Advanced Materials for Clinical Endodontic Applications (3rd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 3519

Special Issue Editors


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Institute of Dentistry, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania
Interests: engine-driven root canal instruments; root canal filling materials; hydraulic calcium silicate cement
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Guest Editor
Department of Paediatric Dentistry, Ghent University School of Oral Health Sciences, B-9000 Ghent, Belgium
Interests: dental; silicate cement; Medline; endodontics dentistry; pediatric dentistry
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Department of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, D-93093 Regensburg, Germany
Interests: pulp biology; tissue engineering; dentin matrix proteins; dental pulp stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our great pleasure to invite you to contribute to the Special Issue titled “Advanced Materials for Clinical Endodontic Applications (3rd Edition)”. Over the past decades, endodontics has undergone a rapid evolution driven by the introduction of novel instruments, biomaterials, and innovative treatment concepts. Beyond the traditional goals of root canal disinfection and sealing, new materials and application strategies now allow clinicians to pursue more biologically based, minimally invasive, and patient-oriented approaches.

This Special Issue of the Journal of Functional Biomaterials will cover a broad range of state-of-the-art topics in endodontic biomaterials science and clinical translation, including, but not limited to, the following:

  • Novel materials: advanced bioceramics, resin-based and hybrid systems, functional nanomaterials, bioactive composites, and injectable scaffolds.
  • Material applications: irrigation/disinfection solutions, intracanal medicaments, temporary and permanent sealing materials, vital pulp therapy capping agents, apexification, and root canal filling systems.
  • Clinical integration: guided and dynamic navigation in endodontics, minimally invasive access designs, and biomaterials for the management of calcified canals and iatrogenic complications.
  • Regenerative endodontics: scaffolds, growth factor delivery systems, stem cell-supportive matrices, and bioactive interfaces that promote dentin–pulp complex regeneration.
  • Endodontic surgery and repair materials: sealing, bone and periodontal interface regeneration, and biomaterials for apical microsurgery.
  • Novel evaluation techniques: characterization of physical, chemical, biological, and antibacterial properties of newly developed biomaterials.

This Special Issue will accept and publish high-quality original articles, reviews, and short communications covering the full spectrum from in vitro and in vivo studies to clinical applications. Contributions are welcome from biomaterial scientists, engineers, and clinicians aiming to highlight both the fundamental properties of novel materials and techniques and their translation into everyday endodontic practice.

We look forward to receiving your contributions to advance knowledge and innovation in the field of clinical endodontics and functional biomaterials.

Prof. Dr. Saulius Drukteinis
Prof. Dr. Sivaprakash Rajasekharan
Prof. Dr. Matthias Widbiller
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • bioceramics
  • resin-based materials
  • nanomaterials
  • bioactive composites
  • endodontic sealers
  • irrigation solutions
  • intracanal medicaments
  • apexification
  • pulp capping
  • guided endodontics
  • regenerative endodontics
  • scaffolds
  • functional biomaterials
  • endodontic surgery
  • vital pulp therapy
  • pediatric endodontic biomaterials
  • dynamic navigation
  • antibacterial properties
  • biomaterial–tissue interactions

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13 pages, 1080 KB  
Article
Accuracy of Dynamic Navigation vs. Freehand Endodontic Access Cavity Preparation in 3-Dimensionally Printed Teeth with Severe Pulp Canal Calcification
by Egle Marija Urbone, Paulius Tusas, Ieva Gendviliene, Vygandas Rutkunas and Saulius Drukteinis
J. Funct. Biomater. 2025, 16(10), 376; https://doi.org/10.3390/jfb16100376 - 9 Oct 2025
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Abstract
Background: Pulp canal calcification (PCC) poses a challenge for endodontic treatment, as it obscures the canal and increases the risk of complications. This study aimed to evaluate the accuracy of endodontic access cavity preparation using dynamic navigation (DN) and to compare it with [...] Read more.
Background: Pulp canal calcification (PCC) poses a challenge for endodontic treatment, as it obscures the canal and increases the risk of complications. This study aimed to evaluate the accuracy of endodontic access cavity preparation using dynamic navigation (DN) and to compare it with the freehand (FH) technique in teeth with severe PCC. Materials and Methods: Sixty 3D printed maxillary central incisors with simulated severe PCC were divided into two groups and accessed either with a DN system or by the conventional FH technique. Accuracy was evaluated by comparing planned and performed access cavity trajectories on preoperative and postoperative CBCT scans. Preparation time and procedural errors were recorded. Normality was assessed with the Shapiro–Wilk test. The Mann–Whitney U test was used to compare continuous variables. The significance level was set at 0.05. Results: The DN group showed significantly lower apical point 3D deviation (1.25 vs. 1.96 mm, p = 0.001), apical point depth deviation (0.43 vs. 0.88 mm, p < 0.001), and angular deflection (1.93 vs. 5.71 degrees, p < 0.001) than the FH group. The DN group had fewer procedural errors. The endodontic access entry point deviation was comparable between both techniques (p = 0.395). The preparation time was significantly higher in the DN group (204 vs. 108.5 s, p < 0.001). Conclusions: DN significantly improves the accuracy of access cavity preparation in calcified canals compared to the FH approach, reducing the risk of complications. Therefore, DN can be a valuable tool for managing challenging endodontic cases. As guided endodontic access preparation can be more time-consuming, extended treatment appointments may be required. Full article
(This article belongs to the Special Issue Advanced Materials for Clinical Endodontic Applications (3rd Edition))
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