Functional Natural, Hybrid and Bioinspired Biomaterials for Biomedical Applications

Special Issue Editors


E-Mail Website
Guest Editor
Civil and Environmental Engineering, South Dakota School of Mines, 501 E. St. Joseph Street, Rapid City, SD 57701, USA
Interests: functional biomaterials; wound healing; nanocomposites; natural polymer-based delivery systems
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Facultad de Ingeniería y Tecnología, Universidad San Sebastián, Sede Concepción, Chile
Interests: nanobiomaterials; biocidal materials; hydrogels; infection control; nanomedicine; 3D- and 4D-printed biomaterials; packaging materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural and bioinspired materials have emerged as transformative platforms for developing next-generation biomaterials with tunable physicochemical and biological properties. This Special Issue will highlight recent advances in the design, synthesis, characterization, and biomedical applications of functional natural, hybrid, and bioinspired biomaterials for wound healing, tissue regeneration and drug delivery. Particular attention will be paid to naturally derived polymers (such as chitosan, silk fibroin, collagen, gelatin, alginate, and hyaluronic acid, among others) and their hybrid systems with synthetic polymers, nanoparticles, or lipid-based carriers. Topics of interest include novel biofabrication methods, chemical and physical modification techniques, and multifunctional designs that enhance biocompatibility, antibacterial activity, and controlled release performance. Studies focusing on mechanistic insights, structure–function relationships, and translational potential in regenerative medicine and therapeutic delivery are especially encouraged. Both original research articles and comprehensive reviews are welcome.

Dr. Tippabattini Jayaramudu
Dr. Varaprasad Kokkarachedu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural biomaterials
  • bio-based polymeric materials
  • hybrid biomaterials
  • bioinspired materials: design of biomimetic polymer-based devices
  • bio-based polymeric materials
  • biodegradability of polymeric materials
  • tissue regeneration
  • drug delivery systems
  • functional polymers
  • nanocomposites
  • regenerative medicine
  • wound healing
  • three- and four-dimensional biomaterials

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 3942 KB  
Article
Preparation of Uniform PEG-PLLA Microspheres via Membrane Emulsification for Soft Tissue Filling Applications
by Siqi Zhang, Yuan Gao, Danyang Wang, Yongjie Chi, Fang Wu, Lianyan Wang and Hailan Jin
J. Funct. Biomater. 2026, 17(2), 71; https://doi.org/10.3390/jfb17020071 - 30 Jan 2026
Abstract
Skin aging could lead to dermal collagen loss and elastic fiber degradation, ultimately manifesting as skin laxity. We aimed to counteract this by using poly-L-lactic acid (PLLA) microsphere (MS)-based fillers to facilitate long-term volume restoration through collagen regeneration. However, conventional MSs exhibit limitations [...] Read more.
Skin aging could lead to dermal collagen loss and elastic fiber degradation, ultimately manifesting as skin laxity. We aimed to counteract this by using poly-L-lactic acid (PLLA) microsphere (MS)-based fillers to facilitate long-term volume restoration through collagen regeneration. However, conventional MSs exhibit limitations such as broad size distribution and surface irregularities, which are frequently associated with significant adverse reactions. This study employed shirasu porous glass (SPG) membrane emulsification to fabricate uniform and well-shaped polyethylene glycol-block-poly (L-lactic acid) (PEG-PLLA) MSs. A single-factor experiment was employed to optimize the parameters. The optimal preparation conditions for PEG-PLLA MSs were as follows: PEG-PLLA concentration of 40 mg/mL, polyvinyl alcohol (PVA) concentration of 0.5%, and magnetic stirring speed of 200 rpm. Under the optimal conditions, the average particle size of PEG-PLLA MSs was 58.982 μm, and the span value (SPAN) was 1.367. In addition, a cytotoxicity assay was performed, and the results revealed no significant toxicity of the MSs toward L929 mouse fibroblasts at concentrations below 500 μg/mL. Furthermore, PEG-PLLA MSs significantly enhanced the production of key extracellular matrix (ECM) components—type I collagen (Col-I), type III collagen (Col-III), and hyaluronic acid (HA)—while simultaneously alleviating cellular oxidative stress responses. This work offers a reliable and reproducible fabrication strategy for developing biocompatible MS fillers with controllable particle sizes. Full article
Show Figures

Figure 1

Back to TopTop