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New Insights into Fertility Preservation in Female Benign Conditions
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New Insights into Fertility Preservation in Female Benign Conditions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 2677

Special Issue Editor

Prof. Dr. Michelle Nisolle

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Hospital de La Citadelle, University of Liege, B-4000 Liege, Belgium
Interests: endometriosis; adenomyosis; mullerian anomalies; fibroids; ovarian cyst; endoscopic surgery fertility preservation; cryopreservation; female genital diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fertility preservation is common in patients whose fertility is compromised due to health conditions or diseases. Usually, it is associated with malignant pathologies, but there are also many benign clinical situations requiring particular attention for fertility preservation.

Among benign female genital diseases, endometriosis is largely debated in the literature, especially in ovarian endometriosis surgery, as premature ovarian failure can occur.

Uterine fibroids and adenomyosis are frequently surgically managed in order to protect or restore fertility and, in some cases, alternative technologies are suggested, such as uterine artery embolization.

Care must also be taken when dealing with young patients with Turner syndrome, in transgender patients, as well as in patient affected by autoimmune or benign hematological diseases.

In this Special Issue, we aim to focus on fertility-sparing surgery for benign conditions frequently encountered in practice.

Prof. Dr. Michelle Nisolle
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fertility preservation
  • endometriosis
  • female genital diseases
  • adenomyosis
  • autoimmune diseases
  • benign hematological disease
  • Turner syndrome
  • uterine fibroids
  • transgender

Published Papers (2 papers)

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Research

15 pages, 1552 KiB  
Article
Reproductive Outcomes of Women with Turner Syndrome Undergoing Oocyte Vitrification: A Retrospective Multicenter Cohort Study
by Sapthami Nadesapillai, Femke Mol, Simone L. Broer, Linda B. P. M. Stevens Brentjens, Marieke O. Verhoeven, Karst Y. Heida, Mariëtte Goddijn, Ron J. T. van Golde, Annelies M. E. Bos, Sanne van der Coelen, Ronald Peek, Didi D. M. Braat, Janielle A. E. M. van der Velden and Kathrin Fleischer
J. Clin. Med. 2023, 12(20), 6502; https://doi.org/10.3390/jcm12206502 - 13 Oct 2023
Cited by 1 | Viewed by 968
Abstract
Background: Turner syndrome (TS) is accompanied with premature ovarian insufficiency. Oocyte vitrification is an established method to preserve fertility. However, data on the oocyte yield in women with TS who vitrify their oocytes and the return rate to utilize the oocytes are scarce. [...] Read more.
Background: Turner syndrome (TS) is accompanied with premature ovarian insufficiency. Oocyte vitrification is an established method to preserve fertility. However, data on the oocyte yield in women with TS who vitrify their oocytes and the return rate to utilize the oocytes are scarce. Methods: Retrospective multicenter cohort study. Data was collected from medical records of women with TS who started oocyte vitrification between 2010 and 2021. Results: Thirty-three women were included. The median cumulative number of vitrified oocytes was 20 per woman. Complications occurred in 4% of the cycles. Significant correlations were found between the cumulative number of vitrified oocytes and AMH (r = 0.54 and p < 0.01), AFC (r = 0.49 and p < 0.01), percentage of 46,XX cells (r = 0.49 and p < 0.01), and FSH (r = −0.65 and p < 0.01). Spontaneous (n = 8) and IVF (n = 2) pregnancies occurred in 10 women ± three years after vitrification. So far, none of the women have returned to utilize their vitrified oocytes. Conclusions: Oocyte vitrification is a feasible fertility preservation option for women with TS, particularly in those with 46,XX cell lines or sufficient ovarian reserve. Multiple stimulation cycles are recommended to reach an adequate number of vitrified oocytes for pregnancy. It is too early to draw conclusions about the utilization of vitrified oocytes in women with TS. Full article
(This article belongs to the Special Issue New Insights into Fertility Preservation in Female Benign Conditions)
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11 pages, 761 KiB  
Article
Co-Existence of Endometriosis with Ovarian Dermoid Cysts: A Retrospective Cohort Study
by Dimitrios Rafail Kalaitzopoulos, Nicolas Samartzis, Markus Eberhard, Georgios Grigoriadis, Dimosthenis Miliaras, Alexis Papanikolaou and Angelos Daniilidis
J. Clin. Med. 2023, 12(19), 6308; https://doi.org/10.3390/jcm12196308 - 30 Sep 2023
Viewed by 1426
Abstract
Both endometriosis and ovarian dermoid cysts are benign conditions characterized by the presence of well-differentiated tissues in ectopic locations. The presence and surgical excision of these entities can potentially impact ovarian reserves, contributing to reduced chances of future pregnancy. The objective of our [...] Read more.
Both endometriosis and ovarian dermoid cysts are benign conditions characterized by the presence of well-differentiated tissues in ectopic locations. The presence and surgical excision of these entities can potentially impact ovarian reserves, contributing to reduced chances of future pregnancy. The objective of our study is to investigate the bidirectional association between endometriosis and ovarian dermoid cysts, as well as to analyze the clinical characteristics of patients diagnosed with both conditions. A retrospective cohort study was conducted, including women who underwent laparoscopy and received histological diagnoses of endometriosis and/or dermoid cysts between 2011 and 2019 at the Cantonal Hospital of Schaffhausen. We identified 985 women with endometriosis and 83 women with ovarian dermoid cysts. Among these groups, 22 women presented with both endometriosis and ovarian dermoid cysts. The majority of the above patients had endometriosis stage rASRM I-II (72.7%), with peritoneal endometriosis being the most common phenotype of endometriosis (77.2%). Out of the 14 patients with a desire for future pregnancy, the majority (11/14, 78.5%) had an EFI score of 7–8. The prevalence of bilateral ovarian dermoid cysts was higher in women with both ovarian dermoid cysts and endometriosis in comparison to women with ovarian dermoid cysts without endometriosis (18% vs. 6.5%). Our study revealed that 26.5% of women with ovarian dermoid cysts also had endometriosis, a notably higher prevalence than observed in the general population. Clinicians should be aware of this co-existence, and preoperative counseling should be an integral part of the care plan for affected individuals, where the potential risks and the available options for fertility preservation should be discussed in detail. Full article
(This article belongs to the Special Issue New Insights into Fertility Preservation in Female Benign Conditions)
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