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Acute Myocardial Infarction: Clinical Treatment and Management
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Acute Myocardial Infarction: Clinical Treatment and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 2138

Special Issue Editors

Dr. Lucia Ilaria Birtolo

E-Mail Website
Guest Editor
Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
Interests: heart failure (HF); ischemic heart diseases (IHD); clinical treatment and management; cardiovascular intensive care; advanced cardiac imaging; cardiac magnetic resonance (CMR)
Prof. Dr. Andrea Flex

E-Mail Website
Guest Editor
Cardiovascular Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy
Interests: heart failure (HF); ischemic heart diseases (IHD); clinical treatment and management; cardiovascular intensive care; advanced cardiac imaging; cardiac magnetic resonance (CMR)

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the clinical treatment and management of acute myocardial infarction.

Acute myocardial infarction is a leading cause of mortality and morbidity in the world.

Particularly, Special Issue will pay special attention to the management of mechanical, arrhythmic and hemodynamic complications and acute and/or chronic medical treatments, such as antitrombotic, lipid-lowering and invasive treatments.

Furthermore, imaging techniques are essential in the evaluation of patients with myocardial infarction. They are of value for both the initial assessment of the ischemic injury and for the detection of those higher risk of developing cardiovascular issues during the follow-up. In this setting, this Special Issue will also focuses on the role of CMR in myocardial and microvascular injury characterization and providing prognosis information.

This Special Issue aims to collect broader and more comprehensive knowledge to provide an overview of the latest advancements and future perspectives in the specialties involved in the management of acute myocardial infarction.

  1. Acute myocardial infarction;
  2. Ischemic heart disease (IHD);
  3. Clinical treatment and management;
  4. Cardiovascular intensive care;
  5. Acute coronary syndrome (ACS) complications;
  6. Cardiac imaging;
  7. Echocardiography;
  8. Cardiac magnetic resonance (CMR).

Dr. Lucia Ilaria Birtolo
Prof. Dr. Andrea Flex
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute myocardial infarction
  • ischemic heart diseases (IHD)
  • clinical treatment and management
  • cardiovascular intensive care
  • acute coronary syndrome (ACS) complications
  • cath lab
  • advanced cardiac imaging
  • advanced echocardiography
  • cardiac magnetic resonance (CMR)

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 2990 KiB  
Article
Novel Impact of Colchicine on Interleukin-10 Expression in Acute Myocardial Infarction: An Integrative Approach
by Saskia Dyah Handari, Mohammad Saifur Rohman, Djanggan Sargowo, Aulanni’am, Ricardo Adrian Nugraha, Bayu Lestari and Delvac Oceandy
J. Clin. Med. 2024, 13(16), 4619; https://doi.org/10.3390/jcm13164619 - 7 Aug 2024
Cited by 4 | Viewed by 1807
Abstract
Background: Inflammation plays a critical role in myocardial infarction as a critical process in the development of heart failure, involving the development of cardiac fibrosis. Colchicine is a well-established anti-inflammatory drug, but its scientific application in controlling post-acute myocardial infarction (AMI) inflammatory processes [...] Read more.
Background: Inflammation plays a critical role in myocardial infarction as a critical process in the development of heart failure, involving the development of cardiac fibrosis. Colchicine is a well-established anti-inflammatory drug, but its scientific application in controlling post-acute myocardial infarction (AMI) inflammatory processes has not been established. IL-10 is a key cytokine in modulating inflammatory responses, underscoring its potential as a crucial therapeutic target of colchicine. The objective was to explore the protective role of IL-10 modulated by colchicine in myocardial healing and repair following AMI, particularly cardiac fibrosis. Methods: The predicted protein of colchicine was assessed using WAY2DRUG PASS as probability active value. Proteins associated with colchicine, cardiac fibrosis, and acute myocardial infarction were analyzed with DisGeNET and Open Target databases. Analysis and visualization of protein–protein interactions were conducted using STRING and Cytoscape. A 3T3 cell line treated with CoCl2 was used to mimic hypoxic. HIF-1α and IL-10 expression were measured by flow cytometry and analyzed using a one-way ANOVA test. This observational clinical trial examined acute myocardial infarction patients undergoing immediate and delayed primary percutaneous coronary interventions. Subjects were randomized into control groups receiving placebo and intervention groups treated with colchicine. Assessments occurred at 24 h and five days after the intervention. IL-10 expression in the clinical trial was measured by ELISA and analyzed using a T-test. Results: Colchicine demonstrates promising bioactivity in treating acute myocardial infarction, with notably activity values highlighting its probable role as a tubulin antagonist (0.744), beta-tubulin antagonist (0.673), and NOS2 inhibitor (0.529). Its primary action targets IL-10, with the protein–protein interactions analysis indicating interactions between IL-10 and key inflammatory mediators—IL-1β, IFN-γ, CCL2, TNF, and TGF-β1—during acute myocardial infarction and cardiac fibrosis. Hypoxic conditions in the CoCl2-induced 3T3 cell model show significantly elevated HIF-1α compared to controls (p < 0.0001). Colchicine use significantly increased IL-10 expression in CoCl2-treated cells (p < 0.0001) and in AMI patients within five days (p < 0.05). Conclusions: Colchicine may bolster the anti-inflammatory response post-myocardial infarction by activating IL-10 pathways in fibroblasts and in clinical settings, potentially reducing inflammation after AMI. Further investigation into broader aspects of this pathway, particularly in cardiac fibroblasts, is required. Full article
(This article belongs to the Special Issue Acute Myocardial Infarction: Clinical Treatment and Management)
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