Studies on Implantable Scaffolds: Designs and Biomechanical Properties

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 2265

Special Issue Editor


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Guest Editor
School of Biomedical Engineering, University of Technology Sydney, Sydney, Australia
Interests: biomechanics; tissue engineering; computational mechanics; additive manufacturing; medical device development

Special Issue Information

Dear Colleagues,

Tissue engineering is an interdisciplinary discipline at the intersection of materials science, engineering, and biology to regenerate various types of biological tissues. Advances in scaffold-based tissue engineering continue in response to the growing need for tissue replacement caused by diseases, trauma, or cancers. Despite the explosion of work on the development of synthetic tissue scaffolds, remarkably few have been translated to the clinic. A significant obstacle to translation is that existing scaffolds lack adequate mechanical properties while maintaining biological complexities.

This Special Issue encourages researchers to present their studies concerning the improvement in the biomechanical properties of synthetic tissue scaffolds through innovative approaches in materials science, structural design, or in silico methods.

It is our pleasure to invite all of you to submit your research to this Special Issue. Research Articles, Communications, and Review Papers are welcome!

Dr. Ali Entezari
Guest Editor

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Keywords

  • tissue engineering
  • tissue scaffolds
  • numerical modeling
  • biomaterials
  • scaffold design
  • structural optimization

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Published Papers (1 paper)

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Research

17 pages, 26346 KiB  
Article
On the Biomechanical Performances of Duplex Stainless Steel Graded Scaffolds Produced by Laser Powder Bed Fusion for Tissue Engineering Applications
by Maria Laura Gatto, Giorgia Cerqueni, Riccardo Groppo, Emanuele Tognoli, Alberto Santoni, Marcello Cabibbo, Monica Mattioli-Belmonte and Paolo Mengucci
J. Funct. Biomater. 2023, 14(10), 489; https://doi.org/10.3390/jfb14100489 - 22 Sep 2023
Cited by 3 | Viewed by 1800
Abstract
This experimental study aims to extend the know-how on biomechanical performances of duplex stainless steel (DSS) for tissue engineering applications to a graded lattice geometry scaffold based on the F53 DSS (UNS S32750 according to ASTM A182) produced by laser powder bed fusion [...] Read more.
This experimental study aims to extend the know-how on biomechanical performances of duplex stainless steel (DSS) for tissue engineering applications to a graded lattice geometry scaffold based on the F53 DSS (UNS S32750 according to ASTM A182) produced by laser powder bed fusion (LPBF). The same dense-out graded geometry based on rhombic dodecahedral elementary unit cells investigated in previous work on 316L stainless steel (SS) was adopted here for the manufacturing of the F53 DSS scaffold (SF53). Microstructural characterization and mechanical and biological tests were carried out on the SF53 scaffold, using the in vitro behavior of the 316L stainless steel scaffold (S316L) as a control. Results show that microstructure developed as a consequence of different volume energy density (VED) values is mainly responsible for the different mechanical behaviors of SF53 and S316L, both fabricated using the same LPBF manufacturing system. Specifically, the ultimate compressive strength (σUC) and elastic moduli (E) of SF53 are three times and seven times higher than S316L, respectively. Moreover, preliminary biological tests evidenced better cell viability in SF53 than in S316L already after seven days of culture, suggesting SF53 with dense-out graded geometry as a viable alternative to 316L SS for bone tissue engineering applications. Full article
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