Bioactive Compounds Derived from Ocean Algae: Applications and Potential

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Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA
Interests: CRISPR; microfluidic systems; pathogen detection; secondary metabolites; tissue culture
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Special Issue Information

Dear Colleagues,

Marine algae are a rich and valuable source of bioactive compounds with growing potential across a wide range of industries, including medicine, nutrition, cosmetics, and agriculture. This Special Issue, “Bioactive Compounds Derived from Ocean Algae: Applications and Potential”, highlights the recent research on the discovery and application of these valuable molecules that are known for their diverse biological activities, including antioxidants, anti-inflammatory, antimicrobial, antiviral, and anticancer properties. As demand increases for natural and eco-friendly alternatives, ocean algae offer opportunities for innovation in health and sustainability. This Special Issue welcomes original research, reviews, and case studies exploring novel extraction techniques, mechanisms of action, biotechnological production, and real-world uses. It also aims to shed light on current challenges, such as improving bioavailability and scaling up production for commercial use. By bringing together insights from across disciplines, this collection hopes to extend our knowledge in algae-based bioactive and support their development into impactful, real-world applications.

Dr. Ali Parsaeimehr
Guest Editor

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Keywords

  • marine algae
  • bioactive compounds
  • natural products
  • pharmacological applications
  • algal biotechnology

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Published Papers (1 paper)

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Research

18 pages, 7011 KB  
Article
Comparative Untargeted LC-HRMS-Based Metabolomic Profiling of Gracilaria edulis (Gracilariales, Rhodophyta) from Three Different Beaches Using Sequential Solvent Extraction
by Fitria Nurul Alfiah, Riyanti, Hamdan Syakuri, Dyahruri Sanjayasari, Riviani, Till F. Schäberle, Maria Alexandra Patras, Dicky Harwanto, Jae-Suk Choi and Maria Dyah Nur Meinita
J. Mar. Sci. Eng. 2026, 14(7), 672; https://doi.org/10.3390/jmse14070672 - 3 Apr 2026
Viewed by 620
Abstract
Gracilaria edulis, a red seaweed that is widely known as an agar-producing seaweed, has a unique biosynthetic pathway for producing bioactive compounds. However, most of the bioactive compounds of this species have not explored yet. The environmental conditions as well as the [...] Read more.
Gracilaria edulis, a red seaweed that is widely known as an agar-producing seaweed, has a unique biosynthetic pathway for producing bioactive compounds. However, most of the bioactive compounds of this species have not explored yet. The environmental conditions as well as the extraction method might influence the bioactive compound production. Hence, this study aimed to explore untargeted liquid chromatography–high resolution mass spectrometry (LCHRMS)-based metabolomics profiling of G. edulis (Gracilariales, Rhodophyta) from three different beaches along the southern part of the Special Region of Yogyakarta (Java Island, Indonesia), which has different environmental characteristics. We also observed the effect of extraction solvent on metabolomic profiling of G. edulis extract using three different solvents with the different polarity. Metabolomic profiling was performed using an LC-HRMS instrument and analyzed using the Global Natural Product Social Molecular Networking (GNPS) database. The results revealed differences in the metabolomic profiles of G. edulis’s extracts based on coastal location and solvent. G. edulis from Kukup Beach exhibited the highest metabolomic diversity (277 nodes), followed by G. edulis from Sepanjang Beach (268) and G. edulis from Krakal Beach (204). Among the solvents, n-hexane was the most effective, extracting 311 nodes, followed by methanol (293) and ethyl acetate (197). Nine tentatively dereplicated compounds were found, i.e., pumilacidine C, pumilacidine E, lichenysin, cholesterol, AC1L1X1Z, sarmentoside B, 7-dehydrocholesterol, pheophytin A and porphyra-334. Some dereplicated compounds were found in a specific area. For example, lichenysin and pumilacidin compounds were produced by G. edulis from Sepanjang Beach, while cholesterol and AC1L1X1Z were found in from G. edulis extract, which were collected from Sepanjang and Kukup Beaches, and 7-dehydrocholesterol and sarmentoside B compounds from all beach locations, while pheophytin A and porphyra-334 from Krakal Beach. Further research is needed to obtain pure compounds that have the potential to be antibacterial, as well as antioxidant, anti-inflammatory, and photoprotective compounds. Full article
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