Current Challenges and Advances in Pediatric Thrombosis
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".
Deadline for manuscript submissions: closed (20 July 2021) | Viewed by 19750
Special Issue Editor
Special Issue Information
Dear Colleagues,
The incidence of thrombosis in the pediatric population is increasing. This phenomenon is related not only to the occurrence of complications in critically ill children and neonates, but also to the increased awareness about this issue and the development of more sensitive diagnostic tools for the identification of thrombosis.
The epidemiology of VTE is very different in neonates compared with children, adolescents, and young adults.
Unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) followed by vitamin K antagonists has been the treatment of choice for most patients with VTE, with the aim of preventing thrombus extension or embolization and recurrent VTE. Patients with permanent risk factors or patients with recurrent DVT or PE require life-long secondary prevention. Over the last few years, new oral anticoagulant agents have been developed and are now undergoing extensive clinical evaluation in several settings, including the treatment of VTE. The encouraging results of the first completed clinical trials suggest that a new era in the management of VTE is beginning.
Several key issues deserve particular attention and need to be resolved in this patient population, namely: a) risk factors and patients at risk; b) the optimal diagnostic tests to perform; c) a more precise target population to screen and treat pre-emptively; and d) the role of thrombolysis.
Dr. Matteo Luciani
Guest Editor
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Keywords
- arterial thrombosis
- venous thrombosis
- pediatric
- anticoagulant
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