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Recent Advances in the Management of Colorectal Cancer
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Recent Advances in the Management of Colorectal Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (25 September 2024) | Viewed by 4463

Special Issue Editors

Prof. Dr. Octav Ginghinǎ

E-Mail Website
Guest Editor
1. Department of General Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2. Institute of Oncology Prof. Dr. Alexandru Trestioreanu, Șoseaua Fundeni 252, 022328 Bucharest, Romania
Interests: gastrointestinal malignancies; colorectal cancer; surgical oncology
Dr. Mihai Constantin Ceausu

E-Mail Website
Guest Editor
Pathology Department of the "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Interests: colorectal cancer; colorectal surgery; cancer diagnostics; immunohistochemistry; surgical oncology

Special Issue Information

Dear Colleagues,

We are glad to announce a new Special Issue entitled “Recent Advances in the Management of Colorectal Cancer” for the Journal of Clinical Medicine. Colorectal Cancer (CRC) ranks as the third most prevalent form of cancer globally and represents a significant contributor to cancer-related deaths. In recent years, the management of colorectal cancer has made significant advances. This has been achieved, on the one hand, due to the thorough research conducted on colorectal cancer by clinicians, surgeons, and pathologists; on the other hand, significant progress has been achieved in conjunction with advancements in surgical techniques, the accumulation of surgical expertise, and the implementation of multidisciplinary treatments.

The aim of this Special Issue is to present recent advances in the multidisciplinary approach to colorectal cancer and the assessment of clinicopathological patterns in colorectal cancer. Therefore, we kindly invite you to contribute to the topics of this Special Issue and submit your manuscripts (review or original), in order to enhance and update the scientific knowledge related to this fascinating field.

Prof. Dr. Octav Ginghinǎ
Dr. Mihai Constantin Ceausu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • gastrointestinal malignancies
  • colorectal surgery
  • surgical oncology
  • treatment modalities

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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19 pages, 33194 KiB  
Article
A 3D-Printed, High-Fidelity Pelvis Training Model: Cookbook Instructions and First Experience
by Radu Claudiu Elisei, Florin Graur, Amir Szold, Răzvan Couți, Sever Cãlin Moldovan, Emil Moiş, Călin Popa, Doina Pisla, Calin Vaida, Paul Tucan and Nadim Al-Hajjar
J. Clin. Med. 2024, 13(21), 6416; https://doi.org/10.3390/jcm13216416 - 26 Oct 2024
Viewed by 1279
Abstract
Background: Since laparoscopic surgery became the gold standard for colorectal procedures, specific skills are required to achieve good outcomes. The best way to acquire basic and advanced skills and reach the learning curve plateau is by using dedicated simulators: box-trainers, video-trainers and virtual [...] Read more.
Background: Since laparoscopic surgery became the gold standard for colorectal procedures, specific skills are required to achieve good outcomes. The best way to acquire basic and advanced skills and reach the learning curve plateau is by using dedicated simulators: box-trainers, video-trainers and virtual reality simulators. Laparoscopic skills training outside the operating room is cost-beneficial, faster and safer, and does not harm the patient. When compared to box-trainers, virtual reality simulators and cadaver models have no additional benefits. Several laparoscopic trainers available on the market as well as homemade box and video-trainers, most of them using plastic boxes and standard webcams, were described in the literature. The majority of them involve training on a flat surface without any anatomical environment. In addition to their demonstrated benefits, box-trainers which add anatomic details can improve the training quality and skills development of surgeons. Methods: We created a 3D-printed anatomic pelvi-trainer which offers a real-size narrow pelvic space environment for training. The model was created starting with a CT-scan performed on a female pelvis from the Anatomy Museum (Cluj-Napoca University of Medicine and Pharmacy, Romania), using Invesalius 3 software (Centro de Tecnologia da informação Renato Archer CTI, InVesalius open-source software, Campinas, Brazil) for segmentation, Fusion 360 with Netfabb software (Autodesk software company, Fusion 360 with Netfabb, San Francisco, CA, USA) for 3D modeling and a FDM technology 3D printer (Stratasys 3D printing company, Fortus 380mc 3D printer, Minneapolis, MN, USA). In addition, a metal mold for casting silicone valves was made for camera and endoscopic instruments ports. The trainer was tested and compared using a laparoscopic camera, a standard full HD webcam and “V-Box” (INTECH—Innovative Training Technologies, Milano, Italia), a dedicated hard paper box. The pelvi-trainer was tested by 33 surgeons with different qualifications and expertise. Results: We made a complete box-trainer with a versatile 3D-printed pelvi-trainer inside, designed for a wide range of basic and advanced laparoscopic skills training in the narrow pelvic space. We assessed the feedback of 33 surgeons regarding their experience using the anatomic 3D-printed pelvi-trainer for laparoscopic surgery training in the narrow pelvic space. Each surgeon tested the pelvi-trainer in three different setups: using a laparoscopic camera, using a webcam connected to a laptop and a “V-BOX” hard paper box. In the experiments that were performed, each participant completed a questionnaire regarding his/her experience using the pelvi-trainer. The results were positive, validating the device as a valid tool for training. Conclusions: We validated the anatomic pelvi-trainer designed by our team as a valuable alternative for basic and advanced laparoscopic surgery training outside the operating room for pelvic organs procedures, proving that it supports a much faster learning curve for colorectal procedures without harming the patients. Full article
(This article belongs to the Special Issue Recent Advances in the Management of Colorectal Cancer)
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18 pages, 1032 KiB  
Article
A Glimpse into the Role and Effectiveness of Splenectomy for Isolated Metachronous Spleen Metastasis of Colorectal Cancer Origin: Long-Term Survivals Can Be Achieved
by Beatrice Mihaela Tivadar, Traian Dumitrascu and Catalin Vasilescu
J. Clin. Med. 2024, 13(8), 2362; https://doi.org/10.3390/jcm13082362 - 18 Apr 2024
Viewed by 1434
Abstract
Background: Many papers exploring the role of resectioning metastases in colorectal cancer (CRC) have focused mainly on liver and lung sites, showing improved survival compared with non-resectional therapies. However, data about exceptional metastatic sites such as splenic metastases (SMs) are scarce. This [...] Read more.
Background: Many papers exploring the role of resectioning metastases in colorectal cancer (CRC) have focused mainly on liver and lung sites, showing improved survival compared with non-resectional therapies. However, data about exceptional metastatic sites such as splenic metastases (SMs) are scarce. This paper aims to assess the role and effectiveness of splenectomy in the case of isolated metachronous SM of CRC origin. Methods: The patients’ data were extracted after a comprehensive literature search through public databases for articles reporting patients with splenectomies for isolated metachronous SM of CRC origin. Potential predictors of survival were explored, along with demographic, diagnostic, pathology, and treatment data for each patient. Results: A total of 83 patients with splenectomies for isolated metachronous SM of CRC origin were identified. The primary CRC was at an advanced stage (Duke’s C—70.3%) and on the left colon (45.5%) for most patients, while the median interval between CRC resection and SM was 24 months. The median overall survival after splenectomy was 84 months, and patients younger than 62 years presented statistically significantly worse overall survival rates than those ≥62 years old (p = 0.011). There was no significant impact on the long-term outcomes for factors including primary tumor location or adjuvant chemotherapy (p values ≥ 0.070, ns). Laparoscopic splenectomy was increasingly used in the last 20 years from 2002 (33.3% vs. 0%, p < 0.001). Conclusions: Splenectomy is the optimal treatment for patients with isolated metachronous SM of CRC, with the laparoscopic approach being increasingly used and having the potential to become a standard of care. Encouraging long-term survival rates were reported in the context of a multidisciplinary approach. Younger ages are associated with worse survival. Perioperative chemotherapy in the context of a patient diagnosed with SM of CRC origin appears to be a reasonable option, although the present study failed to show any significant impact on long-term survival. Full article
(This article belongs to the Special Issue Recent Advances in the Management of Colorectal Cancer)
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Review

