Extrapulmonary Manifestations and Complications of Viral Pneumonia
A topical collection in Journal of Clinical Medicine (ISSN 2077-0383). This collection belongs to the section "Respiratory Medicine".
Editor
Interests: systemic sclerosis; autoimmune diseases; immunology; vascular medicine; internal medicine; cardiovascular risk; cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
The novel beta-coronavirus SARS-CoV-2, related to severe acute respiratory distress syndrome, is currently pandemic. Most patients have respiratory symptoms such as fever, cold, cough, and shortness of breath. However, different clinical manifestations can be observed, from asymptomatic cases to mild and nonspecific symptoms or severe complications such as acute respiratory distress and death.
Although COVID-19 is most known for causing respiratory pathology, it can also result in several extrapulmonary manifestations that include: thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, dermatologic complications.
Given that ACE2, the entry receptor for the causative COVID-19, is ubiquitously expressed, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thrombo - inflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19.
Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 with particular attention to:
- Miocarditis, myocardial dysfunction and arrhythmia and acute coronary syndromes
- Neurological manifestation
- Vasculitis
- Thrombotic complications
Our work will therefore be a review of the most frequent extra - pulmonary manifestations of CPOVID19 with reference to rare forms such as cutaneous vasculitis and rare neurological manifestations (opsoclonus - myoclonus).
Dr. Antonino Mazzone
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- myocarditis
- neurological manifestation
- vasculitis
- skin disorders
- COVID19
- opsoclonus-myoclonus
- thrombo-inflammation
