recent advances in mass spectrometry-based proteomics applied to the study of phytopathogenic fungi, including analytical platforms such as LC-MS/MS and MALDI-TOF, as well as quantitative strategies including TMT, iTRAQ, and label-free quantification. Key findings are presented from studies exploring infection-related protein expression, virulence-associated factors, post-translational modifications, and fungal adaptation to chemical fungicides, antimicrobial peptides, and biological control agents. Proteomic analyses have also elucidated mechanisms of resistance, oxidative stress response, and metabolic disruption following exposure to natural products, including essential oils and volatile organic compounds. The proteomic approach enables a comprehensive understanding of fungal biology by identifying proteins related to pathogenicity, stress adaptation, and antifungal resistance, while also facilitating the discovery of molecular targets and natural compounds for the development of sustainable antifungal strategies that reduce risks to human health and the environment. Full article
(This article belongs to the Special Issue Proteomic Studies of Pathogenic Fungi and Hosts)
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