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Oral Health and Systemic Diseases: Clinical Insights

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 1710

Special Issue Editor


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Guest Editor
Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: oral health; endodontics; orthodontic; periodontal disease; dental caries
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral health is a fundamental component of general well-being, yet it remains one of the most neglected aspects of global healthcare. The burden of oral diseases—including dental caries, periodontal disease, and other conditions with oral manifestations—continues to rise worldwide, affecting quality of life and contributing to significant systemic health complications. Increasing evidence reveals strong bidirectional relationships between oral and systemic diseases such as diabetes, cardiovascular disorders, and autoimmune conditions. Despite these connections, the integration of oral medicine into broader healthcare systems remains limited, highlighting an urgent need for interdisciplinary research and preventive strategies.

This Special Issue aims to explore innovative approaches to oral care, prevention, and disease management, emphasizing the importance of early diagnosis, minimally invasive treatments, and the role of biotechnology and personalized medicine in modern dentistry. Contributions are encouraged that address the mutual influence between oral and systemic health, novel diagnostic tools, preventive programs, and clinical interventions.

We invite researchers and clinicians to submit original research articles and reviews that advance our understanding of the interplay between oral and systemic diseases. By uniting diverse expertise across the fields of oral medicine, dentistry, and preventive healthcare, this Special Issue seeks to foster innovative strategies for achieving sustainable improvements in global oral health.

Dr. Fabio Piras
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral health
  • endodontics
  • orthodontic
  • periodontal disease
  • dental caries

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Published Papers (1 paper)

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Research

11 pages, 597 KB  
Article
The Influence of Passive Ultrasonic Irrigation (PUI) on the Healing of Maxillary Sinusitis of Endodontic Origin (MSEO) After Non-Surgical Endodontic Treatment
by Paweł Szczurowski, Michał Gontarz, Krzysztof Gronkiewicz, Piotr Majewski and Barbara Czopik
J. Clin. Med. 2026, 15(6), 2454; https://doi.org/10.3390/jcm15062454 - 23 Mar 2026
Viewed by 1293
Abstract
Background/Objectives: Half of diagnosed unilateral maxillary sinusitis may have odontogenic origin, and root canal treatment (RCT) can be beneficial as a single-mode treatment for full resolution of maxillary sinusitis of endodontic origin (MSEO) symptoms. The aim of the study was to investigate [...] Read more.
Background/Objectives: Half of diagnosed unilateral maxillary sinusitis may have odontogenic origin, and root canal treatment (RCT) can be beneficial as a single-mode treatment for full resolution of maxillary sinusitis of endodontic origin (MSEO) symptoms. The aim of the study was to investigate the influence of passive ultrasonic irrigation (PUI) on the healing of MSEO after non-surgical endodontic treatment. Methods: A single-center, retrospective study was conducted on CBCT data and medical records of 240 patients, who underwent non-surgical endodontic treatment, performed by the same operator between 2016 and 2025. One hundred and thirty-six teeth entered the study due to inclusion/exclusion criteria. Results: Complete healing was observed in 75.74% of the cases (n = 103). The tooth most frequently associated with MSEO was the first upper molar (52.21%, n = 71). PUI was applied in 66.91% of the treatments (n = 91). PUI was an independent predictor of MSEO healing (p = 0.001; 95% CI [1.768; 9.136]). When PUI was introduced in RCT, complete healing of MSEO was observed in 84.62% of the cases (n = 77). PUI was independently associated with higher odds of radiological resolution of MSEO in univariate logistic regression (OR = 4.019) and multiple logistic regression (OR = 12.388) models. Conclusions: PUI application in the irrigation protocol was associated with higher rates of MSEO healing after non-surgical endodontic treatment (p = 0.001; 95% CI [1.768; 9.136]). The rate of MSEO healing after non-surgical RCT is high (75.74%); therefore it should be considered as a single-mode treatment option in cases of unilateral maxillary sinusitis. Full article
(This article belongs to the Special Issue Oral Health and Systemic Diseases: Clinical Insights)
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