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Advances in Biomaterials for Oral Health: From Dental Restoration to...
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Advances in Biomaterials for Oral Health: From Dental Restoration to Regenerative Therapies

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 May 2027 | Viewed by 1707

Special Issue Editors

Dr. Diana Marian

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Guest Editor
Department of Dentistry, Faculty of Dentistry, “Vasile Goldiș” Western University of Arad, Arad, Romania
Interests: oral health; dental biomaterials; preventive dentistry; endodontics; bioactive materials
Special Issues, Collections and Topics in MDPI journals
Dr. Ioana Elena Lile

E-Mail Website
Guest Editor
Department of Dentistry, Faculty of Dentistry, “Vasile Goldiș” Western University of Arad, Arad, Romania
Interests: oral health; oral hygiene; dental biomaterials; preventive dentistry; bioactive materials
Special Issues, Collections and Topics in MDPI journals
Dr. Ramona A. Popovici

E-Mail Website
Guest Editor
Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timișoara, 300041 Timișoara, Romania
Interests: dental medicine; oral health education; health management; dental praxis

Special Issue Information

Dear Colleagues,

In recent years, advances in dental science have led to the emergence of innovative biomaterials that not only restore but also regenerate oral tissues, bridging the gap between restorative and regenerative dentistry.

Contemporary biomaterials in restorative dentistry adapt dynamically to mechanical stress, pH, and temperature changes, integrating both diagnostic and therapeutic functions into clinical applications. Examples include nanocomposites, hydrogels, bioactive agents, resin-based systems, ceramics, and intelligent carrier platforms.

Regenerative dentistry, on the other hand, substitutes physiologically functional tissues for damaged ones, such as the tooth structure, alveolar bone, periodontal ligament, and dental pulp. Biomaterials that support and direct tissue regeneration are becoming essential tools in clinical practice. Their biocompatibility and immunomodulatory properties are fundamental to the development of personalized, regenerative oral treatments.

This Special Issue, “Advances in Biomaterials for Oral Health: From Dental Restoration to Regenerative Therapies”, brings together original research articles and comprehensive reviews that explore the latest developments in biomaterials applied to oral health.

Dr. Diana Marian
Dr. Ioana Elena Lile
Dr. Ramona A. Popovici
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • nanocomposites
  • nanoactive particles
  • bioactive agents
  • tissue regeneration
  • hydrogels
  • scaffold
  • bone regeneration
  • biocompatibility
  • extracellular matrix

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Published Papers (1 paper)

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Review

22 pages, 780 KB  
Review
Antibacterial and Bioregenerative Nanomaterials in Oral Health: From Material Design to Clinical Translation and Technological Trends
by Dana Emanuela Pitic (Cot), Aniela-Roxana Nodiți-Cuc, Cristina Ioana Talpos-Niculescu, Diana Marian, Ramona Amina Popovici, Andreea Mihaela Kis, Laria-Maria Trusculescu, Adina Feher and Ioana Elena Lile
J. Funct. Biomater. 2026, 17(2), 87; https://doi.org/10.3390/jfb17020087 - 10 Feb 2026
Cited by 2 | Viewed by 1176
Abstract
Context: The increasing incidence of secondary caries and the failure of restorations have intensified research into dental restorative materials capable of actively interacting with the oral environment. In this context, antibacterial and bioregenerative nanomaterials have attracted growing scientific interest due to their potential [...] Read more.
Context: The increasing incidence of secondary caries and the failure of restorations have intensified research into dental restorative materials capable of actively interacting with the oral environment. In this context, antibacterial and bioregenerative nanomaterials have attracted growing scientific interest due to their potential to inhibit biofilm formation while simultaneously supporting mineral repair processes. Objective: This narrative review analyzes recent developments in nanostructured materials for restorative dentistry and oral health applications, with particular emphasis on antibacterial agents, bioactive systems, and emerging dual-function approaches that integrate multiple biological functions into restorative materials. Scope of the Review: The analyzed literature indicates that metallic nanoparticles, cationic monomers, and natural nanopolymers can reduce bacterial adhesion and metabolic activity under experimental conditions. In parallel, bioactive nanomaterials such as nanohydroxyapatite, bioactive glass, and calcium phosphate-based systems have demonstrated the ability to release remineralizing ions and to promote mineral deposition at the tooth–material interface. Dual-function hybrid materials aim to combine these antibacterial and bioregenerative effects within a single restorative system. Interpretative Perspective: Despite these advances, most available evidence derives from in vitro and preclinical studies, with significant heterogeneity across experimental models, evaluation methods, and outcome variables. This variability limits direct comparisons between studies and necessitates a cautious interpretation of claims regarding long-term antibacterial efficacy, functional tissue regeneration, and routine clinical applicability. Conclusions: Antibacterial and bioregenerative nanomaterials represent a relevant and continuously evolving research direction in restorative dentistry. Their successful clinical translation will depend on establishing standardized testing protocols, conducting comprehensive safety assessments, and generating clinically relevant evidence supporting long-term efficacy and biological compatibility. Their successful clinical translation will depend on establishing standardized testing protocols, conducting comprehensive safety assessments, and generating clinically relevant evidence supporting long-term efficacy and biological compatibility. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Oral Health: From Dental Restoration to Regenerative Therapies)
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