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Clinical Management of Platelet Disorders
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Clinical Management of Platelet Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Epidemiology & Public Health".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2581

Special Issue Editors

Dr. Deirdra R. Terrell

E-Mail Website
Guest Editor
Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Interests: platelet disorders; immune thrombocytopenia (ITP); thrombotic thrombocytopenic purpura (TTP); patient reported outcomes; mixed-methods research; health disparities
Dr. Marshall A. Mazepa

E-Mail Website
Guest Editor
Division Hematology and Oncology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Interests: rare blood disorders; thrombotic microangiopathies; acquired thrombotic thrombocytopenic purpura; disorders of hemostasis and thrombosis; hemophilia; hematology

Special Issue Information

Dear Colleagues,

Disorders of platelet number and function impact patients in various ways. They can leave patients at risk of bleeding or thrombosis, and also affect patients' quality of life. Regarding these diseases, there have been recent changes in the diagnostic tools and therapeutic approaches used, and these changes are also impacting patients.

We are looking to publish a Special Issue in the Journal of Clinical Medicine dedicated to topics surrounding platelet disorders. We encourage the submission of articles including, but not limited to, the following: immune thrombocytopenia (ITP), thrombotic microangiopathies, congenital (or pediatric) thrombocytopenia, thrombocytosis, heparin-induced thrombocytopenia or vaccine-induced thrombotic thrombocytopenia. We encourage you and your colleagues to submit your latest research or reviews related to the diagnosis, differential diagnosis, treatment, and any issues surrounding the management of patients with platelet disorders.

Dr. Deirdra R. Terrell
Dr. Marshall A. Mazepa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelet disorders
  • bleeding
  • thrombosis
  • thrombocytopenia
  • thrombocytosis
  • immune thrombocytopenia (ITP)
  • heparin-induced thrombocytopenia
  • vaccine-induced thrombotic thrombocytopenia
  • thrombotic microangiopathies
  • diagnostic
  • therapeutic approaches

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

12 pages, 238 KiB  
Article
Predictive Value of Centered Clinical Asymmetric Lower Limb Edema in Diagnosing Deep Vein Thrombosis in Puerperium
by Catalina Filip, Daniela Roxana Matasariu, Alexandra Ursache, Cristina Furnica, Gabriel Ioan Anton, Cristiana Filip, Vasile Lucian Boiculese, Demetra Gabriela Socolov and Raluca Ozana Chistol
J. Clin. Med. 2025, 14(10), 3320; https://doi.org/10.3390/jcm14103320 - 9 May 2025
Viewed by 355
Abstract
Background: Peripheral vein thrombosis during pregnancy poses serious diagnostic challenges due to the intertwining of its clinical symptoms with normal pregnancy modifications. Methods: We analyzed and compared the paraclinical test results of singleton pregnant women and women in the first six weeks postpartum [...] Read more.
Background: Peripheral vein thrombosis during pregnancy poses serious diagnostic challenges due to the intertwining of its clinical symptoms with normal pregnancy modifications. Methods: We analyzed and compared the paraclinical test results of singleton pregnant women and women in the first six weeks postpartum who presented with significant lower limb inequality. Results: Our data revealed three predictors of deep vein thrombosis (DVT): mean platelet volume (MPV), with a one-unit increase in MPV being associated with a 1.497-fold higher risk of thrombosis (p = 0.008); platelet distribution width (PDW), with a one-unit decrease in PDW increasing thrombosis risk (odds ratio (OR) = 1.17, p = 0.003); anemia, with its presence increasing the risk of thrombosis by 8.46 times (p = 0.003); and fibrinogen, with a one-unit increase in its level increasing DVT risk 1.003-fold. Conclusions: Significant lower limb inequality might be used as a predictor of DVT during puerperium. Full article
(This article belongs to the Special Issue Clinical Management of Platelet Disorders)
14 pages, 943 KiB  
Article
Implementation of Primary Immune Thrombocytopenia Clinical Practice Guidelines for Management of Pregnancy
by Amanda J. Llaneza, Laura A. Beebe, Janis E. Campbell, Marshall K. Cheney, Ying Zhang and Deirdra R. Terrell
J. Clin. Med. 2024, 13(21), 6477; https://doi.org/10.3390/jcm13216477 - 29 Oct 2024
Cited by 1 | Viewed by 1708
Abstract
Background: Managing primary immune thrombocytopenia (ITP) in pregnancy is challenging. Providers must balance bleeding risk against medication toxicity. The evaluation of the implementation of pregnancy-specific ITP clinical guidelines has not been widely studied. The goal of this study was to describe the implementation [...] Read more.
Background: Managing primary immune thrombocytopenia (ITP) in pregnancy is challenging. Providers must balance bleeding risk against medication toxicity. The evaluation of the implementation of pregnancy-specific ITP clinical guidelines has not been widely studied. The goal of this study was to describe the implementation of pregnancy-specific ITP guidelines at an academic health center. Methods: We conducted a retrospective chart review at the University of Oklahoma Health system from 2011 to 2020. Descriptive statistics were calculated to summarize the characteristics of the study population. Management, according to the clinical guidelines (American Society of Hematology; American College of Obstetricians and Gynecologists) was evaluated during pregnancy and during/for delivery. Results: A total of 85 pregnant persons with ITP were included. The majority (68%; 58/85) delivered vaginally. There were 0 maternal deaths and 2 infant deaths. No patients had major bleeding during pregnancy. Postpartum hemorrhage was experienced by 14%. The management of thrombocytopenia during pregnancy was 100% adherent to the strong recommendation for severe (n = 13) and mild (n = 11) thrombocytopenia. However, 18/50 (36%) asymptomatic persons with moderate thrombocytopenia received treatment despite the strong recommendation that treatment was unnecessary. Additionally, 8/21 (38%) persons with moderate thrombocytopenia received treatment to increase platelet counts for epidural anesthesia despite the guideline’s suggestion that it was unnecessary. Conclusions: During pregnancy, patients with severe thrombocytopenia (i.e., most at risk of bleeding) received treatment. On the other hand, approximately 40% of pregnant persons with ITP received unnecessary treatment for moderate asymptomatic thrombocytopenia either during pregnancy or for an epidural. Utilizing clinical practice guidelines would reduce the overtreatment of pregnant persons which would reduce the potential side effects of therapy for the mother and infant. Full article
(This article belongs to the Special Issue Clinical Management of Platelet Disorders)
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