jcm-logo

Journal Browser

Journal Browser

Perspectives on the Diagnosis and Treatment of Cardiomyopathies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 459

Special Issue Editor


E-Mail
Guest Editor
Cardiology Unit, Madre Giuseppina Vannini Hospital, Rome, Italy
Interests: takotsubo syndrome; cardiomyopathy; cardiac magnetic resonance; cardiovascular imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiomyopathies represent a diverse group of myocardial disorders that pose significant diagnostic and therapeutic challenges. Recent advances in imaging technologies, molecular diagnostics, and pharmacological therapies are transforming the clinical landscape, offering new opportunities for precision medicine in this field.

This Special Issue invites original research articles, reviews, and clinical perspectives that explore emerging tools and strategies to improve the care of patients with cardiomyopathy.

We are particularly interested in contributions addressing the following themes:

  • Cardiac Imaging: The expanding role of advanced imaging modalities—including echocardiography, cardiac magnetic resonance, computed tomography and nucear imaging—in the early detection and accurate phenotyping of cardiomyopathies.
  • Genetic Testing: The integration of genomic insights into clinical practice, including the role of next-generation sequencing and polygenic risk scores in refining diagnosis and guiding family screening.
  • Novel Pharmacological Therapies: Innovations in drug development for specific cardiomyopathy subtypes, including myosin inhibitors, gene-targeted therapies, and disease-modifying agents that reflect a shift toward a mechanism-based treatment.

This Special Ossue aims to provide a comprehensive overview of contemporary approaches to diagnosing and treating cardiomyopathies, bridging the gap between research and clinical application.

Dr. Luca Arcari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiomyopathies
  • hypertrophic cardiomyopathy
  • dilated cardiomyopathy
  • cardiac amyloidosis
  • arrhythmogenic right ventricular cardiomyopathy
  • non-dilated left ventricular cardiomyopathy
  • cardiac magnetic resonance imaging
  • computed tomography
  • echocardiography
  • nuclear imaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

17 pages, 1885 KB  
Review
Non-Invasive Diagnostic Algorithm in Transthyretin Cardiac Amyloidosis: Is Bone Scintigraphy Always Enough?
by Giulia Marchionni, Giulia Pecci, Maria Alfarano, Jacopo Costantino, Federico Ballatore, Federico Ciccarelli, Antonio Lattanzio, Nicola Galea, Giuseppe De Vincentis and Cristina Chimenti
J. Clin. Med. 2025, 14(23), 8458; https://doi.org/10.3390/jcm14238458 (registering DOI) - 28 Nov 2025
Viewed by 296
Abstract
Technetium-99m bone scintigraphy has revolutionized the non-invasive diagnosis of transthyretin cardiac amyloidosis (ATTR-CM) and markedly increased disease recognition. Although this technique should ideally be applied in patients with a high pre-test probability of ATTR-CM, its use in other clinical settings may reveal incidental [...] Read more.
Technetium-99m bone scintigraphy has revolutionized the non-invasive diagnosis of transthyretin cardiac amyloidosis (ATTR-CM) and markedly increased disease recognition. Although this technique should ideally be applied in patients with a high pre-test probability of ATTR-CM, its use in other clinical settings may reveal incidental pathological myocardial uptake that prompts referral to specialized centers even in the absence of typical red flags. In such cases, where confounding factors such as left ventricular hypertrophy from alternative causes may coexist, awareness of potential pitfalls and the integration of scintigraphic findings with clinical features, biomarkers, and echocardiographic data are essential to avoid misdiagnosis and inappropriate therapy. Cardiac magnetic resonance (CMR) imaging provides a crucial complementary role, offering refined tissue characterization, improved differential diagnosis, and valuable prognostic insights. A combined approach that situates scintigraphy within the broader clinical context and incorporates CMR in ambiguous cases is fundamental to ensure an accurate diagnosis and optimal patient management. Full article
(This article belongs to the Special Issue Perspectives on the Diagnosis and Treatment of Cardiomyopathies)
Show Figures

Figure 1

Back to TopTop