Pathophysiology, Diagnosis, and Management of Portal Vein Thrombosis
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: closed (25 December 2022) | Viewed by 6097
Special Issue Editors
2. Group of Clinical and Translational Research in Digestive Diseases, Health Research Institute Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain
3. Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBERehd), 28029 Madrid, Spain
Interests: liver transplantation; immunosuppression; rejection; graft dysfunction; cirrhosis; acute-on-chronic liver failure; portal vein thrombosis; vascular liver diseases
Special Issue Information
Dear Colleagues,
Portal Vein Thrombosis (PVT) is a heterogeneous condition with respect to etiology, manifestations, natural history, and therapeutic options. PVT is rare in patients without cirrhosis in whom it usually develops in the presence of an underlying prothrombotic condition. In the setting of cirrhosis, however, PVT is a frequent event that occurs in 0.6 to 15.8% of patients depending on the severity of liver disease. Once PVT is present, its impact on the natural history of cirrhosis is not clear, raising the question of whether PVT is the consequence or the cause of liver disease progression. Nevertheless, in the liver transplant (LT) candidate, the presence of PVT at the time of transplant is associated with increased posttransplant mortality, especially in cases of extensive PVT thromboses requiring nonanatomic venous anastomoses or bypass grafts that increase the technical challenge. Moreover, in some patients with cirrhosis, whether to treat PVT or not is still a debatable issue, given its controversial impact on the natural history and prognosis. In recent years, there have been important advances in the diagnosis, characterization and treatment of this entity, such as the advancement of endovascular treatment (i.e., transjugular intrahepatic portosystemic shunt or portal vein recanalization). However, there are still many unknowns about the pathophysiology, precipitating risk factors, natural history and treatment, which must be clarified in the coming years by well-designed studies.
With this Special Issue, we hope to encourage submissions that discuss the current state of the art, address existing knowledge gaps, and focus on ongoing controversies related to the pathogenesis, diagnostic, prognosis, and therapeutic management of portal vein thrombosis and its complications.
Dr. Antonio Cuadrado
Dr. Ángela Puente
Guest Editors
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Keywords
- portal vein thrombosis
- cirrhosis
- liver transplant
- portal hypertension
- anticoagulants
- transjugular intrahepatic portosystemic shunt
- TIPS
- portal vein recanalization
- non-cirrhotic portal vein obstruction
- thrombophilic conditions
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