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Magnetic Materials for Medical Use
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Magnetic Materials for Medical Use

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1509

Special Issue Editor

Dr. Sorina Dinescu

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania
Interests: non-coding RNAs; transcriptomics; chromatin conformation; extracellular vesicles; exosomes; human adipose-derived stem cells; stemm cell differentiation; neurogenesis; adipogenesis; osteogenesis; tissue engineering; biocompatibility; biomaterials; magnetic nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Magnetic materials and magnetic stimulation have gained increasing attention for medical applications, particularly for tissue engineering (TE) and reconstruction. Magnetism can be used to modulate cell fate, direct cell responses to environmental factors, or commit stem cells to certain lineages. Magnetic fields and nanoparticles (MNPs) may trigger complex molecular mechanisms such as focal adhesion changes, further translating into the reorganization of the cytoskeleton architecture, activation of mechanotransduction pathways, modulation of the epigenetic profile, and chromatin changes.

In the medical field, magnetic materials including MNPs are extensively used in magnetic resonance imaging, drug delivery, bones, and dentistry, as well as other magnetic therapy applications. This Special Issue welcomes contributions in the form of original articles, reviews, and short communications, all related to the benefits of using magnetic materials for biomedical applications. We expect submitted manuscripts to address topics including (but not limited to) the following:

  • MNPs and magnetic materials for regenerative therapies;
  • Modulation of signalling pathways with the aid of MNPs and magnetic stimulation for therapeutic purposes;
  • MNPs as tools to improve diagnostic and targeted therapy;
  • MNPs as delivery vehicles for biomedical applications.

Dr. Sorina Dinescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • magnetism
  • magnonics
  • tissue engineering
  • regenerative medicine
  • electromagnetic field
  • magnetic actuation
  • cell signalling

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 6890 KiB  
Article
Synthesis of ε-Fe2–3N Particles for Magnetic Hyperthermia
by Soichiro Usuki, Tomoyuki Ogawa, Masaya Shimabukuro, Taishi Yokoi and Masakazu Kawashita
J. Funct. Biomater. 2025, 16(6), 203; https://doi.org/10.3390/jfb16060203 - 1 Jun 2025
Viewed by 566
Abstract
Little research has focused on using iron nitride as thermoseed particles in magnetic hyperthermia, although magnetite (Fe3O4) is commonly used for this purpose. In the present study, we focus on iron nitride, especially ε-Fe2–3N. ε-Fe2–3N [...] Read more.
Little research has focused on using iron nitride as thermoseed particles in magnetic hyperthermia, although magnetite (Fe3O4) is commonly used for this purpose. In the present study, we focus on iron nitride, especially ε-Fe2–3N. ε-Fe2–3N particles were synthesized from hematite (α-Fe2O3) and sodium amide (NaNH2) under various synthesis conditions, and the heat-generation properties of the particles were investigated to reveal the synthesis conditions that lead to particles with notable heat-generation performance. The particles synthesized at 250 °C for 12 h increased the temperature of an agar phantom by approximately 20 °C under an alternating magnetic field (100 kHz, 125 Oe, 600 s), suggesting that ε-Fe2–3N particles can be used for magnetic hyperthermia. The analysis results for the particles synthesized under different conditions suggest that the heat-generation properties of ε-Fe2–3N were affected by several factors, including the nitrogen content, particle size, crystallite size, saturation magnetization, and coercive force. Full article
(This article belongs to the Special Issue Magnetic Materials for Medical Use)
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14 pages, 874 KiB  
Article
Diagnostic Value of Superparamagnetic Iron Oxide Nanoparticles as a Tracer for Sentinel Lymph Node Mapping in Early-Stage Cervical Cancer: The Preliminary Clinical Experience
by Marcin A. Jedryka, Andrzej Czekanski, Marcin Kryszpin, Tymoteusz Poprawski, Krzysztof Grobelak, Piotr Lepka and Rafał Matkowski
J. Funct. Biomater. 2025, 16(6), 196; https://doi.org/10.3390/jfb16060196 - 26 May 2025
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Abstract
Sentinel lymph node (SLN) mapping has been investigated as part of surgical staging in women with early-stage cervical cancer (CC); however, pelvic lymphadenectomy (PLND) remains the standard of care. This study aimed to assess feasibility and safety of SLN detection using superparamagnetic iron [...] Read more.
Sentinel lymph node (SLN) mapping has been investigated as part of surgical staging in women with early-stage cervical cancer (CC); however, pelvic lymphadenectomy (PLND) remains the standard of care. This study aimed to assess feasibility and safety of SLN detection using superparamagnetic iron oxide (SPIO) nanoparticles as a tracer in CC. Thirty CC patients presumed to be stage I were included in this study with SPIO administered intracervically as a tracer for SLN mapping using a magnetometer and followed by PLND. The endpoints of the study included the proportion of successful SLN detection, the average number of SLNs per patient, and the proportion of pathologically positive results per patient and per node. The diagnostic accuracy of SPIO nanoparticles for detection of metastatic SLNs was evaluated by Receiver Operating Characteristic (ROC) curve analysis, with the area under the ROC curve (AUC) used to demonstrate the studied method’s sensitivity. Safety endpoints were a summary of all reported adverse events. SLNs were detected in all cases, bilaterally in 27 patients (90%). The median number of SLNs per patient was 3.5. Four cases had metastatic SLNs. The general malignancy rate per patient was 13.3%, and per node, it was 0.8%. The malignancy detection rate of SLNs was 100% per patient and 80% per node. The AUC of 1.0 (p < 0.001) confirmed the diagnostic value of the SPIO technique for the detection of metastatic SLNs, with a sensitivity of 100%. No adverse events related to the SPIO administration were reported. SPIO nanoparticles, as a tracer for SLN mapping in early-stage CC patients, demonstrated satisfactory accuracy parameters and safety; however, these data need to be evaluated by further research. Full article
(This article belongs to the Special Issue Magnetic Materials for Medical Use)
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