Biomaterials for Hemostasis and Wound Healing Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 842

Special Issue Editors


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Guest Editor
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Interests: biomaterials; hemostasis; thrombosis; bioadhesives; hydrogels; polymer chemistry; living materials; cell surface engineering

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Guest Editor
Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: polymeric biomaterials; interface chemistry; bioadhesives; polyphenol

Special Issue Information

Dear Colleagues,

Effective control of bleeding and promotion of wound healing remain critical challenges in trauma care, surgery, military medicine, and chronic wound management. This Special Issue highlights recent advances in biomaterials developed for hemostasis and wound healing, spanning fundamental research, translational technologies, and clinical applications. We invite contributions to the design and characterization of hemostatic agents, wound dressings, tissue adhesives, bioactive scaffolds, and multifunctional materials with antimicrobial or immunomodulatory properties, etc.

This issue is situated within a rapidly evolving field where material design intersects with cellular biology, biomechanics, bioelectronics, and regenerative medicine. While traditional wound care materials are well studied, emerging technologies that actively modulate coagulation, immune responses, and healing—or integrate real-time sensing, modeling, and therapeutic delivery—represent a new frontier. We aim to showcase interdisciplinary innovations that address unmet clinical needs in acute and chronic wounds, surgical bleeding, and battlefield injuries.

Original research articles, comprehensive reviews, and perspectives are encouraged. We look forward to your contributions to this exciting and impactful topic.

Dr. Shuaibing Jiang
Dr. Jingxian Wu
Guest Editors

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Keywords

  • biomaterials
  • hemostasis
  • hemorrhage
  • wound healing
  • tissue repair
  • tissue regeneration

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Published Papers (1 paper)

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16 pages, 857 KB  
Systematic Review
Application of Advanced Platelet-Rich Fibrin Plus in Oral Wound Healing and Pain Management: A Systematic Literature Review
by Marek Chmielewski, Andrea Pilloni and Paulina Adamska
J. Funct. Biomater. 2025, 16(10), 360; https://doi.org/10.3390/jfb16100360 - 26 Sep 2025
Viewed by 701
Abstract
Background: The growing interest in the field of platelet-rich fibrins has led to the development of novel generations of these concentrates, with one of the newest additions being advanced platelet-rich fibrin plus (A-PRF+). The updated centrifuge protocol utilized for the preparation of A-PRF+ [...] Read more.
Background: The growing interest in the field of platelet-rich fibrins has led to the development of novel generations of these concentrates, with one of the newest additions being advanced platelet-rich fibrin plus (A-PRF+). The updated centrifuge protocol utilized for the preparation of A-PRF+ has been shown to provide blood clots with more white blood cells and growth factors trapped in the fibrin matrix, presenting a more homogenous distribution. The objective of this study was to assess the available randomized clinical trials (RCTs), in order to evaluate the effects that the addition of A-PRF+ can have on postoperative quality of life and soft tissue healing after dental surgery. Materials and Methods: To perform a systematic review based on high-quality results, only RCTs were taken into consideration. The search included articles published between 1 January 2014 and 31 December 2024, indexed in the PubMed, Cochrane, Library, Embase, Scopus, and Google Scholar databases. Nine full texts were finally acquired after the screening of articles, from which relevant data were extracted. Results: A-PRF+ positively influenced the postoperative quality of life in patients. The subjective analysis of pain and its management via painkiller intake indicated that, in general, the addition of A-PRF+ into protocols results in less pain, pain that lasts for a shorter time, and pain that is more easily managed through medication, as a lower number of pills was needed to restore comfort. Furthermore, the occurrence of facial swelling and trismus was also reported to be lower in the A-PRF+ groups. As for soft tissue healing, A-PRF+ significantly enhanced the epithelialization process, total wound area reduction, and inflammation in the surrounding tissues. This positive effect was most noticeable at 7- and 14-day follow-ups. The addition of A-PRF+ also had a positive effect on postoperative bleeding by significantly reducing the bleeding time, providing benefits for patients undergoing antiplatelet drug therapy in particular. Conclusions: The addition of A-PRF+ into the surgical protocol can positively enhance the patient’s quality of life, reduce the need for postoperative medication, and improve the patient’s confidence by reducing potential swelling and trismus. A-PRF+ also positively influences soft tissue wound healing, further enhancing the postoperative well-being of patients, and provides an excellent hemostatic effect even in patients that are on antiplatelet drug therapy. Full article
(This article belongs to the Special Issue Biomaterials for Hemostasis and Wound Healing Applications)
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