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Crohn’s Disease and Ulcerative Colitis: Pathophysiology and New Therapeutic Strategies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 1185

Special Issue Editors


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Guest Editor
Department of Gastroenterology, Nuffield Hospital, Scraptoft Lane, Leicester LE5 5HY, UK
Interests: irritable bowel syndrome;microscopic colitis; Crohn’s disease and ulcerative colitis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Gastroenterology, Nuffield Hospital, Scraptoft Lane, Leicester LE5 5HY, UK
Interests: inflammatory bowel disease; coeliac disease; achalasia; screening; epidemiology; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue concerns the recent therapeutic developments in the management of Crohn's Disease and Ulcerative Colitis. There will be a focus on the role of the intestinal microbiome in the development of Crohn's Disease and Ulcerative Colitis, and the therapeutic place of new probiotics in the management of these conditions. The Special Issue also reflects on the place of newer biologic therapies and JAK inhibitors in the control of inflammatory process. Stem cell therapy and other new drugs targeting the inflammatory process will also be reviewed. All studies and reviews relating to the mechanisms and therapeutic strategies of Crohn's Disease are welcome.

You may choose our Joint Special Issue in Biomedicines.

Dr. Affifa Farrukh
Prof. Dr. John Mayberry
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • probiotics
  • biologics
  • JAK inhibitors
  • stem cell therapy
  • new molecules

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Published Papers (1 paper)

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Research

12 pages, 741 KiB  
Article
Medication Burden Before and After Prescription of Biologics in Patients with Inflammatory Bowel Disease
by Annika Fernandez Milano, Sarah Krieg and Karel Kostev
J. Clin. Med. 2024, 13(21), 6408; https://doi.org/10.3390/jcm13216408 - 25 Oct 2024
Viewed by 841
Abstract
Background: Biologics are a cornerstone in the treatment of severe cases of inflammatory bowel disease (IBD) and aim to control the disease and improve quality of life. This study investigated changes in nonbiologic medication prescriptions for IBD patients initiating biologic therapy in Germany. [...] Read more.
Background: Biologics are a cornerstone in the treatment of severe cases of inflammatory bowel disease (IBD) and aim to control the disease and improve quality of life. This study investigated changes in nonbiologic medication prescriptions for IBD patients initiating biologic therapy in Germany. Methods: This study used data from anonymized pharmacy records in the German longitudinal prescription (LRx) database and included biologic-naive IBD patients who received their first biologic therapy prescription between 2016 and 2022. Changes in prescription rates and pill counts for nonbiologic medications (corticosteroids, 5-aminosalicylates (5-ASA), proton pump inhibitors, analgesics, immunosuppressants, Vitamin D, iron, and antibiotics) before and after the initiation of biologic therapy were assessed using descriptive statistics, McNemar’s tests, and Poisson regression models, adjusting for age and sex. Results: A total of 29,559 biologic-naive IBD patients were included. Prior to index, 91.2% received at least one nonbiologic medication prescription, where corticosteroids and 5-ASA were the most common. Postindex, the overall prescription rate decreased to 87.7%, with significant reductions in prescriptions observed for corticosteroids, 5-ASA, and immunosuppressants (p-values < 0.001). The mean (SD) pill count dropped from 704 (1712) to 514 (1651), with the largest mean differences (95% CI) having been for corticosteroids (−77.9 [−80.3 to −75.5]), 5-ASA (−61.6 [−65.2 to −58.1]), and immunosuppressants (−55.0 [−57.5 to −52.6]). Older patients tended to have greater decreases in pill counts for corticosteroids and 5-ASA, while males showed statistically significant reductions in pill count for immunosuppressants compared with females. Conclusions: This study demonstrates that the prescription of nonbiologic medications significantly decreased after biologic therapy initiation. The use of biologics may therefore lead to improved disease management and potentially better patient outcomes. Full article
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