Paroxysmal Nocturnal Haemoglobinuria (PNH)
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 7558
Special Issue Editor
Special Issue Information
Dear Colleagues,
PNH is an acquired disorder that can affect any age group, often targeting young adults. The disease can result in significant morbidity as well as early mortality. Over the last 15 years, the role of complement inhibition has had a significant impact on improving both quality and survival for patients with PNH. Concomitant management of the underlying bone marrow failure is often required and requires understanding of the two disease processes. While terminal complement inhibition has advanced therapy for PNH significantly, there is increasing interest in targeting the complement system proximally to eradicate the extravascular haemolysis that emerges when terminal complement therapeutics are used. This Special Issue will address the most recent and relevant scientific findings in the management of PNH.
Dr. Anita Hill
Guest Editor
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Keywords
- Intravascular haemolysis
- Extravascular haemolysis
- Complement inhibition
- Bone marrow failure
- Eculizumab
- Aplastic anaemia
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