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Special Issue "Immunotherapy for Central Nervous System Tumors: Current and Future Directions"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Prof. Gary Kohanbash

Assistant Professor of Neurosurgery and Immunology, University of Pittsburgh, Pittsburgh, PA, USA
Website | E-Mail
Interests: Brain tumor, immunotherapy, immunosuppression, T-cells, tumor-associated macrophages, myeloid-derived suppressor cells

Special Issue Information

Dear Colleagues,

The field of brain tumor immunotherapy has been rapidly developing owing to advancements in clinical, translational, and basic research. Next-generation sequencing efforts continue to reveal new immunologic targets in the form of neoantigens and tumor-associated antigens. Basic research findings on T-cell biology continues to identify new promising checkpoint pathways, and the immune system’s contribution to oncolytic viral therapy has gained broad acceptance. However, clinical trials continue to be disappointing with failures in almost every prominent trial. Multiple factors likely contribute to these failed trials including immunosuppressive cells within the tumors, the expression of checkpoint molecules, and a relatively low mutational burden. A multidisciplinary approach to developing rational and effective combination therapies and to identifying which patients are likely to respond to each therapy is necessary. This Special Issue will focus on novel findings in basic, translational, and clinical research advancing the field of brain tumor immuno-oncology. We also welcome topics related to biomarkers, novel imaging approaches, and the analysis of correlative analyses of clinical trials. This Special Issue will present novel recent findings and an exploration of where the field is moving in developing immunotherapies for central nervous system tumors.

Prof. Gary Kohanbash
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Primary and metastatic CNS tumors
  • Tumor-associated macrophages
  • MDSCs
  • T-regulatory cells
  • oncolytic viral therapy
  • vaccines
  • checkpoint pathway inhibitors
  • T-cell therapies
  • CAR-T cells

Published Papers

This special issue is now open for submission.
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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