Application of Biomaterials in Tissue Engineering and Regenerative Medicine—2nd Edition

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1033

Special Issue Editor

Special Issue Information

Dear Colleagues,

Regenerative medicine is a field that aims to enhance the body's natural healing abilities using advanced medical technologies, and tissue engineering is at the core of this field, which relies heavily on biomaterials with transformative potential. These biocompatible substances not only provide a structural foundation for engineered tissues, but also guide cellular responses, deliver therapeutic agents, and assimilate with host tissues. Recent advancements have enabled the successful regeneration of complex structures like vasculature, which previously relied on evolving biomaterial properties. This Special Issue explores the intricate relationship between tissue regeneration and biomaterials, discussing advancements in both hard and soft tissue reconstruction, novel scaffold designs, and bioactive compound integration. The use of biomaterials has significantly expanded the horizons of regenerative medicine, providing new avenues for research and development. I look forward to your participation in this Special Issue, as we work towards uncovering the full potential of biomaterials in regenerative medicine.

Dr. Carlos Fernando Mourão
Guest Editor

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Keywords

  • biomaterials
  • tissue engineering
  • regenerative medicine
  • bone regeneration
  • soft tissue regeneration

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Published Papers (1 paper)

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Research

26 pages, 4906 KB  
Article
A Borophosphate Glass Doped with Cobalt Oxide Improves Skeletal Muscle Structure and Function in Myopathic Mice
by Jacob A. Kendra, Alexandra G. Naman, Rebekah L. Blatt, Carla D. Zingariello, Richard K. Brow, Steven S. Segal and Aaron B. Morton
J. Funct. Biomater. 2026, 17(3), 155; https://doi.org/10.3390/jfb17030155 - 20 Mar 2026
Viewed by 799
Abstract
Skeletal muscle myopathy remains a significant cause of disability with limited treatment strategies. Advancements in tissue engineering have led to the development of borophosphate bioactive glasses (BPBGs) capable of enhancing skeletal muscle structure and function. Using a mouse model of severe myopathy (D2. [...] Read more.
Skeletal muscle myopathy remains a significant cause of disability with limited treatment strategies. Advancements in tissue engineering have led to the development of borophosphate bioactive glasses (BPBGs) capable of enhancing skeletal muscle structure and function. Using a mouse model of severe myopathy (D2.mdx), we investigated muscle force, regeneration, angiogenesis and inflammation at 14, 70 and 140 days post-treatment (dpt). Tibialis anterior (TA) muscles of D2.mdx mice that received a single injection of cobalt oxide-doped BPBG (CoO-TRIM) particles exhibit greater active force, myofiber size, and regeneration through 70 dpt compared to control D2.mdx mice injected with Saline. Vascular endothelial growth factor (VEGF) was elevated up to 70 dpt in D2.mdx CoO-TRIM mice followed by increased muscle vascularity. As a marker of inflammation, interleukin (IL)-6 increased in D2.mdx CoO-TRIM mice compared to D2.mdx Saline controls at 14 dpt, with no differences at 70 or 140 dpt. No differences were observed in outcome measures between wild-type (WT) CoO-TRIM mice and WT Saline controls. We report that CoO-TRIM can stimulate VEGF production and promote restoration of muscle structure and function when inflammation is present. Local injection of an inorganic biomaterial alone can benefit myopathic skeletal muscle. Full article
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