Physical Training in Hypoxia: Physiological Changes and Performance

A special issue of Journal of Functional Morphology and Kinesiology (ISSN 2411-5142). This special issue belongs to the section "Physical Exercise for Health Promotion".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 76

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Research Group in Technology Applied to High Performance and Health, Department of Health Sciences, TecnoCampus, Universitat Pompeu Fabra, 08302 Mataró, Spain
Interests: exercise physiology; sport nutrition; trace elements; sport supplement
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Special Issue Information

Dear Colleagues,

Hypoxia training—whether conducted in natural altitude environments or under normobaric hypoxic conditions—has gained increasing attention in both sports science and clinical research due to its potential to elicit significant physiological adaptations. This Special Issue aims to provide a comprehensive overview of the latest research on the effects of physical training in hypoxia, with a focus on physiological mechanisms and performance outcomes.

Contributions to this issue will explore how hypoxic exposure influences cardiorespiratory function, hematological responses, muscular adaptations, and metabolic efficiency. Both acute and chronic adaptations are of interest, as are molecular pathways involved. Special attention will be given to training methods such as "live high–train low", intermittent hypoxic training, and hypoxic conditioning in rehabilitation or aging populations.

This Special Issue welcomes original research articles, reviews, and case studies that examine the application of hypoxic training in sport performance, health promotion, and clinical populations. Submissions addressing methodological innovations, individualized responses to hypoxia, or comparative studies between normoxic and hypoxic training environments are particularly encouraged.

Dr. Víctor Toro-Román
Guest Editor

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Keywords

  • athletes
  • oxygen
  • endurance
  • strength
  • resistance
  • fatigue

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Published Papers (1 paper)

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Research

17 pages, 1656 KiB  
Article
Acute Effect of Normobaric Hypoxia on Performance in Repeated Wingate Tests with Longer Recovery Periods and Neuromuscular Fatigue in Triathletes: Sex Differences
by Víctor Toro-Román, Pol Simón-Sánchez, Víctor Illera-Domínguez, Carla Pérez-Chirinos, Sara González-Millán, Lluís Albesa-Albiol, Sara Ledesma, Vinyet Solé, Oriol Teruel and Bruno Fernández-Valdés
J. Funct. Morphol. Kinesiol. 2025, 10(3), 282; https://doi.org/10.3390/jfmk10030282 (registering DOI) - 22 Jul 2025
Abstract
Background: Repeated high-intensity intervals under normoxic (NOR) and hypoxic (HYP) conditions is a training strategy used by athletes. Although different protocols have been used, the effect of longer recovery between repetitions is unclear. In addition, information on the effect of repeated high-intensity [...] Read more.
Background: Repeated high-intensity intervals under normoxic (NOR) and hypoxic (HYP) conditions is a training strategy used by athletes. Although different protocols have been used, the effect of longer recovery between repetitions is unclear. In addition, information on the effect of repeated high-intensity intervals on HYP in women is scarce. Aims: To analyse the differences between sexes and between conditions (NOR and HYP) in Repeated Wingate (RW) performance and neuromuscular fatigue in triathletes. Methods: A total of 12 triathletes (men: n = 7, 23.00 ± 4.04 years; women: n = 5, 20.40 ± 3.91) participated in this randomised, blinded, crossover study. In two separate sessions over seven days, participants performed 3 × 30” all out with 7′ of recovery in randomised NOR (fraction of inspired oxygen: ≈20%; ≈300 m altitude) and HYP (fraction of inspired oxygen: ≈15.5%; ≈2500 m altitude) conditions. Before and after RW, vertical jump tests were performed to assess neuromuscular fatigue. Oxygen saturation, power, perceived exertion, muscle soreness and heart rate parameters were assessed. Results: Significant differences were reported between sexes in the parameters of vertical jump, oxygen saturation, RW performance and heart rate (p < 0.05). However, between conditions (NOR and HYP), only differences in oxygen saturation were reported (p < 0.05). No significant differences were reported between conditions (NOR and HYP) in RW performance, neuromuscular fatigue, muscle soreness and perception of exertion. Conclusions: A 3 × 30” RW protocol with 7′ recovery in HYP could have no negative consequences on performance, neuromuscular fatigue and perception of exertion in triathletes compared to NOR, independently of sex. Full article
(This article belongs to the Special Issue Physical Training in Hypoxia: Physiological Changes and Performance)
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