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17 pages, 2157 KiB  
Review
Pancreaticoduodenectomies with Concurrent Colectomies: Indications, Technical Issues, Complications, and Oncological Outcomes
by Traian Dumitrascu
J. Clin. Med. 2023, 12(24), 7682; https://doi.org/10.3390/jcm12247682 - 14 Dec 2023
Cited by 3 | Viewed by 1225
Abstract
Multi-visceral resections for colon and pancreatic cancer (PDAC) are feasible, safe, and justified for early and late outcomes. However, the use of pancreaticoduodenectomy (PD) with concurrent colectomies is highly debatable in terms of morbidity and oncological benefits. Based on current literature data, this [...] Read more.
Multi-visceral resections for colon and pancreatic cancer (PDAC) are feasible, safe, and justified for early and late outcomes. However, the use of pancreaticoduodenectomy (PD) with concurrent colectomies is highly debatable in terms of morbidity and oncological benefits. Based on current literature data, this review assesses the early and long-term outcomes of PD with colectomies. The association represents a challenging but feasible option for a few patients with PDAC or locally advanced right colon cancer when negative resection margins are anticipated because long-term survival can be achieved. Concurrent colectomies during PD should be cautiously approached because they may significantly increase complication rates, including severe ones. Thus, patients should be fit enough to overcome potential severe complications. Patients with PD and colectomies can be classified as borderline resectable, considering the high risk of developing postoperative complications. Carefully selecting patients suitable for PD with concurrent colectomies is paramount to mitigate the potentially severe complications of the two surgical procedures and maximize the oncological benefits. These procedures should be performed at high-volume centers with extensive experience in pancreatectomies and colectomies, and each patient situation should be assessed using a multimodal approach, including high-quality imaging and neoadjuvant therapies, in a multidisciplinary team discussion. Full article
(This article belongs to the Special Issue Recent Advances in the Management of Colorectal Cancer)
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