Exercise Science and Neurodegeneration: Current Trends and Research

A special issue of Journal of Functional Morphology and Kinesiology (ISSN 2411-5142). This special issue belongs to the section "Physical Exercise for Health Promotion".

Deadline for manuscript submissions: 15 December 2026 | Viewed by 1585

Special Issue Editors


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Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
Interests: neuroanatomy; neuromorphology; molecular biology; diabetic retinopathy; neurodegenerative disease; neuropetides

E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
Interests: neuroscience; neurodegeneration; molecular biology; peptides

Special Issue Information

Dear Colleagues,

Increasing evidence supports the positive impact of exercise on human health. Exercise has been established to reduce the risk for cardiovascular disease and several other chronic diseases, including diabetes mellitus, cancer, obesity, hypertension, bone and joint diseases, and neurodegenerative disease.

Although the exact mechanisms by which this occurs remain unclear, growing research points to exercise’s neuroprotective effects in both human and animal models, with a particular focus on mental health, neurodegenerative conditions, and brain injuries. This Special Issue aims to explore the relationship between exercise and brain function in physiological and/or pathological conditions using clinical and animal studies. Original articles and review articles are welcome.

Dr. Grazia Maugeri
Prof. Dr. Velia D'Agata
Guest Editors

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Keywords

  • exercise
  • neuroprotection
  • neurodegenerative diseases
  • Alzheimer’s disease
  • Parkinson’s disease
  • amyotrophic lateral sclerosis

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Published Papers (1 paper)

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Research

15 pages, 16027 KB  
Article
Moderate Exercise Stimulates PACAP-Mediated Neurogenesis in Rat Dentate Gyrus and Cerebellar Cortex
by Grazia Maugeri, Salvatore Di Bartolo, Nicoletta Palmeri, Agata Grazia D’Amico, Desiree Brancato, Concetta Federico, Velia D’Agata and Giuseppe Musumeci
J. Funct. Morphol. Kinesiol. 2026, 11(1), 37; https://doi.org/10.3390/jfmk11010037 - 15 Jan 2026
Cited by 1 | Viewed by 1108
Abstract
Background: Moderate physical activity (PA) exerts powerful systemic and neuroprotective effects, reducing chronic disease risk and enhancing cognitive and psychological well-being. PA promotes brain plasticity by upregulating neurotrophic factors and stimulating neurogenesis. Given the established role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in [...] Read more.
Background: Moderate physical activity (PA) exerts powerful systemic and neuroprotective effects, reducing chronic disease risk and enhancing cognitive and psychological well-being. PA promotes brain plasticity by upregulating neurotrophic factors and stimulating neurogenesis. Given the established role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in neuronal survival, differentiation, and anti-apoptotic signaling, we aimed to investigate whether moderate PA modulates the endogenous expression of PACAP and its specific receptor PAC1R in the DG and cerebellar cortex. Methods: To this end, twenty-four rats were distributed into sedentary or exercise groups. Immunohistochemical and Western blot analyses were performed to assess PACAP and PAC1R expression. Co-expression with doublecortin (DCX), a marker of immature neurons, was evaluated to explore the direct relationship between PACAP signaling and neurogenesis. Results: Our results showed that moderate PA induced a significant up-regulation of PACAP and PAC1R in both the DG and cerebellar cortex compared to sedentary controls. Moreover, high co-expression of PACAP and DCX was detected in these regions, suggesting an involvement of PACAP in exercise-induced neurogenic processes. Conclusions: These findings demonstrate that moderate physical activity is associated with enhanced PACAP/PAC1R signaling and DCX expression in neurogenic regions, warranting further investigation into its specific contribution to exercise-induced brain plasticity. Full article
(This article belongs to the Special Issue Exercise Science and Neurodegeneration: Current Trends and Research)
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