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Biomimetic Biomaterials-Based Scaffolds for Tissue Engineering

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A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 7686

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Special Issue Editor

Dr. Sylvie Ribeiro

E-Mail Website
Guest Editor

1. Centre of Physics, University of Minho, 4710-058 Braga, Portugal
2. IB-S—Institute for Research and Innovation on Bio-Sustainability, University of Minho, 4710-057 Braga, Portugal
Interests: tissue engineering; smart materials; biomaterials; cell-matrix interactions; cell microenvironment

Special Issue Information

Dear Colleagues,

The aim of this Special Issue, “Biomimetic Biomaterials-Based Scaffolds for Tissue Engineering”, is to cover a variety of recent research trends in the field of biomaterials, tissue engineering and regeneration approaches. Reviews on specific topics within this field will also be accepted.

Mimicking the microenvironment present in cells represents a needed approach to obtain effective strategies for tissue engineering. In this sense, the field of tissue engineering is advancing rapidly, and many of these advances would not be possible without the design and development of innovative biomaterials as a way of responding most closely in the mimicry of the organs or tissues present in human body. In this way, for better and more efficient TE approaches, biomaterials design must take into consideration the mechanobiological and electrobiological niche of each tissue. The Special Issue will consider the main types of biomaterials, both synthetic and natural, that are able to provide specific stimuli to the cell culture. Experimental techniques to obtain such materials in different forms and shapes will be also welcomed, as well as the evaluation of cell–biomaterial scaffold interactions and cell responses. Biomaterials reinforced with (nano)materials in order to achieve multifunctional smart materials will be also considered.

Dr. Sylvie Ribeiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

regenerative medicine
tissue engineering
tissues and organs
biomaterials
3D biomimetic scaffolds
cell-biomaterial interface

Published Papers (3 papers)

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Research

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15 pages, 3580 KiB

Open AccessArticle

Preparation and Characterization of Extracellular Matrix Hydrogels Derived from Acellular Cartilage Tissue

by Tsong-Hann Yu, Tsu-Te Yeh, Chen-Ying Su, Ni-Yin Yu, I-Cheng Chen and Hsu-Wei Fang

J. Funct. Biomater. 2022, 13(4), 279; https://doi.org/10.3390/jfb13040279 - 7 Dec 2022

Cited by 3 | Viewed by 2444

Abstract

Decellularized matrices can effectively reduce severe immune rejection with their cells and eliminated nucleic acid material and provide specific environments for tissue repair or tissue regeneration. In this study, we prepared acellular cartilage matrix (ACM) powder through the decellularization method and developed ACM hydrogels by physical, chemical, and enzymatic digestion methods. The results demonstrated that the small size group of ACM hydrogels exhibited better gel conditions when the concentration of ACM hydrogels was 30 and 20 mg/mL in 1N HCl through parameter adjustment. The data also confirmed that the ACM hydrogels retained the main components of cartilage: 61.18% of glycosaminoglycan (GAG) and 78.29% of collagen, with 99.61% of its DNA removed compared to samples without the decellularization procedure (set as 100%). Through turbidimetric gelation kinetics, hydrogel rheological property analysis, and hydrogel tissue physical property testing, this study also revealed that increasing hydrogel concentration is helpful for gelation. Besides, the ex vivo test confirmed that a higher concentration of ACM hydrogels had good adhesive properties and could fill in cartilage defects adequately. This study offers useful information for developing and manufacturing ACM hydrogels to serve as potential alternative scaffolds for future cartilage defect treatment. Full article

(This article belongs to the Special Issue Biomimetic Biomaterials-Based Scaffolds for Tissue Engineering)

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19 pages, 4391 KiB

Open AccessEditor’s ChoiceArticle

3D-Braided Poly-ε-Caprolactone-Based Scaffolds for Ligament Tissue Engineering

by Caroline Emonts, David Wienen, Benedict Bauer, Akram Idrissi and Thomas Gries

J. Funct. Biomater. 2022, 13(4), 230; https://doi.org/10.3390/jfb13040230 - 8 Nov 2022

Cited by 1 | Viewed by 1926

Abstract

The anterior cruciate ligament (ACL) is the most commonly injured intra-articular ligament of the knee. Due to its limited intrinsical healing potential and vascularization, injuries of the ACL do not heal satisfactorily, and surgical intervention is usually required. The limitations of existing reconstructive grafts and autologous transplants have prompted interest in tissue-engineered solutions. A tissue engineering scaffold for ACL reconstruction must be able to mimic the mechanical properties of the native ligament, provide sufficient porosity to promote cell growth of the neoligament tissue, and be biodegradable. This study investigates long-term biodegradable poly-ε-caprolactone (PCL)-based scaffolds for ACL replacement using the 3D hexagonal braiding technique. The scaffolds were characterized mechanically as well as morphologically. All scaffolds, regardless of their braid geometry, achieved the maximum tensile load of the native ACL. The diameter of all scaffolds was lower than that of the native ligament, making the scaffolds implantable with established surgical methods. The 3D hexagonal braiding technique offers a high degree of geometrical freedom and, thus, the possibility to develop novel scaffold architectures. Based on the findings of this study, the 3D-braided PCL-based scaffolds studied were found to be a promising construct for tissue engineering of the anterior cruciate ligament. Full article

(This article belongs to the Special Issue Biomimetic Biomaterials-Based Scaffolds for Tissue Engineering)

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Review

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30 pages, 2351 KiB

Open AccessReview

Revolutionizing the Use of Honeybee Products in Healthcare: A Focused Review on Using Bee Pollen as a Potential Adjunct Material for Biomaterial Functionalization

by Arka Sanyal, Anushikha Ghosh, Chandrashish Roy, Ishanee Mazumder and Pasquale Marrazzo

J. Funct. Biomater. 2023, 14(7), 352; https://doi.org/10.3390/jfb14070352 - 4 Jul 2023

Cited by 3 | Viewed by 2768

Abstract

The field of biomedical engineering highly demands technological improvements to allow the successful engraftment of biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, particularly natural polymers, are one of the primary suitable materials employed and functionalized to enhance their biocompatibility and thus confer advantageous features after graft implantation. Incorporating bioactive substances from nature is a good technique for expanding or increasing the functionality of biomaterial scaffolds, which may additionally encourage tissue healing. Our ecosystem provides natural resources, like honeybee products, comprising a rich blend of phytochemicals with interesting bioactive properties, which, when functionally coupled with biomedical biomaterials, result in the biomaterial exhibiting anti-inflammatory, antimicrobial, and antioxidant effects. Bee pollen is a sustainable product recently discovered as a new functionalizing agent for biomaterials. This review aims to articulate the general idea of using honeybee products for biomaterial engineering, mainly focusing on describing recent literature on experimental studies on biomaterials functionalized with bee pollen. We have also described the underlying mechanism of the bioactive attributes of bee pollen and shared our perspective on how future biomedical research will benefit from the fabrication of such functionalized biomaterials. Full article

(This article belongs to the Special Issue Biomimetic Biomaterials-Based Scaffolds for Tissue Engineering)

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